A5007340554- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Cardiovascular and Diving-Related Complications
- Spinal Fractures and Fixation Techniques
- Pelvic and Acetabular Injuries
- Cardiovascular Health and Disease Prevention
- Tendon Structure and Treatment
- Pregnancy-related medical research
- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Regulation of Appetite and Obesity
- Sleep and related disorders
- Tracheal and airway disorders
- Vascular Anomalies and Treatments
- Hip and Femur Fractures
- Sleep and Wakefulness Research
- Pulmonary Hypertension Research and Treatments
- Shoulder Injury and Treatment
- Orthopedic Surgery and Rehabilitation
- Chronic Obstructive Pulmonary Disease (COPD) Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Peking Union Medical College Hospital
2020-2025
China-Japan Friendship Hospital
2024-2025
Chinese PLA General Hospital
2023-2024
Central Hospital of Wuhan
2023-2024
Huazhong University of Science and Technology
2023-2024
Abstract Background and Objective The apnoea‐hypopnoea index (AHI) oxygen desaturation (ODI) encounter challenges in capturing the intricate relationship between obstructive sleep apnoea (OSA) cardiovascular disease (CVD) risks. Although novel hypoxic indices have been proposed to tackle these limitations, there remains a gap comprehensive validation comparisons across unified dataset. Methods Samples were derived from Sleep Heart Health Study (SHHS), involving 4485 participants aged over 40...
WXSH0208 is a selective inhibitor of influenza RNA polymerase subunit, demonstrating antiviral activity in preclinical studies against A and B virus infections. The purpose this study was to investigate the efficacy safety adult outpatients with uncomplicated influenza. We conducted multicenter phase 2 trial based on randomized, double-blind, placebo-controlled design at 23 research centers China from November 2023 March 2024. Participants were randomized 1:1:1:1 receive one following...
Idiopathic scoliosis (IS) is the most common spinal deformity and often accompanied by abnormal respiratory function. This study investigated correlations among radiographic parameters, pulmonary function tests, sleep-breathing monitoring in patients with IS. The clinical data of IS admitted to our hospital for surgery between January 2020 March 2022 were retrospectively collected. Radiographic measurements, including thoracic malformation performed. Pulmonary measurements results collected...
Obstructive sleep apnea (OSA) is related to multiple complications including insulin resistance (IR), endothelial dysfunction, and increased risk of cardiovascular disease (CVD). The apnea-hypopnea index (AHI) was widely used measure OSA severity but poorly correlated with above. This study aimed evaluate whether a new metric, the breathing impairment (SBII), associated in patients OSA.This enrolled 140 consecutive male without overt atherosclerotic CVD events, coronary heart disease,...
To investigate the effectiveness of HoloSight Orthopaedic Trauma Surgery Robot-assisted infra-acetabular screw placement for treatment acetabular fractures.
In this study, we aimed to investigate the precise relationship between hypoxia-inducible factor 1α (HIF1α), circadian clock genes, and OSA.
Objective: An effective clinical tool to assess endothelial function and arterial stiffness in patients with obstructive sleep apnea (OSA) is lacking. This study evaluated the significance of subclinical markers for OSA management males without serious complications. Patients/Methods: Males complications were consecutively recruited. Clinical data, biomarker tests, reactive hyperemia index (RHI), augmentation at 75 beats/min (AIx75) measured by peripheral tonometry collected. hypopnea (AHI)...
Abstract Background Stenosis and obliteration of the pulmonary vein can be developed by multiple diseases might cause hemoptysis. Traditional therapy including surgical procedure conservative treatments inappropriate choices to manage massive Case presentation A 64-year-old man, diagnosed with advanced stage IVA lung squamous cell carcinoma, presented dyspnea recurrent, An initial contrast-enhanced computed tomography revealed a giant tumor in left hilus occlusion superior vein. Despite...
Background Endothelial dysfunction was shown to contribute significantly the elevated cardiovascular risk observed in general population. However, relationship between endothelial and subclinical myocardial injury obstructive sleep apnoea (OSA) patients remains unclear. Methods This cross-sectional study recruited 165 consecutive male diagnosed with OSA. All participants underwent overnight polysomnography confirm diagnosis assess severity of Subclinical evaluated using high-sensitivity...
To evaluate the positional relationship between protective channel and sural nerve while treating acute Achilles tendon rupture with assisted minimally invasive repair (CAMIR) technique based on anatomical observations of cadaver specimens.
To explore the difference in effectiveness between a dynamic rehabilitation protocol and traditional static after treatment of acute Achilles tendon rupture with channel assisted minimally invasive repair (CAMIR) technique through prospective comparative trial, aiming to provide reference for clinically selecting feasible regimen.
ABSTRACT Objective There are many advantages to stabilize the posterior pelvic ring injuries with a transiliac‐transsacral (TITS) screw percutaneously. To identify correct entry point and insert guidewire accurately for TITS screw, we propose method of specifying optimal point, introduce technique enabling freehand placement fluoroscopic guidance. Methods In this retrospective study, 116 patients who underwent CT scans lateral radiographs at our institution from January 2020 April 2022 were...
Using the apnea-hypopnea index (AHI) and sleep breathing impairment (SBII) to assess severity of obstructive apnea (OSA) study how effective SBII is in assessing cardiovascular disease (CVD) prognosis.
To investigate the early effectiveness of transiliac-transsacral screws internal fixation assisted by augmented reality navigation system HoloSight (hereinafter referred to as "computer system") in treatment posterior pelvic ring injuries.A retrospective analysis was made 41 patients with injuries who had been treated surgically between June 2022 and 2023. The were divided into group (18 cases, using computer assist screw implantation) freehand (23 C-arm X-ray fluoroscopy guide according...
Abstract Background Acromegaly is a multisystemic disease characterized by an excessive release of growth hormone (GH) and insulin-like factor-1. Obstructive sleep apnea (OSA) common consequence acromegaly, hypercapnia frequently observed in patients with OSA, obesity. However, the effects on acromegaly remain unknown. This study was designed to investigate whether there are differences clinical symptoms, variables, biochemical remission after surgery for OSA or without hypercapnia. Methods...