A5101772485- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Genetic Mapping and Diversity in Plants and Animals
- Hepatitis B Virus Studies
- GABA and Rice Research
- Molecular Biology Techniques and Applications
- Angiogenesis and VEGF in Cancer
- Sirtuins and Resveratrol in Medicine
- Lipid metabolism and disorders
- Atrial Fibrillation Management and Outcomes
- Lipid metabolism and biosynthesis
- Diet, Metabolism, and Disease
- Coronary Interventions and Diagnostics
- Liver Disease and Transplantation
- Kruppel-like factors research
- Cardiovascular Syncope and Autonomic Disorders
- Drug-Induced Hepatotoxicity and Protection
- Photosynthetic Processes and Mechanisms
- Chronic Lymphocytic Leukemia Research
- Cardiovascular Function and Risk Factors
- Takotsubo Cardiomyopathy and Associated Phenomena
- Apelin-related biomedical research
- Soybean genetics and cultivation
- Genetics and Plant Breeding
- Autophagy in Disease and Therapy
Peking University Third Hospital
2006-2024
Peking University
2006-2024
Harbin Medical University
2007-2023
First Affiliated Hospital of Harbin Medical University
2023
Ministry of Education of the People's Republic of China
2013-2020
Jiangsu Academy of Agricultural Sciences
2018-2020
Ministry of Agriculture and Rural Affairs
2020
Second Affiliated Hospital of Harbin Medical University
2007-2018
Nanjing Agricultural University
2018
Abstract Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genotyping 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify additional loci influencing lipid levels. Single-variant analysis on 65,671 single nucleotide polymorphisms reveals 19 associated with at significance ( P <2.69 × 10 −7 ), including three Asian-specific coding variants in known genes CETP p.Asp459Gly, PCSK9 p.Arg93Cys and...
The therapeutic effect of pegylated interferon (peg-IFN)-alpha-2a combination with ribavirin on patients chronic hepatitis C virus (HCV) infection is dependent the rapidity virological response. aim this study was to investigate predictive value rapid response (RVR) and early (EVR) sustained (SVR) in HCV treated peg-IFN-alpha-2a ribavirin.The genotypes 105 were detected by enzyme-immunoassay. Patients received subcutaneous 180 microg once weekly plus daily ribavirin. genotype 1 for 48 weeks...
Chronic hepatitis B virus (HBV) infection is a major global health issue, and the prognosis of patients with HBV-associated acute-on-chronic hepatic failure (ACLF) extremely poor. In this study, efficacy lamivudine was investigated in ACLF. The effects HBV DNA load its related factors on were also further explored.A matched retrospective cohort study using data ACLF derived from our hospital database conducted. One hundred thirty receiving selected into treatment group another 130 without...
Steatosis and insulin resistance induced by hepatitis C virus (HCV) infection are, at least in part, critical factors for the progression of chronic (CHC) can influence outcome antiviral treatment. Silent information regulator 1 (SIRT1) adenosine monophosphate-activated protein kinase (AMPK) play a key role regulation hepatic glucose lipid metabolism. The aim this study was to investigate possible effect HCV core on energy, glucose, metabolism hepatocytes expression SIRT1 AMPK.HCV plasmid...
The fatty acid composition of B. napus' seeds determines the oil's nutritional and industrial values, affects seed germination. Many studies have reported correlations among C16:0, C18:0, C18:1, C18:2 C18:3 based on phenotypic data; however, genetic basis in napus is still not well understood. In this study, unconditional conditional quantitative trail locus (QTL) mapping analyses were conducted using a recombinant inbred line six environments. total, 21 consensus QTLs each for C18:0 C18:2,...
We used the model for end-stage liver disease (MELD) scoring system to predict 3-month prognosis of patients with acute-on-chronic failure (ACLF) after plasma exchange (PE) and lamivudine treatment, studied predictive factors on patients.A total 280 treated were randomly divided into PE control groups. The relationship between mortality influential was by univariate multivariate analysis.The (49.4%) in group a MELD score from 30 40 lower than that (86.1%) (chi(2) = 24.546, P < 0.01)....
Insulin resistance (IR) affects sustained virological response (SVR) in chronic hepatitis C (CHC). The aim of this study was to investigate the effect adding metformin peginterferon alfa-2a and ribavirin on efficacy patients with genotype 1 CHC IR.Ninety-eight IR were randomized into treatment group (n=49) control (n=49). Patients received ribavirin, addition ribavirin. rate response, changes homeostasis model assessment insulin (HOMA-IR) index, incidence side effects compared between two...
Insulin resistance is highly prevalent in patients with chronic hepatitis C (CHC) and to some extent accounts for fibrosis reducing viral eradication. Activated cannabinoid 1 receptor (CB1R) signaling has been implicated the development of phenotypes associated insulin steatosis. We investigated role endocannabinoid system glucose metabolism disorders induced by virus (HCV) replication.Human hepatic stellate cells (HSC; LX-2 cells) were co-cultured Huh-7.5 or harboring HCV replicon (replicon...
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease featured by insulin resistance (IR) and decreased secretion. Currently, vitamin D deficiency found in most patients with T2DM, but the relationship between IR T2DM requires further investigation.To explore risk factors of effects supplementation on glucose lipid metabolism T2DM.Clinical data 162 treated First Affiliated Hospital Harbin Medical University January 2019 February 2022 were retrospectively analyzed. Based diagnostic...
Fulminant hepatitis B is a clinical syndrome that results from massive necrosis of liver cells leading to the development hepatic encephalopathy. The aim this study was evaluate efficacy lamivudine in patients with fulminant and prognostic factors.A matched retrospective cohort using data on derived our hospital database conducted. Forty receiving treatment were selected into group another 40 without studied as control. They for sex, age HBeAg status group. mortality two groups compared....
Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia characterized by atrial remodeling. Complement C1q tumor necrosis factor-related protein 3 (CTRP3) one of the adipokines associated with obesity, diabetes, and coronary heart disease. The association between plasma CTRP3 levels AF uncertain. aim this study was to investigate whether concentrations were correlated AF. Our included 75 patients who underwent catheter ablation at our hospital 47 sinus rhythm determine difference...
The aim of the present study was to investigate association serum angiopoietin (Ang)-1 and Ang-2 levels Ang-1 ratio (Ang-2/Ang-1) with heart failure (HF) in patients acute myocardial infarction (AMI) during hospitalization. AMI were measured at admission hospital. correlations between Ang-1, Ang-2/Ang-1 HF examined. Among 103 patients, 20 developed level found be significantly higher than without (2,203.1±122.0 vs. 2,102.3±114.4 pg/ml, P=0.001 11.4±1.6×10(-2) 10.6±1.1×10(-2), P=0.007,...
The relationship between patient sex and the effectiveness of peginterferon alpha-2a ribavirin treatment in chronic hepatitis C (CHC) patients remains unclear. aim this study was to investigate impact on virologic responses rates genotype 1 CHC patients.A matched retrospective cohort 630 treated with derived from our hospital database conducted. These were divided into three groups according age: aged <40 years (n=200), 40-50 (n=210), 51-60 (n=220). rate receiving ≥ 80% planned drug dose...
Hepatic fibrosis is a frequent feature of chronic hepatitis C virus (HCV) infection. Some evidence has suggested the potential role silent information regulator 1 (SIRT1) in organ fibrosis. The aim this study was to investigate effect HCV core protein on expression SIRT1 liver sinusoidal endothelial cell (LSEC) and function LSEC. LSECs were co‐cultured with HepG2 cells or expressing cultured alone used as controls. After co‐culture, activity levels mRNA LSEC detected by fluorometric assay...
Abstract Objective: To study the virological features of patients coinfected with hepatitis B virus (HBV) and C (HCV) efficacy combination therapy peginterferon α‐2a ribavirin in these patients. Methods: The epidemiological data 50 HBV HCV were analysed. response rates treated between coinfection group monoinfection compared. Results: HCV‐dominant strains accounted for 92.0% individuals, HCV‐ HBV‐dominant remaining 8.0%. DNA level was 4.6±0.9 log 10 copies/ml, which significantly lower than...
Hepatic steatosis is an important histopathological feature of chronic hepatitis C virus (HCV) infection. Silent information regulator 1 (SIRT1) plays key role in regulation hepatic lipid metabolism. We investigated the possible effect HCV replication on metabolism hepatocytes and expression SIRT1 using Huh-7.5 cells harboring replicon.The level reactive oxygen species (ROS) malondialdehyde (MDA), activity superoxide dismutase (SOD), value nicotinamide adenine dinucleotide (NAD(+) )/NADH was...
Context: Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) play divergent roles in myocardial ischemia reperfusion injury.Objective: To investigate serum Ang-1 Ang-2 levels ST-segment elevation infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI).Methods: Serum were measured 85 STEMI the first week after PCI.Results: Ang-1, Ang-2/Ang-1 ratio (Ang-2/1) all increased at admission, had dynamic changes PCI. Ang-2/1 admission 2 h PCI positively correlated peak...