A5100379000- Salivary Gland Disorders and Functions
- Colorectal Cancer Surgical Treatments
- IgG4-Related and Inflammatory Diseases
- Cancer Immunotherapy and Biomarkers
- Parathyroid Disorders and Treatments
- Galectins and Cancer Biology
- Minimally Invasive Surgical Techniques
- Immunodeficiency and Autoimmune Disorders
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Urticaria and Related Conditions
- Microbial Natural Products and Biosynthesis
- Gastrointestinal Tumor Research and Treatment
- Autoimmune Bullous Skin Diseases
- Genetic Syndromes and Imprinting
- Antimicrobial Peptides and Activities
- Inflammasome and immune disorders
- Lung Cancer Research Studies
- Fungal Biology and Applications
- Molecular Biology Techniques and Applications
- Immune Cell Function and Interaction
- Otitis Media and Relapsing Polychondritis
- Marine Sponges and Natural Products
- Obstructive Sleep Apnea Research
- Ethics in Clinical Research
Columbia University
2023-2025
Anqing Normal University
2025
Sun Yat-sen University Cancer Center
2025
Peking University First Hospital
2025
Peking University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Peking Union Medical College Hospital
2017-2024
Chinese Academy of Agricultural Sciences
2023-2024
Agricultural Genomics Institute at Shenzhen
2024
Ministry of Education of the People's Republic of China
2022-2023
Neutrophils and aberrant NETosis have been implicated in the pathogenesis of diverse autoimmune diseases; however, their roles primary Sjögren's syndrome (pSS) remain unclear. We aimed to reveal potential neutrophils neutrophil extracellular traps (NETs) pSS.pSS patients were enrolled markers measured plasma labial glands using ELISA immunofluorescence. The gene signatures assessed by RNA-Seq RT-PCR. Reactive oxygen species (ROS), mitochondrial ROS (MitoSOX) production, JC-1 flow...
Violaceotides B–E (1–4), four new cyclic tetrapeptides, along with seven known compounds, were identified from the sponge-associated Aspergillus insulicola IMB18-072 co-cultivated marine-derived Alternaria angustiovoidea IMB20-805. Their structures elucidated by extensive analysis of spectroscopic data, including HRESIMS, 1D and 2D NMR, MS/MS data. The absolute configurations determined advanced Marfey's method. Compounds 2, 3, violaceotide A (5) displayed selective antimicrobial activities...
SUMMARY Here, we report the spatial organization of RNA transcription and associated enhancer dynamics in human spinal cord at single-cell single-molecule resolution. We expand traditional multiomic measurements to reveal epigenetically poised bivalent active transcriptional states that define cell type specification. Simultaneous detection chromatin accessibility histone modifications nuclei reveals previously unobserved cell-type specific cryptic activity, which activation is uncoupled...
Abstract Based on a sample of prefecture-level cities in China from 2004 to 2017, the policy effects “market-based mechanism”design emission reduction tools are examined. The study concludes that China's carbon emissions trading system has very significant effect, and market-based reform facilitating while reasonable corporate tax burden environmental regulation intensity have synergistic effect operational efficiency market. It is also found impact R&D behavior, but its role needs be...
Abstract Lumbar disc (LD) herniation and aging are prevalent conditions that can result in substantial morbidity. This study aimed to clarify the mechanisms connecting LD herniation, particularly focusing on cellular senescence molecular alterations nucleus pulposus (NP). We performed a detailed analysis of NP samples from diverse cohort, including individuals varying ages those with diagnosed herniation. Our methodology combined histological assessments single-nucleus RNA sequencing...
In this study, we aimed to investigate the precise relationship between hypoxia-inducible factor 1α (HIF1α), circadian clock genes, and OSA.
Abstract Objectives Immunoglobulin-G4-related disease (IgG4-RD) is a distinct systemic autoimmune-mediated manifesting as chronic inflammation and tissue fibrosis. Since the role of DNA methylation in pathogenesis IgG4-RD still unclear, we conduct this study to investigate epigenetic modifications IgG4-RD. Methods A genome-wide was conducted with B cells, CD4 + T salivary gland tissues from patients matched controls by using Illumina HumanMethylation 850K BeadChip. We further performed...
Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease characterized by B cell hyperactivation and hypergrammaglobulinemia. Currently, the role of metabolic pathways in cells pSS patients poorly defined. Here, we showed that upon cytosine phosphate-guanine (CpG)/sCD40L/IL-4 stimulation, proportionally increased glycolysis oxygen consumption, compared with from healthy controls (HCs), exhibited higher capacity maximal oxidative respiration (OXPHOS). We also found glucose...
Abstract Background Ovarian clear cell carcinoma (OCCC), well known for its chemoresistance to platinum-based chemotherapy, exhibited a good response in clinical trials of anti–PD-1/PD-L1 inhibitors. By assessing PD-L1 expression, we sought determine the potential therapeutic benefit PD-1/PD-L1 inhibitors OCCC. Methods and results The retrospective study included 152 individuals with OCCC between 2019 2022 at Peking Union Medical College Hospital. Paired tumors primary versus recurrent...
Candida albicans (C. albicans), the most common fungal pathogen, has ability to form a biofilm, leading enhanced virulence and antibiotic resistance. Cocultimycin A, novel antifungal isolated from co-culture of two marine fungi, exhibited potent inhibitory effect on planktonic C. cells. This study aimed evaluate anti-biofilm activity cocultimycin A against explore its underlying mechanism. Crystal violet staining showed that remarkably inhibited biofilm formation in dose-dependent manner...
Small cell lung cancer (SCLC) is an aggressive form of that uniquely changes the chromosomal structure, although basis aberrant gene expression in SCLC remains largely unclear. Topologically associated domains (TADs) are structural and functional units human genome. Genetic epigenetic alterations genome can lead to disruption TAD boundaries may cause dysregulation. To understand potential regulatory role this process SCLC, we developed boundary alteration-related identification tumors...
The RNA quality of tissue biobank is crucial for translational research; however, the effects ex vivo ischemia time on integrity and expression genes related to hypoxia, stress, apoptosis autophagy remains elusive. A total 18 carcinoma tissues were stored at room temperature 15 min, 30 1, 2, 4, 8 24 h. purity isolated analyzed. Furthermore, gene mTOR, hypoxia‑inducible factor 1α, phosphatidylinositol 4,5‑bisphosphate 3‑kinase catalytic subunit β isoform (PI3KCB), threonine kinase 1 (AKT1),...
<title>Abstract</title> Background The high mortality and medical costs of sepsis have resulted in a significant consumption resources, improving the diagnosis treatment strategies for disease has always been hot area. Studies indicated that clinical outcomes patients with hyperoxaemia after surgery improved, but they are still limited to observational studies small samples. aim this study is examine suitable range oxygen partial pressure post-surgery its correlation prognosis. Methods We...
<title>Abstract</title> Background Praying mantises, members of the order Mantodea, play important roles in agriculture, medicine, bionics, and entertainment. However, scarcity genomic resources has hindered extensive studies on mantis evolution behaviour. Results Here, we present chromosome-scale reference genomes five species: European (<italic>Mantis religiosa</italic>), Chinese (<italic>Tenodera sinensis</italic>), triangle dead leaf (<italic>Deroplatys truncata</italic>), orchid...
Objectives To investigate the effectiveness and safety of TCZ (tocilizumab) monotherapy for chronic periaortitis (CP) patients at acute active stage. Methods Twelve with definite or possible diagnosis CP were enrolled received intravenous infusions (8 mg/kg) every 4 weeks least 3 months. Clinical features, laboratory imaging findings recorded baseline during follow-up. The primary endpoint was rate partial complete remission after months secondary frequency treatment related adverse events....