A5103217295- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Venous Thromboembolism Diagnosis and Management
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Higher Education and Teaching Methods
- Schizophrenia research and treatment
- Education and Work Dynamics
- Cardiac electrophysiology and arrhythmias
- Acute Ischemic Stroke Management
- Tryptophan and brain disorders
- Cardiac Structural Anomalies and Repair
- Acute Myocardial Infarction Research
- Pulmonary Hypertension Research and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Evaluation Methods in Various Fields
- Cardiovascular Issues in Pregnancy
- COVID-19 and healthcare impacts
- Coronary Interventions and Diagnostics
- Cardiac Arrest and Resuscitation
- Health Systems, Economic Evaluations, Quality of Life
- Educational Technology and Pedagogy
- Lipoproteins and Cardiovascular Health
- Neuroscience and Neuropharmacology Research
Guangzhou Medical University
2025
Henan Psychiatric Hospital
2019-2025
Xinxiang Medical University
2019-2025
Laboratoire Lorrain de Recherche en Informatique et ses Applications
2023
Wuhan University
2008-2023
Wuhan Asia Heart Hospital
2008-2023
Wuhan General Hospital of Guangzhou
2023
The First Affiliated Hospital, Sun Yat-sen University
2022
Zhongshan Hospital
2022
Fudan University
2022
Abstract Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genotyping 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify additional loci influencing lipid levels. Single-variant analysis on 65,671 single nucleotide polymorphisms reveals 19 associated with at significance ( P <2.69 × 10 −7 ), including three Asian-specific coding variants in known genes CETP p.Asp459Gly, PCSK9 p.Arg93Cys and...
Abstract Background Evidence from functional and structural research suggests that abnormal brain activity plays an important role in the pathophysiology of schizophrenia (SZ). However, limited studies have focused on post-treatment changes, current conclusions are inconsistent. Study Design We recruited 104 SZ patients to resting-state magnetic resonance imaging scans at baseline 8 weeks treatment with second-generation antipsychotics, along scanning 86 healthy controls (HCs) for comparison...
Abstract Background: The National Chest Pain Centers Program (NCPCP) is the largest nationwide, hospital-based, multifaceted, continuous quality improvement initiative, which aims to monitor and improve of care for patients with acute chest pain. accreditation standardized pain center central project. purpose establishing centers develop a mechanism “sending hospital capabilities best treatment in shortest time possible.” Objectives: This study evaluate effectiveness implementation identify...
Abstract Background To establish a prediction model for cardiovascular diseases (CVD) in the general population based on random forests. Methods A retrospective study involving 498 subjects was conducted Xi'an Medical University between 2011 and 2018. The forest algorithm used to screen out variables that greatly affected CVD model. important were included multifactorial logistic regression analysis. area under curve (AUC) compared Results revealed variables, including age, body mass index...
The objectives of this research were 1) to study the current situation and supporting factors that enhance sustainable development Chinese dance teacher leadership in Shandong Province, 2) develop strategies for 3) Evaluate feasibility Province. sample group consisted 331 teachers questionnaires 12 experts interview who worked Dance Province sampled through random clusters. instruments included questionnaires, interviews, evaluation forms. data analysis statistics percentages, mean, standard...
Abstract Background Recent studies have increasingly utilized gradient metrics to investigate the spatial transitions of brain organization, enabling conversion macroscale features into low-dimensional manifold representations. However, it remains unclear whether alterations exist in cortical morphometric similarity (MS) network patients with schizophrenia (SCZ). This study aims examine potential differences principal MS between individuals SCZ and healthy controls explore how these relate...
Neuroimaging studies have identified a large number of biomarkers associated with schizophrenia (SZ), but there is still lack that can predict the efficacy antipsychotic medication in SZ patients. The aim this study was to identify neuroimaging drug response among features resting-state connectome. Resting-state functional magnetic resonance scans were acquired from discovery cohort 105 patients at baseline and after 8 weeks treatment. Baseline clinical status post-treatment outcome assessed...
Abstract The indoleamine 2,3-dioxygenase (IDO) enzyme is the first rate-limiting of tryptophan degradation pathway in which dysfunction neuroactive metabolites has been implicated pathophysiology schizophrenia. Inflammatory molecules such as pro-inflammatory cytokines could enhance activity IDO. There are few studies on expression IDO levels and its correlation with inflammatory first-episode drug-naive patients One hundred inpatients (female = 33, male 67) schizophrenia entered a 6-week,...
Prenatal exposure to polyriboinosinic-polyribocytidylic acid (poly I:C) results in psychotic-like behavior mature rat offspring as well enduring modifications of glutamatergic excitatory synaptic transmission. However, little is known about the dynamic behavioral and glutamate N-methyl-D-aspartate (NMDA) receptor changes following poly I:C treatment pregnant dams. In this study, was administered rats intravenously at a dose 10 mg/kg on gestational day 9 order assess NMDA receptors over time....
Abstract Background Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies with poor prognosis. There no research about clinical significance serum soluble CD155 (sCD155) level for HCC. We aim to explore prognostic and diagnostic value sCD155 in HCC patients undergoing curative resection. Methods Serum was determined by enzyme‐linked immunosorbent assay. The evaluated Cox regression Kaplan–Meier analyses. expression biomarkers immune cells tissues were detected...
Previous Caucasian studies have described venous thromboembolism in pregnancy; however, little is known about its incidence during pregnancy and early postpartum period the Chinese population. We investigated risk of a "real-world" cohort pregnant women with no prior history thromboembolism.In this observational study, 15,325 pregnancies were identified 14,162 at Queen Mary Hospital, Hong Kong between January 2004 September 2016. Demographic data, obstetric information, laboratory imaging...
The SARS-CoV-2 epidemic starting in Wuhan December, 2019 has spread rapidly throughout the nation. control measures to contain also produced influences on transport and treatment process of patients with acute myocardial infarction (AMI), adjustments management need be made at this particular time. AMI is characterized by an onset potentially fatal consequence, a short optimal window, frequent complications including respiratory infections circulatory failure, for which active on-site...
Functional deficits in schizophrenia (SZ) are observed prior to the onset of psychosis and differ at different stages SZ. However, there is a paucity studies focused on adolescent first-episode SZ (AOS), adult (AFES), chronic (CHSZ). In this study, we investigated regional activity corresponding functional connectivity alterations that have aimed compare three disease simultaneously. The subjects comprised 49 patients with AOS, 57 AFES, 51 CHSZ, 41 healthy controls, 138 controls. We compared...
The level of CHB virus (HBV) core antibody (HBcAb) is different in four stages chronic HBV infection and may be used for differential diagnosis the natural history infection. To address this question, we examined multiple blood biomarkers assessed efficacy to diagnose quantitative detection HBcAb, hepatitis B surface antigen (HBsAg), DNA, alanine aminotransferase (ALT), aspartate (AST), platelet count (PLT) were determined serum 73 cases low-replicative phase (LR), 46 immune-tolerant (IT),...
Abstract This study aims to investigate the dosage pattern, efficacy, and safety of sacubitril/valsartan (Sac/Val) in Chinese heart failure with reduced ejection fraction (HFrEF) patients regarding real-world settings. Patients from 27 centers a confirmed diagnosis HFrEF initiated Sac/Val treatment were enrolled. The primary objective was evaluate pattern change status. In final cohort 983 patients, outpatient demonstrated similar beneficial effect NT-proBNP cardiac function. After...
Abstract Background Spontaneous coronary artery dissection (SCAD) has emerged as an increasingly diagnosed cause of ST-segment elevation myocardial infarction (STEMI), which is easily missed or delayed. The effective use angiography (CAG) and advanced intracoronary imaging examinations in STEMI patients led to increased detection SCAD. Case presentation A 59-year-old woman with acute angina pectoris was detected by electrocardiography combined measurement enzymes. Due the ongoing pandemic...
Oxidative stress and neuroinflammation contribute to schizophrenia (SCZ) pathology may influence treatment efficacy. Matrix metalloproteinase 9 (MMP9) is a critical molecular node mediating the interaction between oxidative inflammation, so Here we examined associations of plasma MMP9 concentration with antipsychotic drug responses, clinical symptoms, brain structure. A total 129 healthy controls 124 patients SCZ were included in this study. Patients monitored clinically during 8 weeks...
<title>Abstract</title> Neuroimaging studies have identified a large number of biomarkers associated with schizophrenia (SZ), but there is still lack that can predict the efficacy antipsychotic medication in SZ patients. The aim this study was to identify neuroimaging drug response among features resting-state connectome. Resting-state functional magnetic resonance scans were acquired from discovery cohort 105 patients at baseline and after 8 weeks treatment. Baseline clinical status...
Abstract Mathematical application plays an irreplaceable role in various scientific fields, especially engineering technology and economic management. Mathematics is the basic subject of nine-year compulsory education, which occupies a large proportion on quality education China. learning undoubtedly very important for college students. If university mathematics teaching integrates mathematical modeling thought, student will be more convenient to study abstruse question. This method can...