A5023798326- Liver Disease Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Melanoma and MAPK Pathways
- Cancer Mechanisms and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune cells in cancer
- Cancer-related gene regulation
- Immunotherapy and Immune Responses
- Protein Degradation and Inhibitors
- Advanced Glycation End Products research
- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
- Flavonoids in Medical Research
- Polyomavirus and related diseases
- ATP Synthase and ATPases Research
- Metabolism and Genetic Disorders
- Chemotherapy-induced organ toxicity mitigation
- Ocular Oncology and Treatments
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Management of metastatic bone disease
- Medical Imaging and Pathology Studies
- Arsenic contamination and mitigation
- Bone health and treatments
Soochow University
2014-2025
First Affiliated Hospital of Soochow University
2014-2025
Second Affiliated Hospital of Soochow University
2024-2025
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2024
Baotou Medical College
2021
Beckman Research Institute
2020
City of Hope
2020
City Of Hope National Medical Center
2020
Xi'an Jiaotong University
2010-2013
Second Affiliated Hospital of Xi'an Jiaotong University
2010-2012
Baicalein, a widely used Chinese herbal medicine, has historically been in anti-inflammatory and anti-cancer therapies. However, the anti-metastatic effect molecular mechanism(s) of baicalein on hepatocellular carcinoma (HCC) remain poorly understood. Therefore, purpose this study was to assess effects related HCC. Based assays utilized both HCC cell lines an animal model, we found that inhibited tumor metastasis vivo vitro. Furthermore, after treatment with for 24 hours, there decrease...
// Yixiang Mao 1,* , Wei Li Kai Chen 1 Yufeng Xie Qiang Liu 2 Min Yao 3 Weiming Duan Xiumin Zhou Rongrui Liang and Tao 1,4 Department of Oncology, the First Affiliated Hospital Soochow University, Suzhou, China Pathology, Renji Hospital, Shanghai Jiaotong University School Medicine, Shanghai, Punan 4 Jiangsu Institute Clinical Immunology, * These authors contributed equally to this work Correspondence: Tao, email: Keywords : B7-H1, B7-H3, non-small cell lung cancer, prognosis Received...
Tumour cells possess a multitude of chemoresistance mechanisms, which could plausibly contribute to the ineffectiveness chemotherapy. O6-methylguanine-DNA methyltransferase (MGMT) is an important effector protein associated with Temozolomide (TMZ) resistance in various tumours. To some extent, expression level MGMT determines sensitivity TMZ, but mechanism its regulation has not been fully elucidated. Cultured malignant melanoma cell lines A375 and Sk-MEL28 were employed. A luciferase assay...
Recurrence of bladder cancer following transurethral resection tumor (TURBt) is an obstacle in clinical management. In the current study, we investigated antitumor activity baicalein, a Chinese herbal medicine, against T24 cells vitro. Baicalein inhibited growth and caused G1/S arrest cell cycle cells. Moreover, baicalein induced apoptosis via loss mitochondrial transmembrane potential (ΔΨm), release cytochrome c activation caspase-9 caspase-3. Akt phosphorylation, downregulated Bcl-2...
Abstract Background Lung cancer is with the highest morbidity and mortality in world poses a serious threat to human health. Therefore, discovering new treatments urgently needed improve lung prognosis. Small molecule inhibitors targeting ubiquitin-proteasome system have achieved great success, which deubiquitinase broad clinical applications. The deubiquitylase OTUD3 was reported promote tumorigenesis by stabilizing oncoprotein GRP78, implying that inhibition of may be therapeutic strategy...
Diallyl disulfide (DADS) is a natural organosulfur compound isolated from garlic. DADS has various biological properties, including anticancer, antiangiogenic, and antioxidant effects. However, the anticancer mechanisms of in human esophageal carcinoma have not been elucidated, especially vivo. In this study, MTT assay showed that significantly reduced cell viability ECA109 cells, but was relatively less toxic normal liver cells. The pro–apoptotic effect on cells detected by Annexin...
Abstract Background Microwave ablation (MWA) is widely used to treat unresectable primary and secondary malignancies of the liver, a limited number studies indicate that can cause not only necrosis at in situ site but also an immunoreaction whole body. This study aimed investigate effects MWA on cytokines patients who underwent for hepatic malignancy. Methods Patients admitted Oncology Department First Affiliated Hospital Soochow University between June 2015 February 2019 were selected....
The high mortality figures for hepatocellular carcinoma (HCC) are mostly due to recurrence and metastasis rates. However, the metabolic characteristics of HCC have not been studied extensively. In this study, we attempted elucidate metabolite profile formation through proton nuclear magnetic resonance (1H-NMR)-based metabolomics. We first established a with lung (HLM) rat model by exposure diethylnitrosamine. Fifteen rats were then divided into three groups based on pathologic changes: HCC,...
Hypersplenism is a condition in which the spleen overactive. It common patients with cirrhosis-related portal hypertension. The over-activated hemophagocytic splenic macrophages are an important cause of hypersplenism. MicroRNAs (miRNAs) 21-22 nt single-stranded RNAs expressed endogenously, play roles many diseases. We have found by microarray, previously, that miR-615-3p highly In this study, we enhanced phagocytic capacity macrophages. Bioinformatics analysis indicated ligand-dependent...
Background: Hepatocellular carcinoma (HCC) is the fourth most common malignant tumor in China. Temozolomide (TMZ) a chemotherapy drug which can effectively kill HCC cells vitro. However, it possible that possess intrinsic resistance to TMZ. A key mechanism of TMZ overexpression O6-methylguanine-DNA methyltransferase (MGMT). Studies have shown MAPK may be related MGMT expression, U0126 highly selective inhibitor MEK1 and MEK2, were crucial molecule cascade mitogen-activated protein...
Angiogenesis is a critical step of breast cancer metastasis. Oncogenic Ras promotes the remodeling microenviroment. Tumor-associated macrophages (TAMs) are prominent inflammatory cell population emerging in microenviroment and facilitating angiogenesis In present study, we tried to investigate relationship between expression infiltration TAM, both which could further promote angiogenesis. Expressions Ras, CD68 CD34 were assessed by immunohistochemistry. The was evaluated counting number...
FH535 is a small-molecule inhibitor of the Wnt/β-catenin signaling pathway, which substantial body evidence has proven activated in various cancers, including pancreatic cancer. Activation pathway plays an important role tumor progression and metastasis. We investigated inhibitory effect on metastasis growth cancer cells. Western blotting luciferase reporter gene assay indicated that markedly inhibited viability In vitro wound healing, invasion, adhesion assays revealed significantly cell...
Malignant gliomas consist of heterogeneous cellular components that have adopted multiple overlapping escape mechanisms overcome both targeted and immune-based therapies. The receptor for advanced glycation end products (RAGE) is a member the immunoglobulin superfamily activated by diverse proinflammatory ligands present in tumor microenvironment. Activation RAGE its stimulates signaling pathways are important growth invasion. However, treatment strategies only target interaction with...
Malignant pleural mesothelioma (MPM) chemoresistance remains a challenge to oncologists. In our previous study, we demonstrated that the aberrant expression of metastasis-associated gene 1 (MTA1) is associated with carcinogenesis and metastasis in MPM. The aim present study was investigate mechanism MTA1 chemo-resistance MPM.Western blotting real-time polymerase chain reaction were used analyze protein mRNA levels. A stable clone knockdown generated shRNA via lentivirus technology MPM cell...
Background: Bone is among the most common metastasis sites in patients with advanced cancer. Approximately two-thirds of bone results pain, majority which moderate to unbearable seriously affects quality life patients. With development ablation techniques, microwave (MWA) has great potential eliminate pain caused by metastasis. This study aimed evaluate efficacy and safety image-guided (computed tomography-guided) percutaneous MWA for metastatic osseous pain. Methods: a retrospective...
Abstract INTRODUCTION Malignant gliomas consist of heterogenous cellular components that have adopted multiple overlapping escape mechanisms overcome both targeted and immune-based therapies. The receptor for advanced glycation end products (RAGE) is a member the immunoglobulin superfamily activated by diverse proinflammatory ligands present in tumor microenvironment (TME). Activation RAGE its stimulates signaling pathways are important growth, invasion, immune escape. OBJECTIVE We aimed to...
INTRODUCTION: Malignant gliomas consist of heterogenous cellular components that have adopted multiple overlapping escape mechanisms overcome both targeted and immune-based therapies. The receptor for advanced glycation end products (RAGE) is a member the immunoglobulin superfamily activated by diverse proinflammatory ligands present in tumor microenvironment (TME). Activation RAGE its stimulates signaling pathways are important growth, invasion, immune escape. METHODS: We evaluated genetic...
Objective To investigate the effect of Chrysanthemum indicum extract(CIE)on proliferation and apoptosis hepatocellular carcinoma(HCC)MHCC97H cells explore its mechanism.Methods MHCC97H cultured in vitro,pretreatment with CIE 0.4,0.8,1.2 mg/ml blank control group,proliferation was measured by microculture tetrazolium(MTT).Cell mitochondrial membrane potential(MMP ΔΨm)were determined flow cytometry.Cytochrome C,Caspase-9 and-3 expression Western blot.Results significantly inhibited a dose-and...