A5085671582- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Genetics and Neurodevelopmental Disorders
- Congenital heart defects research
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- Neurogenesis and neuroplasticity mechanisms
- Catalytic Cross-Coupling Reactions
- Catalytic Alkyne Reactions
- Regulation of Appetite and Obesity
- Catalytic C–H Functionalization Methods
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics and Chromatin Dynamics
- T-cell and B-cell Immunology
- Photoreceptor and optogenetics research
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Epigenetics and DNA Methylation
- Education in Rural Contexts
- Circadian rhythm and melatonin
- Carbohydrate Chemistry and Synthesis
- Adipokines, Inflammation, and Metabolic Diseases
- Genetics, Aging, and Longevity in Model Organisms
- Immune Response and Inflammation
- Signaling Pathways in Disease
The University of Texas Southwestern Medical Center
2012-2025
Southwestern Medical Center
2019-2025
University of Bristol
2016-2018
Three-coordinate bipyridyl complexes of gold, [(κ2-bipy)Au(η2-C2H4)][NTf2], are readily accessed by direct reaction 2,2′-bipyridine (bipy), or its derivatives, with the homoleptic gold ethylene complex [Au(C2H4)3][NTf2]. The cheap and available ligands facilitate oxidative addition aryl iodides to Au(I) center give [(κ2-bipy)Au(Ar)I][NTf2], which undergo first aryl-zinc transmetalation second C–C reductive elimination produce biaryl products. products each distinct step have been...
Under the conditions of oxidative gold catalysis, exposure ethylene to aryl silanes and alcohols generates products 1,2-oxyarylation. This provides a rare example process that allows catalytic differential 1,2-difunctionalization this feedstock chemical.
Mutations in the transcription factor Forkhead box p1 ( FOXP1 ) are causative for neurodevelopmental disorders such as autism. However, function of within brain remains largely uncharacterized. Here, we identify gene expression program regulated by FoxP1 both human neural cells and patient-relevant heterozygous Foxp1 mouse brains. We demonstrate a role transcriptional regulation autism-related pathways well genes involved neuronal activity. show that regulates excitability striatal medium...
Forkhead box protein P1 (FOXP1), a transcription factor enriched in the neocortex, is associated with autism spectrum disorders (ASDs) and FOXP1 syndrome. Emx1Cre/+;Foxp1fl/fl conditional deletion (Foxp1 knockout [cKO]) mouse cortex leads to overall reduced thickness, alterations cortical lamination, changes relative thickness of layers. However, developmental cell-type-specific mechanisms underlying these remained unclear. We find that Foxp1 results accelerated pseudo-age during early...
The striatum is a critical forebrain structure integrating cognitive, sensory, and motor information from diverse brain regions into meaningful behavioral output. However, the transcriptional mechanisms underlying striatal development at single-cell resolution remain unknown. Using RNA sequencing (RNA-seq), we examine cellular diversity of early postnatal show that Foxp1, transcription factor strongly linked to autism intellectual disability, regulates composition, neurochemical...
Long-range glutamatergic inputs originating from the cortex and thalamus are indispensable for striatal development, providing foundation motor cognitive functions. Despite their significance, transcriptional regulation governing these remains largely unknown. We investigated role of a transcription factor encoded by high-risk autism-associated gene, FOXP1 , in sculpting onto spiny projection neurons (SPNs) within striatum. find neuron subtype-specific strengthening maturing dopamine...
Genetic perturbations of the transcription factor Forkhead Box P1 (FOXP1) are causative for severe forms autism spectrum disorder that often comorbid with intellectual disability. Recent work has begun to reveal an important role FoxP1 in brain development, but brain-region-specific contributions Foxp1 and disability phenotypes have yet be determined fully. Here, we describe conditional knock-out (Foxp1cKO) male female mice loss pyramidal neurons neocortex CA1/CA2 subfields hippocampus....
The molecular mechanisms driving brain development at risk in autism spectrum disorders (ASDs) remain mostly unknown. Previous studies have implicated the transcription factor FOXP1 both and ASD pathophysiology. However, specific pathways upstream of downstream from are not fully understood. To elucidate contribution FOXP1-mediated signaling to and, particular, neocortical development, we generated forebrain-specific Foxp1 conditional knockout mice. We show that deletion developing forebrain...
The use of a bifunctional cinchona/thiourea organocatalyst for the direct and α-stereoselective glycosylation 2-nitrogalactals is demonstrated first time. conditions are mild, practical, applicable to wide range glycoside acceptors with products being isolated in good excellent yields. method exemplified synthesis mucin type Core 6 7 glycopeptides.
Obesity rates continue to rise throughout the world. Recent evidence has suggested that environmental factors contribute altered energy balance regulation. However, role of epigenetic modifications central control homeostasis remains unknown. To investigate DNA methylation in regulation balance, we investigated de novo methyltransferase, Dnmt3a, Single-minded 1 (Sim1) cells, including neurons paraventricular nucleus hypothalamus (PVH). Dnmt3a expression levels were decreased PVH high-fat-fed...
Genetic studies have associated FOXP2 variation with speech and language disorders other neurodevelopmental (NDDs) involving pathology of the cortex. In this brain region, FoxP2 is expressed from development into adulthood, but little known about its downstream molecular behavioral functions. Here, we characterized cortex-specific Foxp2 conditional knockout mice found a major deficit in reversal learning, form flexibility. contrast, they showed normal activity levels, anxiety, vocalizations,...
Abstract Identifying neuronal molecular markers with restricted patterns of expression is a crucial step in dissecting the numerous pathways and functions brain. While dorsomedial nucleus hypothalamus (DMH) has been implicated host physiological processes, current functional studies have limited by lack specific for DMH. Identification such would facilitate development mouse models DMH‐specific genetic manipulations. Here we used combination laser‐capture microdissection (LCM) gene profiling...
Cortical development is a tightly controlled process and any deviation during may increase the susceptibility to neurodevelopmental disorders, such as autism spectrum disorders (ASD). Numerous studies identified mutations in
Abstract Core circadian-related proteins such as the transcription factor CLOCK are ubiquitously expressed and important for regulating molecular pathways underlying circadian rhythms. Previous work has suggested that evolved human neocortex-specific gene regulation therefore may have extra-circadian functions. To test this in vivo, we generated a mouse model recapitulates cortical expression of CLOCK. The humanized (HU) mice show enhanced cognitive flexibility, which is associated with...
Abstract The striatum is a critical forebrain structure for integrating cognitive, sensory, and motor information from diverse brain regions into meaningful behavioral output. However, the transcriptional mechanisms that underlie striatal development organization at single-cell resolution remain unknown. Here, we show Foxp1, transcription factor strongly linked to autism intellectual disability, regulates organizational features of circuitry in cell-type-dependent fashion. Using...
Abstract Genetic studies have associated FOXP2 variation with speech and language disorders other neurodevelopmental involving pathology of the cortex. In this brain region, FoxP2 is expressed from development into adulthood, but little known about its downstream molecular behavioral functions. Here, we characterized cortex-specific Foxp2 conditional knockout mice found a major deficit in reversal learning, form flexibility. contrast, they showed normal activity levels, anxiety,...