A5100367263- interferon and immune responses
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- Nerve injury and regeneration
- Nicotinic Acetylcholine Receptors Study
- Immune Response and Inflammation
- Asthma and respiratory diseases
- Receptor Mechanisms and Signaling
- Immune responses and vaccinations
- Pharmacovigilance and Adverse Drug Reactions
- Nuclear Receptors and Signaling
- Allergic Rhinitis and Sensitization
- Computational Drug Discovery Methods
- Multiferroics and related materials
- Regional Development and Environment
- Cardiac Imaging and Diagnostics
- Medical and Biological Ozone Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Epilepsy research and treatment
- Peroxisome Proliferator-Activated Receptors
- Ocular Oncology and Treatments
- Ion channel regulation and function
- S100 Proteins and Annexins
Qingdao University
2013-2025
Qingdao Municipal Hospital
2018-2024
First Hospital of Shanxi Medical University
2023
Shanxi Medical University
2023
Harvard University
2015-2022
Harvard Pilgrim Health Care
2015-2022
The present study aimed to determine whether a polysaccharide obtained from Spirulina platensis shows protective effects on dopaminergic neurons. A Parkinson's disease model was established through the intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in C57BL/6J mice. Prior MPTP injection, some mice were pretreated with injections derived once daily for 10 days. results showed that immunoreactive staining and mRNA expression dopamine transporter tyrosine...
Chronic, heavy alcohol use may lead to permanent brain damage, cognitive impairment, and dementia. One of the most serious consequences is alcoholic dementia (AlD). Phosphodiesterase-4 (PDE4) inhibitors have been shown exhibit beneficial effects on cognition deficits alcoholism. However, it not known whether PDE4 can be used treat AlD. A33, a relatively selective PDE4B inhibitor, absent emetic effect associated with PDE4D. The A33 memory in AlD remains unclear. We investigated inhibitor...
A series of novel thiazolo[4,5-d]pyrimidin-7(6H)-ones (3aa–3eq) were designed, synthesized, and evaluated as the type I positive allosteric modulators human α7 nAChR expressed in Xenopus ooctyes by a two-electrode voltage clamp. The structure–activity relationship analysis identified compound 3ea potent efficacious PAM with maximum activation effect current over 1633% presence acetylcholine (100 μM) an EC50 = 1.26 μM. It is highly specific to other subtypes nAChR, 5-HT3A, NMDA, GABAA...
Accumulation of α‑synuclein (α‑SYN) is a common pathology for Parkinson's disease (PD). There abundant evidence that the toxic‑gain‑of‑function α‑SYN's associated with aggregation and consequent effects. To assess potential chondroitin sulfate (CS) in this regard, present study investigated its neuroprotective on SH‑SY5Y cells overexpressing wild‑type (WT) or A53T mutant α‑SYN. Cell viability was measured by MTT assay. Apoptosis, reactive oxygen species (ROS) mitochondrial membrane were...
Candida albicans meningitis is a fungal infectious disease of the central nervous system that most often occurs in immunodeficient populations. Kimura's an IgE-mediated inflammatory reactive chronic immune disorder with predominantly lymph node, soft tissue, and salivary gland damage, treatment which hormone-based. The combination C. relatively uncommon. Herein, we report case disease.The 26-year-old male medical history Kimura, who presented symptoms dizziness, headache, double vision....
Abstract Purpose Develop and test a flexible, scalable tool using interrupted time series (ITS) analysis to assess the impact of Food Drug Administration (FDA) regulatory actions on drug use. Methods We applied in Sentinel Distributed Database FDA's 2010 safety communications (DSC) concerning long‐acting beta2‐agonists (LABA) adult asthma patients. evaluated changes LABA use by measuring initiation alone concomitant controller medications (ACM) after DSCs. The generated ITS graphs used...
Magnetic measurements were performed on Yb3Fe5−xScxFe5O12(YbIG:Sc), x=0.5, single crystal platelets oriented along and perpendicular to the [111] crystallographic direction, in 1.5–20 K temperature range a magnetic field up 330 kOe. Along [110] [100] axis H was limited 230 kOe 4.2–300 range. When is parallel first-order induced transition are observed below about 10 K; variations of very different. applied monotonous behavior simply found. A noticeable anisotropy between properties three...