A5091724295- Plant Molecular Biology Research
- Light effects on plants
- Photosynthetic Processes and Mechanisms
- Plant responses to water stress
- Cancer Immunotherapy and Biomarkers
- Plant Virus Research Studies
- GABA and Rice Research
- Lipid metabolism and biosynthesis
- CAR-T cell therapy research
- Plant Gene Expression Analysis
- Cytomegalovirus and herpesvirus research
- Molecular Biology Techniques and Applications
- Immune cells in cancer
- Plant Reproductive Biology
- Soybean genetics and cultivation
- Aquaculture Nutrition and Growth
- Atherosclerosis and Cardiovascular Diseases
- Plant Disease Resistance and Genetics
New England Biolabs (United States)
2023-2025
University of Geneva
2018-2023
University of Cologne
2012-2021
Cluster of Excellence on Plant Sciences
2015-2021
Ministry of Agriculture and Rural Affairs
2020
Jiangsu Academy of Agricultural Sciences
2020
Chinese Academy of Fishery Sciences
2013
Swedish University of Agricultural Sciences
2012
The Arabidopsis COP1/SPA E3 ubiquitin ligase is a key negative regulator that represses light signaling in darkness by targeting transcription factors involved the response for degradation. complex consists of COP1 and members four-member SPA protein family (SPA1-SPA4). Genetic analysis indicated COP1/SPA2 function particularly strongly repressed when compared to complexes carrying other three SPAs, thereby promoting after exposure plants extremely low light. Here, we show SPA2 degraded...
Plants have evolved complex photoreceptor-controlled mechanisms to sense and respond seasonal changes in day length. This ability allows plants optimally time the transition from vegetative growth flowering. UV-B is an important part intrinsic sunlight; however, whether how it affects photoperiodic flowering has remained elusive. Here, we report that, presence of UV-B, genetic mutation REPRESSOR OF PHOTOMORPHOGENESIS 2 ( RUP2 ) renders facultative long plant Arabidopsis thaliana a...
Abstract Non-invasive liquid biopsies are helping advance various aspects of disease assessment including early detection, monitoring, and therapy selection, while also allowing for improved patient follow-up economic efficiency over traditional tissue biopsies. Plasma cell-free DNA (cfDNA) applications have recently been adopted in prenatal screening, tumor mutation profiling post-transplant monitoring. Additionally, combining cfDNA with paired RNA analysis peripheral blood mononuclear...
Abstract The interplay between variations in transcriptome profiles and disease progression is an important area of study emerging cancer diagnostics. Whole-genome or targeted sequencing are conventional methods for somatic tumor assessment, but RNA has emerged as a powerful tool that can provide additional information on translation events tumorigenesis. Transcriptome dynamics reflect cell state reveal key features the evolution disease. (RNA-seq) transformed research by providing more...
Plants have evolved complex mechanisms to adapt growth and development the light environment. The COP1/SPA is a key repressor of photomorphogenesis in dark-grown Arabidopsis plants acts as an E3 ubiquitin ligase ubiquitinate transcription factors involved response. In light, activity inhibited by photoreceptors, thereby allowing accumulation these subsequent Previous results shown that four members SPA family exhibit partially divergent functions. particular, SPA1 SPA2 strongly differ their...
Arabidopsis (Arabidopsis thaliana) CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1) and members of the SUPPRESSOR OF PHYTOCHROMEA-105 (SPA) protein family form an E3 ubiquitin ligase that suppresses light signaling in darkness by polyubiquitinating positive regulators response. COP1/SPA is inactivated to allow photomorphogenesis proceed. Mechanisms inactivation include light-induced degradation SPA1 and, particular, SPA2, corresponding a particularly efficient COP1/SPA2 light. Here, we show SPA3 SPA4...
Abstract The adaptive immune system defends the human body from pathogens through recognition ability of antigen receptors B and T cells. Different organs play various function roles, therefore present varied cell gene expression repertoire profiles. Abnormality these profiles may reflect immunological disorder, presence neoplastic tissue, or response to infectious agent. High-throughput sequencing technology has facilitated understanding related functions, but in-depth phenotype clonotype...
Abstract The adaptive immune system defends the human body from pathogens through B/T cell functions in various organs. Abnormality of these cells may reflect immunological disorder, presence neoplastic tissue, or response to infectious agents. High-throughput sequencing technology has facilitated understanding gene expression and related functions. Still, an in-depth B T phenotype clonotype profiling is emerging application that yet take full advantage for disease diagnosis prognosis. Here,...
Abstract Photoperiodic plants coordinate the timing of flowering with seasonal light cues, thereby optimizing their sexual reproductive success. The WD40-repeat protein REPRESSOR OF UV-B PHOTOMORPHOGENESIS 2 (RUP2) functions as a potent repressor UV RESISTANCE LOCUS 8 (UVR8) photoreceptor-mediated induction under noninductive, short-day conditions in Arabidopsis (Arabidopsis thaliana); however, contrast, closely related RUP1 seems to play no major role. Here, analysis chimeric ProRUP1:RUP2...
Abstract The study of complex immunological diseases and tumor microenvironments has advanced through recent developments in sequencing the immune repertoire. Using this approach, interrogation disease progression is facilitated analysis millions V(D)J combinations from B cell receptors (BCRs) T (TCRs). One major challenge repertoire to accurately capture structural sequence complexities antibodies TCR genes during both library preparation bioinformatic analysis. In addition, lack standard...