A5075647380- Cytokine Signaling Pathways and Interactions
- Chemokine receptors and signaling
- Cancer, Lipids, and Metabolism
- Immunotherapy and Immune Responses
- Inflammatory mediators and NSAID effects
- PI3K/AKT/mTOR signaling in cancer
- Kruppel-like factors research
- Gastric Cancer Management and Outcomes
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- Esophageal Cancer Research and Treatment
- Sarcoma Diagnosis and Treatment
- Esophageal and GI Pathology
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Advanced MRI Techniques and Applications
- Bone Tumor Diagnosis and Treatments
- Cancer-related gene regulation
- Lung Cancer Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Myofascial pain diagnosis and treatment
- Cancer, Stress, Anesthesia, and Immune Response
- HER2/EGFR in Cancer Research
First Affiliated Hospital of Bengbu Medical College
2019-2024
Bengbu Medical College
2019-2023
Anhui Medical University
2023
Gansu Provincial Hospital
2015-2020
Nagoya City University
2007-2012
The tumour suppressor phosphatase and tensin homolog (PTEN) is an important negative regulator of cell-survival signaling. To evaluate the correlation between PTEN expression clinicopathological characteristics colorectal cancer patients with without liver metastases, we investigated in primary metastases.Sixty-nine pairs corresponding metastasis specimens were analyzed immunohistochemically, immunohistochemical findings factors was investigated. Seventy from metastases used as controls.PTEN...
Abstract Background Stromal-derived CXCL12 play an important role which influence the proliferation and invasiveness of colon cancer in microenvironment. The present study aimed to analyze underlying mechanism by tumour suppressor protein phosphatase tensin homologue deleted on chromosome 10 (PTEN) influences metastatic potential internal relation stromal cells. Methods RT-PCR western blot were detected expression CXCL12, CXCR4 PTEN cells co-operative effects invasion evaluated real-time...
Abstract Background and Objectives Interleukin (IL)‐1α plays an important role in colon cancer progression angiogenesis. We here asked whether IL‐1α derived from cells modulates vascular endothelial cell growth, migration tubule formation. Methods The existence of mRNA protein lines (WiDr, HT‐29, Caco‐2, COLO 320) were investigated with RT‐PCR ELISA. Proliferation invasion by MTS assay Matrigel‐double chamber assay. To answer our main question, we performed angiogenesis used vitro model...
Abstract Background and Objectives Interleukin (IL)‐1α hepatocyte growth factor (HGF) play an important role in pancreatic cancer proliferation, angiogenesis, invasiveness. The aim of this study was to investigate the cooperative HGF IL‐1α metastatic processes promoted by interactions between cells stromal cells. Methods Expression mRNA protein determined RT‐PCR ELISA. effect on potential evaluated invasion, angiogenesis assays using vitro system consisting co‐cultured tumor Results...
To investigate the underlying mechanism by which CXCL12 and CXCL6 influences metastatic potential of colon cancer internal relation stromal cells.Western blotting was used to detect expression in cells cells. The co-operative effects on proliferation invasion human umbilical vein endothelial (HUVECs) were determined enzyme-linked immunosorbent assay, assays. angiogenesis HUVECs through interaction with examined assay. We eventually investigated activation PI3K/Akt/mTOR signaling involved...
To investigate the effect of CXCL12 gene silencing on proliferation,invasion, angiogenesis and relationship MAPK/PI3K/AP-1 signaling pathway in colon cancer cells. RT-PCR Western-blot were used to detect expression mRNA protein four cell lines. Human cells transfected with siRNA carrying by Lipofectamine 2000. The was confirmed immunoblotting. WST-1, invasion assay examine proliferation, after silence, respectively. phosphorylation levels detected Western blotting suppression DLD-1 cell....
Interleukin-1 alpha (IL-1α) plays an important role in tumorigenesis and angiogenesis of gastric cancer. The interleukin-1 receptor antagonist (IL-1RA) inhibits IL-1 selectively specifically through IL-1R type I (IL-1RI). However, the underlying mechanism by which IL-1RA modulates interactions tumor cells their micro-environment is poorly understood. We have evaluated metastatic process as well mutual or reciprocal actions between cancer stromal cells.The expressions IL-1α, vascular...
Purpose: This article investigates the relationship between cancer cells and stromal in carcinoma cell living microenvironment elucidates mechanism that interleukin-1 receptor antagonist (IL-1RA) blocks metastatic potential colon cancer. Methods: Western blot RT-PCR assay were used to determine expression of hepatocyte growth factor (HGF) IL-1α cells. Effect IL-1RA HGF on examined by proliferation, invasion, angiogenesis assays. The interactional role detected ELISA assay, making up a...
Susceptibility-weighted imaging (SWI) is based on a 3D high-spatial-resolution, velocity-corrected gradient-echo MRI sequence that uses magnitude and filtered-phase information to create images. It SWI tissue magnetic susceptibility differences generate signal contrast may arise from paramagnetic (hemosiderin), diamagnetic (minerals calcifications) ferromagnetic (metal) molecules. Distinguishing between calcification blood products possible through the filtered phase images, helping...
Gastric cancer (GC) remains a major public health problem. Ursolic acid (UA) is reported to be effective in inhibiting GC; however, its low solubility and poor biocompatibility have greatly hindered clinical application. Herein, an innovative reactive oxygen species (ROS)-sensitive UA dimeric prodrug developed by coupling two molecules via ROS-cleavable linkage, which can self-assemble into stable nanoparticles the presence of surfactant. This new UA-based delivery system comprises following...
This study aims to investigate the effects of ω-3, ω-6 polyunsaturated fatty acids (PUFAs), and their middle metabolites prostaglandin (PGE)2 PGE3 on proliferation, invasion, angiogenesis formation gastric cancer cells explore associated mechanism.RT-PCR ELISA were used detect expression cyclooxygenase (COX)-1 COX-2 in cell lines. The effect ω-6, PGE2, measured by assay vitro. small interfering RNA (siRNA) was transfected into cells, protein detected Western blot. gene silencing influencing...
4012 Background: Anti-PD-1 monoclonal antibody (mAbs) plus chemotherapy has become standard first-line therapy for patients (pts) with advanced/metastatic G/GEJ cancer. In this phase Ib/II study (NCT04982276), we assessed the safety and efficacy of cadonilimab, a PD-1/CTLA-4 bispecific antibody, in combination pulocimab, an anti-VEGFR-2 mAb, paclitaxel cancer pts who failed immunochemotherapy. Methods: This consisted two parts: run-in (arms A, B C, n = 6 each) expansion (a randomized,...
Purpose: This study aimed to determine the relevance of first- and high-order radiomic features derived from Diffusion-Weighted Imaging (DWI) Apparent Diffusion Coefficient (ADC) maps for predicting treatment response in patients with Undifferentiated Pleomorphic Sarcoma (UPS). Methods: retrospective included 33 extremity UPS pre-surgical DWI/ADC surgical resection. Manual volumetric tumor segmentation was performed on acquired at Baseline (BL), Post-Chemotherapy (PC), Post-Radiation Therapy...
To better explore the underlying mechanism of liver metastatic formation by placenta-specific protein 1 (PLAC1) in human colorectal cancer, we investigated proliferation, invasion and angiogenic capabilities cancer cells with different potentials as well action PLAC1 process. The expression was detected reverse transcriptase PCR, western blot, real-time PCR. effect on potential determined invasion, angiogenesis assays, including an in-vitro coculture system consisting vascular endothelial...
Abstract Background The aim of this study was to investigate the co-operative role CXCR4/CXCL12 axis and IL-1Ra in metastatic processes mechanism by interactions between colorectal cancer cells stromal their microenvironment. Methods Expression IL-1α, interleukin-1 receptor type I (IL-1 RI), CXCL12 CXCR4 mRNA proteins were determined RT-PCR Western blot. effect secreted level on fibroblasts measured ELISA. regulate potential evaluated proliferation, invasion angiogenesis assays,...
This study aimed to analyze the stage-situation depression and anxiety as well independent influential factors in patients with postsurgical gastroparesis syndrome (PGS) provide dependent indications for treatment.The self-rating scale (SDS) (SAS) were used test of 53 PGS, who treated Department Gastroenterological Surgery Gansu Provincial Hospital from January 2012 October 2016. A comparison between SDS or SAS scores PGS without was undertaken; then, we retrospectively analyzed influencing...
The purpose of paper is to investigate the depression and anxiety as well independent influential factors between patients who underwent Da Vinci robot-assisted radical gastrectomy gastrectomy. This study a partially randomized patient preference trial. A total 98 with gastric cancer were divided into group (46 patients, observation group) open (52 control group). They also postoperatively preoperatively measured Self-Rating Depression Scale (SDS) Anxiety (SAS). postoperative preoperative...