A5045734819- Microtubule and mitosis dynamics
- Ubiquitin and proteasome pathways
- DNA Repair Mechanisms
- Molecular Biology Techniques and Applications
- Innovation and Knowledge Management
- Anesthesia and Sedative Agents
- Monoclonal and Polyclonal Antibodies Research
- Mental Health Treatment and Access
- Hospital Admissions and Outcomes
- CRISPR and Genetic Engineering
- Schizophrenia research and treatment
- Erythrocyte Function and Pathophysiology
- Kruppel-like factors research
- University-Industry-Government Innovation Models
- Nutrition, Genetics, and Disease
- Traumatic Brain Injury and Neurovascular Disturbances
- Veterinary Pharmacology and Anesthesia
- Prostate Cancer Treatment and Research
- Cellular transport and secretion
- Animal Genetics and Reproduction
- Nursing Diagnosis and Documentation
- Receptor Mechanisms and Signaling
- Mental Health and Psychiatry
- Mental Health and Patient Involvement
- Nursing education and management
SignPath Pharma (United States)
2021-2025
Hong Kong Baptist University
2020-2024
Center for Cancer Research
2013-2024
National Cancer Institute
2012-2024
National Institutes of Health
2022-2024
Integrative Clinical Trials
2024
Flinders University
2022-2024
Southwest Forestry University
2023-2024
Yale University
2008-2023
Changsha Central Hospital
2023
Aims Angiotensin converting enzyme (ACE) 2 catalyses the cleavage of angiotensin (Ang) I to Ang 1‐9 and II 1‐7. ACE2 deficiency impairs cardiac contractility upregulates hypoxia-induced genes, suggesting a link with myocardial ischaemia. We studied expression after infarction (MI) in rat as well human failing hearts.
Abstract Aim To report a concept analysis of nursing‐sensitive indicators within the applied context acute care setting. Background The ‘nursing sensitive indicators’ is valuable to elaborate nursing performance. conceptual foundation, theoretical role, meaning, use and interpretation tend differ. elusiveness ambiguity its attributes may have hindered research efforts advance application in practice. Design Concept analysis. Data sources Using ‘clinical or ‘quality care’ as subject headings...
Abstract The tumor suppressor BRCA2 participates in DNA double-strand break repair by RAD51-dependent homologous recombination and protects stressed replication forks from nucleolytic attack. We demonstrate that the C-terminal Recombinase Binding (CTRB) region of BRCA2, encoded gene exon 27, harbors a binding activity. CTRB alone stimulates strand exchange activity RAD51 permits utilization RPA-coated ssDNA for exchange. Moreover, functionally synergizes with Oligonucleotide fold containing...
Aurora-A is a conserved kinase implicated in mitotic regulation and carcinogenesis. was previously entry spindle assembly, although contradictory results prevented clear understanding of the roles mammals. We developed conditional null mutation mouse gene to investigate functions primary cells ex vivo vivo. show here that ablation cultured embryonic fibroblasts causes impaired arrest with profound defect bipolar formation. Germ line deficiency death at blastocyst stage pronounced cell...
Bacteria produce extracellular enzymes to obtain resources from complex chemical substrates, but this strategy is vulnerable cheating by cells that take up reaction products without paying the cost of enzyme production. We hypothesized would suppress production in co-cultures cheater and producer bacteria, particularly under well-mixed conditions. To test hypothesis, we monitored protease expression frequencies Pseudomonas fluorescens genotypes over time mixed liquid cultures on agar plates....
This review compiles different analytical methods reported by the researchers studying heavy metal contents in seaweed samples from a variety of natural and commercial sources. Heavy metals affect environmental health human due to seaweed’s role aquatic food chain consumption. The potential for presence is industrial pollution other activities. There an ongoing demand evaluation nutritional as well hazardous raw processed seaweeds. article will look at importance usage seaweed, measuring...
Abstract Bub1 is a serine/threonine kinase originally described as core component of the spindle assembly checkpoint (SAC) mechanism in yeast. binding at kinetochores has been reported to be required for SAC function and localization other components. A proper believed essential murine embryonic development, all previously null mutations components mice cause lethality. We produced harboring mutant allele lacking exons 2 3, resulting hypomorphic expressed <5% wild-type levels. Despite...
The BLAP75 protein combines with the BLM helicase and topoisomerase (Topo) IIIα to form an evolutionarily conserved complex, termed BTB that functions regulate homologous recombination. binds DNA, associates both Topo IIIα, enhances ability of BLM-Topo pair branch migrate Holliday junction (HJ) or dissolve double (dHJ) structure yield non-crossover recombinants. Here we seek understand relevance biochemical attributes in HJ processing. With use a series fragments, show N-terminal third...
Poor adherence to medications is common in individuals with schizophrenia, and can lead relapse re‐hospitalization. This paper presents the findings of an Australian study factors affecting antipsychotic medication taking schizophrenia. The Factors Influencing Neuroleptic Medication Taking Scale was used a non‐probability sample mental health service users. Ethics approval obtained from university hospital ethics committee. Data were analysed using spss version 15. Most participants had...
Objective To obtain a comprehensive understanding of long-term outcome after severe traumatic brain injury (sTBI). Participants Forty-six patients with sTBI. Design Comparison interdisciplinary evaluation results at discharge from acute care and 2 to 5 year follow-up. Main Measures Extended Glasgow Outcome Scale, the FIM™ instrument, Neurobehavioral Rating Scale-Revised. Results Significant improvement was observed on 3 factors These measures were significant predictors outcome. Conclusion...
Kerr D, Lu S, McKinlay L, Fuller C. International Journal of Nursing Practice 2011; 17 : 342–350 Examination current handover practice: Evidence to support changing the ritual Examining systems nursing provides opportunity identify areas in need improvement and modification. The aim this study was describe practices for one organization explore clinical nurses' opinions regarding quality shift‐to‐shift style. One hundred fifty‐three registered nurses employed 23 wards an acute tertiary...
To meet the demand for rapid synthesis of chorion (eggshell) proteins, Drosophila ovarian follicle cells amplify chromosomal loci containing gene clusters up to 60-fold. Amplification occurs by repeated firing one or more origins located within each cluster. Deletion analyses transgenic constructs derived from third chromosome cluster have identified a 320-bp amplification control element (ACE3) required amplification, as well several stimulatory enhancing regions (AERs). Two-dimensional...
Abstract
Abstract Purpose – The purpose of this paper is to outline the strategic challenges for creating knowledge‐based innovation in China. Design/methodology/approach outlines context China and describes triple helix model innovation. Findings China's re‐emergence as a major power world economy points needs integrating into global networks. However, there are number facing Chinese firms, academics, government agencies policy makers. Originality/value gives notice launch 2009 Journal...
Many students have poor mental health literacy when they finish Bachelor of Nursing courses. This paper presents the findings a longitudinal study Australian students' about effectiveness interventions for people with schizophrenia. The ‘Attitudes and Beliefs Mental Health Problems: Professional Public Views’ questionnaire was used non‐probability sample nursing students. A time series approach to data collection used, collected on three occasions between 2005 2007. Ethics approval obtained...
Within the context of contemporary nursing practice, bedside handover has been advocated as a potentially more suitable mode for achieving patient‐centred care. Given that patients can play an important role in process, better understanding patients' perspectives could be critical determinate successful implementation practice. Using phenomenological approach, this study attempted to explore perceptions handover. Four key themes emerged from patient interviews: ‘a effective and personalised...
Serum level of interleukin 6 (IL-6) is known to be associated with postoperative delirium. However, no consensus has emerged on the time point at which IL-6 may predict delirium after coronary artery bypass graft surgery.To compare trends in levels patients and without examine relationship between different times graft.A prospective cohort study who underwent their first elective isolated November 2013 August 2015 a cardiac intensive care unit Beijing, China. Concentrations were measured...