A5085815024- Bone Metabolism and Diseases
- Kruppel-like factors research
- Peroxisome Proliferator-Activated Receptors
- Bone health and treatments
- Microbial Natural Products and Biosynthesis
- Long-Term Effects of COVID-19
- Fungal Biology and Applications
- SARS-CoV-2 and COVID-19 Research
- Endoplasmic Reticulum Stress and Disease
- Rheumatoid Arthritis Research and Therapies
- interferon and immune responses
- Lipoproteins and Cardiovascular Health
- Viral Infections and Vectors
- Bone health and osteoporosis research
- Diabetes Treatment and Management
- COVID-19 Clinical Research Studies
- Immune Response and Inflammation
- Influenza Virus Research Studies
- Food Quality and Safety Studies
- IL-33, ST2, and ILC Pathways
- Alcohol Consumption and Health Effects
- Cancer, Lipids, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Marine Sponges and Natural Products
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Tsinghua University
2016
Abstract A recent outbreak of pneumonia in Wuhan, China was found to be caused by a 2019 novel coronavirus (2019-nCoV or SARS-CoV-2 HCoV-19). We previously reported the clinical features 12 patients with 2019-nCoV infections Shenzhen, China. To further understand pathogenesis COVID-19 and find better ways monitor treat disease 2019-nCoV, we measured levels 48 cytokines blood plasma those patients. Thirty-eight out 2019-nCoV-infected were significantly elevated compared healthy individuals....
Violaceotides B–E (1–4), four new cyclic tetrapeptides, along with seven known compounds, were identified from the sponge-associated Aspergillus insulicola IMB18-072 co-cultivated marine-derived Alternaria angustiovoidea IMB20-805. Their structures elucidated by extensive analysis of spectroscopic data, including HRESIMS, 1D and 2D NMR, MS/MS data. The absolute configurations determined advanced Marfey's method. Compounds 2, 3, violaceotide A (5) displayed selective antimicrobial activities...
BACKGROUND: Atherosclerosis is the most common cause of cardiovascular diseases. Clinical studies indicate that loss-of-function ASGR1 (asialoglycoprotein receptor 1) significantly associated with lower plasma cholesterol levels and reduces disease risk. However, effect on atherosclerosis remains incompletely understood; whether inhibition causes liver injury controversial. Here, we comprehensively investigated effects underlying molecular mechanisms deficiency overexpression in mice....
Type 2 diabetes mellitus (T2DM) is a common chronic metabolic disease. Peroxisome proliferator-activated receptors (PPARs) play crucial roles in regulating glucolipid metabolism. Previous studies showed that E17241 could ameliorate atherosclerosis and lower fasting blood glucose levels ApoE
Aims Acute alcohol intoxication (AAI) caused by the intake of excessive is a harmful clinical condition and potentially life threatening. Therefore, there has been increasing attention on development anti-alcoholism products. In this study, we evaluated therapeutic benefits an product (Tengcha–Gegen Plant Solid Beverage, which contains Ampelopsis grossedentata, Pueraria Lobata, Hovenia dulcis Thunb, turmeric) in AAI mouse model. Methods The model was established through gavage. Male Kunming...
The probability of cardiovascular events has been reported lower in rheumatoid arthritis (RA) patients treated with leflunomide.However, the anti-atherosclerotic and protective effects metabolism leflunomide are not explored.In this study, we assessed potential benefits on atherosclerosis revealed underlying mechanism.ApoE -/ -mice were fed a western diet (WD) alone or supplemented (20 mg/kg, oral gavage, once per day) for 12 weeks.Samples aorta, heart, liver, serum, macrophages collected.We...
Abstract The H5N1 avian influenza virus causes severe disease and high mortality, making it a major public health concern worldwide. uses the host cellular machinery for several steps of its life cycle. In this report, we observed overexpression ubiquitin-like protein FAT10 following live infection in BALB/c mice human respiratory epithelial cell lines A549 BEAS-2B. Further experiments demonstrated that increased replication decreased viability infected cells. Total RNA extracted from...
Phenethyl isothiocyanate is widely present in cruciferous vegetables with multiple biological effects. Here we reported the antiatherogenic effects and underlying mechanisms of JC-5411 (Phenethyl formulation) vitro vivo . Luciferase reporter assay showed that increased activity nuclear factor erythroid 2-related 2 (Nrf2) antioxidant response element (ARE). treatment significantly protein expression Nrf2 its downstream target gene hemeoxygenase 1 (HO-1) liver apolipoprotein E deficient (ApoE...
Krüppel-like factor 2 (KLF2) is an atherosclerotic protective transcription that maintains endothelial cell homeostasis through its anti-inflammatory, anti-oxidant, and antithrombotic properties. The aim of this study was to discover KLF2 activators from microbial secondary metabolites explore their potential molecular mechanisms. By using a high-throughput screening model based on promoter luciferase reporter assay, column chromatography, electrospray ionization mass spectrometry (ESI-MS),...
Particulate matter (PM) air pollution poses a significant risk to respiratory health and is especially linked with various infectious diseases such as influenza. Our previous studies have shown that H5N1 virus infection could induce alveolar epithelial A549 cell death by enhancing lysosomal dysfunction. This study aims investigate the mechanisms underlying effects of PM on influenza infections, particular focus dysfunction.Here, we showed nanoparticles silica alumina dysfunction, degradation...