A5102719914- Prostate Cancer Treatment and Research
- Gastric Cancer Management and Outcomes
- Prostate Cancer Diagnosis and Treatment
- Genomics, phytochemicals, and oxidative stress
- Asthma and respiratory diseases
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Synthesis and biological activity
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related molecular mechanisms research
- Genetic Associations and Epidemiology
- Multiple and Secondary Primary Cancers
- Plant-based Medicinal Research
- Cancer, Stress, Anesthesia, and Immune Response
- Computational Drug Discovery Methods
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Medical Imaging Techniques and Applications
- Metastasis and carcinoma case studies
- Synthesis of β-Lactam Compounds
- Bioactive Natural Diterpenoids Research
- Autophagy in Disease and Therapy
- MRI in cancer diagnosis
- Nanoparticle-Based Drug Delivery
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
First Affiliated Hospital of Bengbu Medical College
2018-2025
Shandong University of Traditional Chinese Medicine
2025
First Affiliated Hospital of Jinan University
2025
NorthShore University HealthSystem
2020-2024
Guangzhou University of Chinese Medicine
2024
Bengbu Medical College
2023
Chinese Academy of Medical Sciences Dermatology Hospital
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Soochow University
2017-2019
Shanghai East Hospital
2014
Sulforaphane (SFN) extracted from broccoli sprout has previously been investigated for its potential properties in cancers, however, the underlying mechanisms of anticancer activity SFN remain not fully understood. In present study, we investigate effects on cell proliferation, cycle, apoptosis, and also expression several cycle apoptosis-related genes by MTT assay, flow cytometry western blot analysis gastric cancer (GC) cells. The results showed that could impair colony-forming ability...
Systemic immune-inflammation index (SII), based on peripheral lymphocyte, neutrophil, and platelet counts, was recently investigated as a prognostic marker in several tumors. However, SII has not been reported nasopharyngeal carcinoma (NPC). We evaluated the value of 327 patients with NPC. Univariate multivariate analyses were calculated by Cox proportional hazards regression model. The time-dependent receiver operating characteristics (ROC) curve used to compare discrimination ability for...
Background Shenfu injection (SFI), derived from a traditional Chinese medicine (TCM) prescription, is an effective drug for the treatment of sepsis-induced myocardial injury (SIMI) with good efficacy, but its exact therapeutic mechanism remains unclear. Methods SwissTargetPrediction and GeneCards database were used to obtain relevant targets SFI SIMI. STRING 11.5 MCODE analyse potential SFI. DAVID 6.8 was perform enrichment analysis. In addition, SIMI model constructed by cecal ligation...
This study aimed to screen the changes after overexpression of dCTP pyrophosphatase 1 (DCTPP1) in human gastric adenocarcinoma cells (AGS) by proteome and transcriptome sequencing. Gene Ontology Kyoto Encyclopedia Genes Genomes enrichment analysis were performed explore functional significance differentially expressed DCTPP1 cancer (GC). Cell Counting Kit-8 (CCK-8) assay was used detect proliferation cells. Western blot expression proteins. A total 28 genes that significantly associated with...
Cu 2 S nanocube-implanted 3D bead-like nitrogen-doped carbon nanofiber fabric has been successfully fabricated and employed as an interlayer to protect the lithium metal anode.
To study the effects of cortactin on tumor biology SGC-7901 cells and identify mechanism involved in process.Cell lines which was stably overexpressed or knocked down as well respective control cell were established by standard molecular methods. The proliferation, migration invasion capacity assessed MTT assay, colony formation, flow cytometry, transwell matrigel invasion. Nude mouse models also used to assess role growth metastasis vivo. Western blotting analysis performed detect...
Colorectal cancer (CRC) is a common human malignancy that accounts for 600,000 deaths annually worldwide. Chrysophanol, naturally occurring anthraquinone compound, exhibits anti‐neoplastic effects in various cells. The aim of this study was to explore the biological chrysophanol on CRC cells, and determine underlying mechanism. Chrysophanol inhibited proliferation promoted apoptosis cells by activating intrinsic mitochondrial apoptotic pathway. In addition, also suppressed tumor growth vivo...
ABSTRACT Colorectal cancer (CRC) is a common human malignancy, accounting for 600,000 death cases annually worldwide. Chrysophanol naturally occurring anthraquinone compound and exhibits anti‐neoplastic activities. This study aims to explore the biological effects of chrysophanol on CRC metastasis relevant underlying mechanism. Cell proliferation assay, wound scratch Transwell invasion assay were used examine effect proliferation, migration, cells. Hypoxia‐inducible factor‐1α (HIF‐1α) shRNA...
Abstract Background Prostate cancer (PCa) is characterized by its tendency to be multifocal. However, few studies have investigated the endogenous factors that explain multifocal disease. The primary objective of current study test whether inherited PCa risk associated with tumors in patients. Methods Subjects this were patients European ancestry undergoing active surveillance at Johns Hopkins Hospital ( N = 805) and NorthShore University HealthSystem 432). was measured genetic score (GRS),...
It has been estimated that nearly one‐third of functional proteins contain a metal ion. These constitute wide variety possible drug targets including metalloproteinases, dehydrogenases, oxidoreductases, hydrolases, deacetylases, or many others in which the ion is either catalytic structural nature. Despite predominant role so classes targets, current high‐throughput screening techniques do not usually produce viable hits against these proteins, likely due to lack proper metal‐binding...
Abstract Germline HOXB13 G84E mutation has been consistently associated with prostate cancer (PCa) risk, but its association other cancers is controversial. We systematically tested the 20 most common types in subjects from UK Biobank. The was found 1,545 (0.34%) of 460,224 participants European ancestry. While status did not associate risk females, it significantly increased males; odds ratio (OR) (95% confidence interval) for overall diagnosis 2.19 (1.89–2.52), P = 2.5E-19. remained after...
ABSTRACT Atypical diabetes with overlapping clinical features of type 1 (T1D) and 2 (T2D) is common challenging diagnostically for implementing effective treatment. Here, we validate a recently reported genetic probability (GenProb‐T1D) from the UK Biobank (UKB) differentiating in patient cohort healthcare system‐based biobank USA. Among 3,363 patients, confirmed performance GenProb‐T1D typical vs diabetes. Furthermore, 359 atypical those higher than pre‐defined cutoff derived UKB had...
The current study aimed to explore the prognostic role of preoperative prealbumin in resectedesophageal squamous cell carcinoma (ESCC).A total 1374 resected ESCC patients were retrospectively reviewed. Serum for analyses was taken within 1-3 days before operation. Overall survival (OS) determined using Kaplan-Meier method; univariate log-rank test and multivariate Cox proportional hazard model used evaluate prealbumin. A receiver operating characteristic (ROC) curve plotted, area under (AUC)...
Abstract Although cancer has been associated with COVID-19 risk and mortality in hospital-based studies, few population-based studies have reported. Utilizing data from the UK Biobank (UKB), a prospective cohort, we formally tested association of over 44 different types infection among 7,661 subjects who were by June 17, 2020. Compared to non-cancer subjects, (N=1,521) had significantly lower overall for [odds ratio (OR) 95% confidence interval (CI): 0.79 (0.68-0.92), P =2.60E-03]. However,...
Individual variation in pharmacokinetics of faropenem is significant. We attempted to predict drug response using a pharmacometabonomic approach. Metabolic profiling was performed on predose plasma samples from 36 healthy volunteers by gas chromatography–mass spectrometry (GC/MS), with 204 endogenous metabolites detected. Plasma concentration measured after administration, high pressure liquid chromatography-tandem mass spectroscopy (LC/MS/MS), and the pharmacokinetic parameters were...