A5029499864- Circadian rhythm and melatonin
- Behavioral Health and Interventions
- Neurobiology and Insect Physiology Research
- Sex and Gender in Healthcare
- Single-cell and spatial transcriptomics
- Gene expression and cancer classification
- Genetic Associations and Epidemiology
- Health, Environment, Cognitive Aging
- Cardiovascular Health and Risk Factors
- Dietary Effects on Health
- Gene Regulatory Network Analysis
- Insect and Arachnid Ecology and Behavior
- Neurogenesis and neuroplasticity mechanisms
- Immune Cell Function and Interaction
- scientometrics and bibliometrics research
- Biomedical Text Mining and Ontologies
- Academic Publishing and Open Access
- Genetics and Physical Performance
The University of Texas Southwestern Medical Center
2025
Southwestern Medical Center
2025
Vanderbilt University Medical Center
2022-2023
Forkhead box protein P1 (FOXP1), a transcription factor enriched in the neocortex, is associated with autism spectrum disorders (ASDs) and FOXP1 syndrome. Emx1Cre/+;Foxp1fl/fl conditional deletion (Foxp1 knockout [cKO]) mouse cortex leads to overall reduced thickness, alterations cortical lamination, changes relative thickness of layers. However, developmental cell-type-specific mechanisms underlying these remained unclear. We find that Foxp1 results accelerated pseudo-age during early...
Background: Drugs targeting triglyceride (TG)-associated genes have the potential to improve cardiovascular outcomes for patients with elevated TG levels. However, we know little regarding additional benefits or deleterious effects of such targeting, particularly among individuals African ancestry (AA). Mendelian randomization and PheWAS approaches offer opportunity examine primary secondary effects. Methods: We examined 12 variants reported previously in studies from 5 that been identified...
Genome-scale data have revealed daily rhythms in various species and tissues. However, current methods to assess rhythmicity largely restrict their focus quantifying statistical significance, which may not reflect biological relevance. To address this limitation, we developed a method called LimoRhyde2 (the successor our LimoRhyde), focuses instead on rhythm-related effect sizes uncertainty. For each genomic feature, fits curve using series of linear models based periodic splines, moderates...
Genome-scale data have revealed daily rhythms in various species and tissues. However, current methods to assess rhythmicity largely restrict their focus quantifying statistical significance, which may not reflect biological relevance. To address this limitation, we developed a method called LimoRhyde2 (the successor our LimoRhyde), focuses instead on rhythm-related effect sizes uncertainty. For each genomic feature, fits curve using series of linear models based periodic splines, moderates...
Biomedical research on mammals has traditionally neglected females, raising the concern that some scientific findings may generalize poorly to half population. Although this lack of sex inclusion been broadly documented, its extent within circadian genomics remains undescribed. To address gap, we examined practices in a comprehensive collection publicly available transcriptome studies daily rhythms. Among 148 having samples from vivo, found strong underrepresentation females across organisms...
Abstract Introduction: Insomnia is a significant co-morbidity for cancer survivors, and can independently reduce lifespan, but there currently no objective biochemical measure of insomnia. Circadian rhythms are 24 hour cycles that control physiologic processes including sleep. Disrupted circadian have been proposed as cause Here, we describe the use novel biomarker, BloodCCD, to assess from RNA-sequencing blood samples two independent clinical trials one observational study. BloodCCD was...
Abstract Biomedical research on mammals has traditionally neglected females, raising the concern that some scientific findings may generalize poorly to half population. Although this lack of sex inclusion been broadly documented, its extent within circadian genomics remains undescribed. To address gap, we examined practices in a comprehensive collection publicly available transcriptome studies daily rhythms. Among 148 having samples from vivo, found strong underrepresentation females across...