A5032952390- Cancer-related molecular mechanisms research
- Apelin-related biomedical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Adipose Tissue and Metabolism
- GDF15 and Related Biomarkers
- Plant-Microbe Interactions and Immunity
- Reproductive System and Pregnancy
- Diabetes Management and Research
- Diet and metabolism studies
- Electromagnetic Launch and Propulsion Technology
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Urologic and reproductive health conditions
- Plant Pathogens and Fungal Diseases
- Plant Pathogens and Resistance
- Ovarian cancer diagnosis and treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Estrogen and related hormone effects
- Single-cell and spatial transcriptomics
- Urological Disorders and Treatments
- Ovarian function and disorders
- Genital Health and Disease
- Cancer Genomics and Diagnostics
Fudan University
2021-2025
Zhongshan Hospital
2023-2025
State Key Laboratory of Genetic Engineering
2021-2024
Obstetrics and Gynecology Hospital of Fudan University
2022
Dalian Maritime University
2015
Jiangnan University
2014
Abstract Neurotensin (NTS) is a secretory peptide produced by lymphatic endothelial cells. Our previous study revealed that NTS suppressed the activity of brown adipose tissue via interactions with NTSR2. In current study, we found depletion Ntsr2 in white adipocytes upregulated food intake, while local treatment intake. mechanistic suppression NTS-NTSR2 signaling enhanced phosphorylation ceramide synthetase 2, increased abundance its products ceramides C20–C24, and downregulated production...
Activation of the innate immune system before invasion pathogens is a promising way to improve resistance plant against infection while reducing use agricultural chemicals. Although several elicitors were used induce potato microbial pathogen infection, role curdlan oligosaccharide (CurdO) has not been established. In current study, defense responses investigated at biochemical and proteomic levels elucidate elicitation effect CurdOs in foliar tissues (Solanum tuberosum L. cv. McCain G1)....
Significance Lineage analysis is an important assay for developmental biology, cancer etc. Traditional tools in this field are time consuming, technically challenging, and demand of preexisting knowledge. By integrating exogenous barcodes into cells, single-cell RNA-sequencing (scRNA-seq) can be used to conduct such tasks, but these assays required significant expertise both wet- dry-laboratory experiments. We developed a user-friendly algorithm cell-lineage inference solely based on...
Serous borderline ovarian tumour (SBOT) is the most common type of BOT. Fertility sparing surgery (FSS) an option for patients with SBOT, though it may increase risk recurrence. The clinical and molecular features its recurrence are important need to be investigated in detail.An internal cohort 319 SBOT was collected from Aug 1, 2009 July 31, 2019 Obstetrics Gynecology Hospital Fudan University China. An external 100 Nov 30, Shandong Provincial factors were identified by multivariate cox...
Vulvar lichen sclerosis (VLS) is a dermatologic disorder that affects women worldwide. Women with VLS have white, atrophic papules on the vulva. They suffer from life-long intense pruritus. Corticosteroids are first-line of treatments and most effective medicines for VLS. Although has been speculated as an autoimmune disease long time, its pathogenesis molecular mechanism largely unknown. We performed comprehensive multi-omics analysis paired samples patients well healthy donors. From...
ABSTRACT In comparison to mouse, the developmental process of human islets has not been properly elucidated. The advancement single cell RNA-seq technology enables us study properties alpha and beta cells at resolution. By using mitochondrial genome variants as endogenous lineage-tracing markers, we found that have different lineage features. This finding suggests specific endocrine progenitors for cells, which is from mouse islet cells. strategy was also applied a chemically-induced...
The diet-induced obesity (DIO) mouse model has been widely used for studies. effects of storage conditions on the composition nutrients in high-fat diets (HFDs) and their impact metabolic homeostasis have not systemically investigated. In current study, we tested HFDs stored under different found that mice fed a HFD fridge (HFDfri) gained less weight than those freezer (HFDfre). Further analysis revealed changes relative abundance medium-chain triglyceride (MCT) HFDfri, which much lower...
SUMMARY Neurotensin (NTS) is a secretory peptide produced by the lymphatic endothelial cells (LEC). Our previous study revealed that NTS suppressed activity of brown adipose tissue via interactions with NTSR2. In current study, we found depletion Ntsr2 in white adipocytes upregulated food intake, while local treatment intake. Mechanistic suppression NTS-NTSR2 signaling enhanced phosphorylation ceramide synthetase 2 (CerS2), increased abundance its products C20-C24 and downregulated...
Based on the 10,000 TEU container ship, paper makes a research characteristics of bow thruster.According to open-water propeller characteristic chart controllable pitch propeller, analyzes lateral thrust thruster combining with data real builds thruster's mathematical model and simulation based MATLAB/Simulink.The Simulation torque thruster, as well parameter propulsion motor is achieved, it proved correct, could be used provide theoretical support for improving maneuverability large ship at...