A5042403168- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects of Natural Compounds
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Biochemical Analysis and Sensing Techniques
- Endoplasmic Reticulum Stress and Disease
- Traditional Chinese Medicine Analysis
- Medicinal Plants and Neuroprotection
- Berberine and alkaloids research
- Parkinson's Disease Mechanisms and Treatments
- Glycosylation and Glycoproteins Research
- Sphingolipid Metabolism and Signaling
- Image Processing Techniques and Applications
- Textile materials and evaluations
- Industrial Vision Systems and Defect Detection
- Galectins and Cancer Biology
- GABA and Rice Research
- Colorectal Cancer Screening and Detection
- Drug-Induced Hepatotoxicity and Protection
- Cannabis and Cannabinoid Research
- Herbal Medicine Research Studies
- Plant-based Medicinal Research
- Synthesis of Organic Compounds
- Toxin Mechanisms and Immunotoxins
Nanjing University of Chinese Medicine
2020-2025
China Textile Academy
2021
China Pharmaceutical University
2018-2019
Guangdong Pharmaceutical University
2016
Background Colorectal cancer (CRC) is one of the most common malignant gastrointestinal cancers in world with a 5-year survival rate approximately 68%. Although researchers accumulated many scientific studies, its pathogenesis remains unclear yet. Detecting and removing these polyps promptly effective method CRC prevention. Therefore, analysis disposal conducive to preventing CRC. Methods In study, metabolic profiling as well diagnostic biomarkers for was investigated using untargeted...
Neu1 is a sialidase enzyme that plays crucial role in the regulation of glycosylation variety cellular processes, including signaling and inflammation. In recent years, numerous evidence has suggested human NEU1 also involved pathogenesis various respiratory diseases, lung infection, chronic obstructive pulmonary disease (COPD), asthma, fibrosis. This review paper aims to provide an overview current research on diseases.
Parkinson's disease (PD) is a multifactorial degenerative of the central nervous system, which affects mostly older adults. To date, research has focused on progression PD. Simultaneously, it was confirmed that imbalances in gut microbiota are associated with onset and Accurate diagnosis precise treatment PD currently deficient due to absence effective biomarkers.In this study, pharmacodynamic study cyanidin-3-O-glucoside mice used. It intends use "imbalance" "balance" intestinal...
Parkinson’s disease (PD) could be viewed as a proteinopathy caused by changes in lipids, whereby modifications lipid metabolism may lead to protein alterations, such the accumulation of alpha-synuclein (α-syn), ultimately resulting neurodegeneration. Although loss dopaminergic neurons substantia nigra is major clinical manifestation PD, etiology it largely unknown. Increasing evidence has highlighted important role lipids pathophysiology PD. Sphingosine-1-phosphate (S1P), signaling lipid,...
Ulcerative colitis (UC) is the most frequent disease classified under umbrella term inflammatory bowel (IBD) with potentially serious symptoms and devastating consequences for affected patients.
Cholestasis is characterized by bile acid (BA) circulation disorders, which usually related to damage of hepatocyte barrier function. Currently, patients with cholestasis face several obstacles in seeking diagnosis and therapy. Da-Huang-Xiao-Shi decoction (DHXSD) an ancient classic formula that has been used clinically for treatment. Nevertheless, the underlying biological activities therapeutic mechanisms remain unclear. In this study, alpha-naphthylisothiocyanate (ANIT)-induced rat model...
Parkinson's disease (PD), the typical neurodegenerative disease, is characterized by progressive loss of dopaminergic neurons in substantia nigra (SN). However, no therapeutic agent used currently could slow down neuronal cell so as to decelerate or halt progression PD. Traditional Chinese medicine (TCM) has been utilized treat dysfunction autonomic nervous system. Wen-Shen-Yang-Gan decoction (WSYGD) a good effect on clinical treatment PD with constipation. it not clear which ingredients and...
This study aimed to explore the protective effects of Wenshen-Yanggan decoction on dopaminergic (DA) neuron injury in a rotenone‐induced mouse model with chronic Parkinson’s disease (PD) and its mechanism action. Ultraperformance liquid chromatography‐tandem mass spectrometry (UPLC‐MS/MS) was used measure content six main components decoction. The PD established by treating 10‐month‐old healthy wild C57BL/6 male mice rotenone 30 mg/kg/day for 28 days succession. pole test rotarod were...
Cortex Phellodendri is derived from two species of Phellodendron amurense Rupr. and chinense Schneid. Traditionally, the are utilized interchangeably under name "huangbo" in clinic because they believed to share same clinical efficacy. However, chemical analysis vitro couldn't directly reflect pharmacological effects. Therefore, whether constituents could be absorbed into blood becomes uppermost problem account for efficacy differences species. a rapid sensitive approach differentiate based...
Plasma metabolic profiling of normal and ANIT-induced cholestasis rats after oral administration DHXSD was analysis by UHPLC-Q-Orbitrap MS.
Introduction: Phellodendri Chinensis Cortex is a necessary part of healthcare for its significant clinical efficacy. Raw and processed both documented in the Chinese Pharmacopoeia (2015). After processing, therapeutic effects are believed to differ according traditional medicine theories. However, chemical mechanism responsible this theories, still not clear. Methods: In study, various ions were examined based on theories by ultra-high performance liquid chromatography-hybrid...
Background: The multi-factorial degenerative disease of Parkinson’s (PD) is the central nervous system disease, which affects mostly older adults. Simultaneously, previous study revealed that imbalances gut microbiota could produce an effect on progression PD. accurate diagnoses and precise treatment PD are currently deficient as a result absent effective biomarkers.Methods: In this study, pharmacodynamic Cyanidin-3-O-glucoside in mice was applied. Metabolomics analysis implemented to...
Background: Cholestasis is characterized by bile acid (BA) circulation disorders, which usually related with the damage of hepatocyte barrier function. At present, patients cholestasis confronts a number obstacles in seeking diagnosis and therapy. Da-Huang-Xiao-Shi Decoction (DHXSD) an ancient classic formula has been utilized for treatment clinic. Nevertheless, it underlying biological activity therapeutic mechanism remain unclear.Methods: This study aimed to evaluate anti-cholestatic...
Abstrcat: Fabric image retrieval is of great value to the management fabric information in textile factories, but diversity images makes it difficult extract features during retrieval. This paper proposes a feature extraction algorithm based on InceptionV3 transfer learning, which uses pre-trained neural network perform learning and fine-tune build database. The experiment was carried out data set FID (Fabric Image Dataset). Experiments show that can ameliorate accuracy extraction, with...