A5100743002- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Virology and Viral Diseases
- Respiratory viral infections research
- Functional Brain Connectivity Studies
- Streptococcal Infections and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Dementia and Cognitive Impairment Research
- Clostridium difficile and Clostridium perfringens research
- Viral Infections and Vectors
- Medical Research and Treatments
- Viral gastroenteritis research and epidemiology
- Neurological Disease Mechanisms and Treatments
- Neonatal and Maternal Infections
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Bioinformatics and Genomic Networks
- Nutritional Studies and Diet
- Gut microbiota and health
- Medical Imaging Techniques and Applications
- Inflammasome and immune disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Autophagy in Disease and Therapy
Beijing University of Chinese Medicine
2016-2024
Rush University Medical Center
2018-2024
Academy of Military Medical Sciences
2015-2024
Institute of Microbiology
2015-2024
University of Electronic Science and Technology of China
2023-2024
Illinois Institute of Technology
2013-2023
Rush University
2023
Beijing Normal University
2023
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2023
First Affiliated Hospital of Henan University
2022
Findings from observational studies suggest that dietary patterns may offer protective benefits against cognitive decline, but data clinical trials are limited. The Mediterranean–DASH Intervention for Neurodegenerative Delay, known as the MIND diet, is a hybrid of Mediterranean diet and DASH (Dietary Approaches to Stop Hypertension) with modifications include foods have been putatively associated decreased risk dementia. Download PDF Research Summary. We performed two-site, randomized,...
Muramidase-released protein (MRP) is as an important virulence marker of Streptococcus suis (S. suis) serotype 2. Our previous works have shown that MRP can bind human fibrinogen (hFg); however, the function this interaction in S. meningitis not known. In study, we found deletion mrp significantly impairs hFg-mediated adherence and traversal ability across cerebral microvascular endothelial cells (hCMEC/D3). Measurement permeability to Lucifer yellow vitro Evans blue extravasation vivo show...
Viral inclusion bodies (IBs), or replication factories, are unique structures generated by viral proteins together with some cellular as a platform for efficient replication, but little is known about the mechanism underlying IB formation and fusion. Our previous study demonstrated that interaction between nucleoprotein (N) phosphoprotein (P) of human parainfluenza virus type 3 (HPIV3), an enveloped great medical impact, can form IBs. In this study, we found small IBs fuse each other to...
Streptococcus suis serotype 2 (SS2) is an emerging human pathogen worldwide. A large outbreak occurred in the summer of 2005 China. Serum samples from this revealed that levels main proinflammatory cytokines were significantly higher patients with streptococcal toxic-shock-like syndrome (STSLS) than meningitis only. However, mechanism underlying cytokine storm STSLS caused by SS2 remained unclear. In study, we found suilysin (SLY) protein inflammatory stimulus and native SLY (nSLY)...
Blood platelets play important roles during pathological thrombocytopenia in streptococcal toxic shock syndrome (STSS). Streptococcus suis (S. suis) an emerging human pathogen, can cause STSS similarly to S. pyogenes. However, interactions with are poorly understood. Here, we found that suilysin (SLY), different from other bacterial cholesterol-dependent cytolysins (CDCs), was the sole stimulus induced platelet aggregation. Furthermore, inside-out activation of GPIIb/IIIa mediated...
Paramyxovirus particles, like other enveloped virus are formed by budding from membranes of infected cells, and matrix (M) proteins critical for this process. To identify the M protein important process, we have characterized human parainfluenza type 3 (HPIV3) protein. Our results showed that expression HPIV3 alone is sufficient to initiate release virus-like particles (VLPs). Electron microscopy analysis confirmed VLPs morphologically similar virions. We identified a leucine (L302) residue...
Cell cycle regulation is one of the hallmarks virus-mediated oncogenesis. Epstein-Barr virus (EBV)-induced lymphomas express a repertoire essential viral latent proteins that regulate expression cell cycle-related to dysregulate this process, thereby facilitating proliferation infected cells. We now demonstrate EBV protein 3C (EBNA3C) stabilizes cyclin D2 progression. More specifically, EBNA3C directly binds and they colocalize together in nuclear compartments. show regulates promoter...
Abstract Τhe accuracy of template‐based neuroimaging investigations depends on the template's image quality and representativeness individuals under study. Yet a thorough, quantitative investigation how available standardized study‐specific T1‐weighted templates perform in studies older adults has not been conducted. The purpose this work was to construct high‐quality template specifically designed for adult brain, systematically compare new several other terms quality, performance spatial...
Influenza B virus (IBV) is highly contagious, spreads rapidly, and causes seasonal epidemic respiratory disease in the human population, especially immunocompromised people young children. Clinical manifestations this high-risk population are often more severe than immunocompetent hosts sometimes atypical. Therefore, rapid, accurate detection of IBV important.An amplified luminescent proximity homogeneous assay linked immunosorbent (AlphaLISA) was developed for by optimizing ratio...
ABSTRACT The phosphoprotein (P) of vesicular stomatitis virus (VSV) plays essential roles in viral RNA synthesis. It associates with nascent nucleoprotein (N) to form N 0 -P (free RNAs), thereby preventing the from binding cellular RNAs and maintaining a genomic encapsidation-competent for transcription replication. contributions phosphorylation P replication have been studied intensively, but concrete mechanism action still remains unclear. In this study, using VSV minigenome system, we...
Hepatitis C virus (HCV) is the leading cause of liver fibrosis, cirrhosis and hepatocellular carcinoma. It believed that continuous cell apoptosis contributes to HCV pathogenesis. Recent studies have shown infection can sensitize host cells TNF-related apoptosis-inducing ligand (TRAIL) induced apoptosis, but mechanism by which regulates TRAIL pathway remains unclear.Using a sub-genomic replicon full length virus, JFH-1, we demonstrate TRAIL-induced up-regulating two receptors, death receptor...
Abstract Platelet activation and platelet–neutrophil interactions have been found to be involved in inflammation, organ failure soft-tissue necrosis bacterial infections. Streptococcus suis , an emerging human pathogen, can cause streptococcal toxic-shock syndrome (STSS) similarly pyogenes . Currently, S. –platelet are poorly understood. Here, we that suilysin (SLY), the cholesterol-dependent cytolysin (CDC), was sole stimulus of induced platelet-neutrophil complexes (PNC) formation....
The swine leukocyte antigens (SLAs) are the multigene families related to immune responses. Little is known about effect of DRA gene on diarrheal disease. This study reported genetic diversity in exons 1, 3 and 4 290 Chinese Yantai black pigs. No variation was identified exon 3. In three genotypes two alleles were identified, generated by single nucleotide polymorphisms (SNPs). 4, there eight five containing seven SNPs detected with four being novel SNPs. low polymorphism found consistent...
Objective To determine the extent to which regional brain volumes associated with slow gait speed can inform subsequent cognitive decline in older adults from Rush Memory and Aging Project. Approach We utilized deformation-based morphometry (DBM) a whole-brain exploratory approach identify assessed over short distance during an in-home assessment. created deformation scores summarize gait-associated regions entered into series of longitudinal mixed effects models predicted change cognition...
A significant number of individuals diagnosed with non-small cell lung cancer (NSCLC) have distant metastases, and the concept oligometastatic NSCLC has shown promise in achieving a cure. Stereotactic body radiation therapy (SBRT) is currently considered viable treatment option for limited tumor metastases. It also been demonstrated that third-generation tyrosine kinase inhibitors (TKIs) are effective extending survival patients epidermal growth factor receptor (
Human parainfluenza virus type 3 is one of the main causes lower respiratory illness in newborns and infants. The role matrix protein (M) viral budding extensively studied, but effect M on replication remains to be determined. Using an HPIV3 minigenome assay, we found that reduced mingenome-encoded reporter activity even though it had unspecific expression cellular genes. Furthermore, inhibition RNA synthesis was proven independent its virus-like particles (VLPs)’ release ability. A VLP’s...
High-quality T1-weighted (T1w) and diffusion tensor imaging (DTI) brain templates that are representative of the individuals under study enhance accuracy template-based neuroimaging investigations, when they also located in a common space facilitate optimal integration information on morphometry characteristics. However, such multimodal have not been constructed for older adults. The purpose this work was threefold: (A) to introduce an iterative method construction T1w DTI aims at maximizing...
Older Black adults experience a high burden of depressive symptoms and cerebrovascular disease but the specific neurobiological substrates underlying association between late-life brain integrity are understudied, particularly in within-group designs.
Rotavirus is the main pathogen causing acute viral gastroenteritis. Accurate and rapid diagnosis of rotavirus infection important to determine appropriate treatment, prevention unnecessary antibiotics use control spread. In this study, we established a rapid, accurate, sensitive amplified luminescent proximity homogeneous assay linked immunosorbent (AlphaLISA) for detecting evaluated its efficacy in human stool samples. Our results demonstrated that sensitivity AlphaLISA (5 −8 )...
Vulvar lichen sclerosis (VLS) is a dermatologic disorder that affects women worldwide. Women with VLS have white, atrophic papules on the vulva. They suffer from life-long intense pruritus. Corticosteroids are first-line of treatments and most effective medicines for VLS. Although has been speculated as an autoimmune disease long time, its pathogenesis molecular mechanism largely unknown. We performed comprehensive multi-omics analysis paired samples patients well healthy donors. From...