A5102884811- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Pancreatic function and diabetes
- Biotin and Related Studies
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Metabolism, Diabetes, and Cancer
- Neuroendocrine Tumor Research Advances
- Phytoestrogen effects and research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Diet, Metabolism, and Disease
- Electrochemical sensors and biosensors
- Diet and metabolism studies
- Protein Hydrolysis and Bioactive Peptides
- Biochemical effects in animals
- Adipose Tissue and Metabolism
- Lung Cancer Diagnosis and Treatment
- Estrogen and related hormone effects
- Cellular transport and secretion
- Amino Acid Enzymes and Metabolism
- NF-κB Signaling Pathways
- Alcoholism and Thiamine Deficiency
- Inflammatory mediators and NSAID effects
- Microbial Metabolites in Food Biotechnology
- Occupational exposure and asthma
University of Niigata Prefecture
2012-2024
Kitasato University
2018-2021
Nihon University
2021
Hyogo Medical University
2021
Niigata Institute of Technology
2019
Jichi Medical University
2006-2014
Tohoku University
1999-2012
The gastric hormone ghrelin and its receptor, growth secretagogue receptor (GHSR), are expressed in pancreas. Here, we report that is released from pancreatic islets to regulate glucose-induced insulin release. Plasma concentrations of ghrelin, as well insulin, were higher veins than arteries. GHSR antagonist immunoneutralization endogenous enhanced release perfused pancreas, whereas exogenous suppressed it. increased plasma levels gastrectomized normal rats a similar extent. Ghrelin...
Obesity rates continue to rise throughout the world. Recent evidence has suggested that environmental factors contribute altered energy balance regulation. However, role of epigenetic modifications central control homeostasis remains unknown. To investigate DNA methylation in regulation balance, we investigated de novo methyltransferase, Dnmt3a, Single-minded 1 (Sim1) cells, including neurons paraventricular nucleus hypothalamus (PVH). Dnmt3a expression levels were decreased PVH high-fat-fed...
We studied interactive effects of insulinotropic GLP‐1 and insulinostatic ghrelin on rat pancreatic islets. potentiated glucose‐induced insulin release cAMP production in isolated islets [Ca 2+ ] i increases single β‐cells, these potentiations were attenuated by ghrelin. Ghrelin suppressed responses to an adenylate cyclase activator forskolin. Moreover, GLP‐1‐induced markedly enhanced [ d ‐lys 3 ]‐GHRP‐6, a receptor antagonist, These results indicate that both exogenous endogenous...
The effect of biotin administration on the glucose tolerance streptozotocin (STZ)-induced diabetic Wistar rats was investigated. STZ-induced diabetes induced by intraperitoneal injection (45 mg/kg body weight as a single dose). impaired in response to an oral load (1.8g per kg weight) (STZ-rat) partially improved for 15 days (100 micrograms/rat/day). However, recovery STZ-rat's insulin secretion not found after administration. To help clarify mechanism underlying improvement seen with...
Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for type 2 diabetes mellitus. In the present study, we investigated whether pharmacologic doses of biotin have potential to abate insulin resistance in skeletal muscles OLETF rats. rats (34 weeks age) were divided into groups and given distilled water (OLETF-control group) or containing 3.3 mg L−1 (OLETF-biotin 8 weeks. At end experimental period, OLETF-control developed severe hyperglycemia hyperinsulinemia, whereas...
Vitamin K2 is indispensable for blood coagulation and bone metabolism. Menaquinone-4 (MK-4) the predominant homolog of vitamin K2, which present in large amounts pancreas, although its function unclear. Meanwhile, β-cell dysfunction following insulin secretion has been found to decrease patients with type 2 diabetes mellitus. To elucidate physiological MK-4 pancreatic β-cells, we studied effects treatment on isolated mouse islets rat INS-1 cells. Glucose-stimulated significantly increased...
Danazol and gonadotropin-releasing hormone agonists which are used as therapeutic drugs for endometriosis, develop adverse reactions in association with their long-term use. The efficacy of anti-estrogens an estrogen-dependent disorder, has not been demonstrated. A novel, orally active anti-estrogen, TZE-5323 ((2-cyclohexy-6-hydroxybenzo[b]thien-3-yl)[4-[2-(1- piperidinyl)ethoxy]phenyl] methanone hydrochloride, CAS 150797-71-0; free salt formula) was developed. showed strong affinity human...
Perifused isolated rat islets were used to show that biotin plus 16.5 mM glucose evoked more insulin secretion than alone. Whether or not this reinforcement of glucose-induced by is unique was studied using perifused stimulated with 100 μM one various components the vitamin B group. No effect any these vitamins found on secretion. These results indicate among members group in enhancing Static incubation experiments showed did potentiate release when incubated an experimental solution...
Background Carboplatin plus etoposide (CE) is a standard treatment for elderly patients with extensive‐disease small cell lung cancer (ED‐SCLC). However, amrubicin monotherapy (AMR) may be feasible alternative. We compared the efficacies and safety profiles of CE AMR ED‐SCLC in chemotherapy‐naive poor performance status (PS). Methods The records SCLC who received or as first‐line chemotherapy were retrospectively reviewed their outcomes evaluated. Results Eighty‐four (median age 72 years; 42...
Background: The optimal chemotherapy regimen for non-small-cell lung cancer (NSCLC) patients with interstitial disease (ILD) remains unknown. Therefore, in this study, we investigated the real-world efficacy and safety of carboplatin (CBDCA) plus nab-paclitaxel (nab-PTX) as a first-line NSCLC ILD. Patients methods: We retrospectively reviewed advanced ILD who had received CBDCA nab-PTX between April 2013 March 2018. were diagnosed based on findings pretreatment high-resolution computed...
Gastrectomy reduces food intake and body weight (BW) hampering recovery of physical conditions. It also plasma levels stomach-derived orexigenic ghrelin. This study explored changes in ghrelin system rats receiving total gastrectomy with Billroth II (B-II) or Roux-en-Y (R-Y) method. Feeding BW were reduced by subsequently recovered to a greater extent R-Y than B-II while decreased similarly. At postoperative 12th week, contents increased the duodenum pancreas, upon fasting, injection...
Supplementation with cartilage constituents, such as glucosamine, chondroitin sulfate and collagen peptide, are believed to reduce pain associated joint disorders, rheumatoid arthritis (RA). Here, we administered daily, 10 mg glucosamine or 100 chicken hydrolysate (CH) SKG/Jcl mice, a model for spontaneous RA, 5 weeks evaluated their effects on RA development. In SKG the administration of had no reducing effect score but suppressed expression Mmp13 Col3a1 genes in articular cartilage....
Previous studies have shown amrubicin (AMR) to be an effective second-line treatment option for small-cell lung cancer (SCLC). However, the efficacy of AMR in elderly patients with relapsed SCLC has not been sufficiently evaluated.The medical records who received as chemotherapy were retrospectively reviewed, and their outcomes evaluated.Thirty-one a median age 72 years (22 sensitive relapse 9 refractory relapse) analyzed. The number cycles was four (range: 1-10), response rate 29%....
Biotin is an essential micronutrient, and a cofactor for several carboxylases that are involved in the metabolism of glucose, fatty acids, amino acids. Because plant cells can synthesize their own biotin, wide variety plant-based foods contains significant amounts biotin; however, influence environmental conditions on biotin content plants remains largely unclear. In present study, we investigated effects different cultivation synthesis pea sprouts (Pisum sativum). experiment, were removed...
Abstract A new synthetic steroid, 17α-acetoxy-chloro-2-oxa-4,6-pregnadiene-3,20-dione (osaterone acetate, TZP-4238), has a potent antiandrogenic and gestagenic action with virtually no estrogenic androgenic activity in their classical target organs. In the present study, effects of TZP-4238 on structure, strength, turnover rat long bones were examined. Female Wistar rats at 12 weeks age ovariectomized (OVX) treated or 17β-estradiol (E2) every day for weeks. significantly increased diameters...
Collagen peptides (CPs) are bioactive molecules that have beneficial effects on bone metabolism and against joint disorders. In the present study, we investigated effect of CP supplementation visceral fat mass plasma lipid concentrations in high-fat diet (HFD)-induced obese mice. Male ddY mice were fed a normal or HFD for 3 wk, assigned to N NCP groups F FCP groups, respectively. The group administered experimental diets containing 25 mg/g CPs wk further. During period, affected neither food...
Asimina triloba (pawpaw) contains various bioactive alkaloids and acetogenins. In the present study, effects of pawpaw seed extract (PSE) on adipocyte differentiation fat accumulation were investigated in 3T3-L1 cells under different glucose conditions. Treatment undifferentiated with 10 ng/mL PSE increased lactic acid production, suggesting enhanced anaerobic glycolysis. treatment also suppressed cell proliferation decreased nicotinamide adenine dinucleotide (NAD)+/NADH ratio low-glucose...
Taste perception is affected by various environmental factors. In the present study, we investigated effects of visual and aromatic stimulations on stress responses taste perception. Fourteen young healthy participants were assessed for levels intensities under 5 different conditions: normal (no stimuli), watching an action scene, a forest sniffing rosemary aroma, lavender aroma. Compared to scene condition, or aroma condition showed significantly lower levels. Furthermore, increased...