A5027876060- Neurobiology and Insect Physiology Research
- Hearing, Cochlea, Tinnitus, Genetics
- Plant Molecular Biology Research
- Animal Behavior and Reproduction
- Insect and Arachnid Ecology and Behavior
- Circadian rhythm and melatonin
- RNA Research and Splicing
- Image Enhancement Techniques
- melanin and skin pigmentation
- Sleep and Wakefulness Research
- Neural dynamics and brain function
- Connexins and lens biology
- Photoreceptor and optogenetics research
- Visual perception and processing mechanisms
- Biochemical Analysis and Sensing Techniques
- RNA regulation and disease
- Olfactory and Sensory Function Studies
- Plant and animal studies
National Institute on Deafness and Other Communication Disorders
2024
Janelia Research Campus
2019-2022
Helix (United States)
2022
Howard Hughes Medical Institute
2019
University of Chinese Academy of Sciences
2012-2014
Shanghai Institutes for Biological Sciences
2012-2014
Chinese Academy of Sciences
2013-2014
Animals consolidate some, but not all, learning experiences into long-term memory. Across the animal kingdom, sleep has been found to have a beneficial effect on consolidation of recently formed memories storage. However, underlying mechanisms dependent memory are poorly understood. Here, we show that courtship in Drosophila is mediated by reactivation during dopaminergic neurons were earlier involved acquisition. We identify specific fan-shaped body induce after experience and activate for...
Hair cells of the inner ear rely on specialized ribbon synapses to transmit sensory information central nervous system. The molecules required assemble these are not fully understood. We show that Nrxn3, a presynaptic adhesion molecule, is critical for ribbon-synapse assembly in hair cells. In both mouse and zebrafish models, loss Nrxn3 results significantly fewer intact synapses. we demonstrate 60%
Animals retain some but not all experiences in long-term memory (LTM). Sleep supports LTM retention across animal species. It is well established that learning enhance post-learning sleep. However, the underlying mechanisms of how mediates sleep for are clear. Drosophila males display increased amounts after courtship learning. Courtship depends on Mushroom Body (MB) neurons, and mediated by sleep-promoting ventral Fan-Shaped neurons (vFBs). We show regulated two opposing output (MBONs) from...
Although the response properties of most neurons are, to a large extent, determined by presynaptic inputs that they receive, comprehensive functional characterization single neuron remains elusive. Toward this goal, we introduce dual-color calcium imaging approach simultaneously monitors responses postsynaptic together with its axon terminal in vivo. As model system, applied strategy feed-forward connections from projection (PNs) Kenyon cells (KCs) mushroom body Drosophila and functionally...
Abstract Astrocyte‐like glial cells are abundant in the central nervous system of adult D rosophila and exhibit morphology similar to astrocytes mammals. Previous evidence has shown that astrocyte‐like strongly associated with synapses antennal lobe ( AL ), first relay olfactory system, where receptor neurons ORN s) transmit information into projection PN s). However, function glia remains obscure. In this study, using vivo calcium imaging, we found exhibited spontaneous microdomain...
Hair cells of the inner ear and lateral-line system rely on specialized ribbon synapses to transmit sensory information central nervous system. The molecules required assemble these are not fully understood. We show that Nrxn3, a presynaptic adhesion molecule, is critical for ribbon-synapse maturation in hair cells. In both mouse zebrafish models, loss Nrxn3 results significantly fewer intact synapses. initially, nrxn3 mutants have normal pre- post-synapse numbers, but fail pair, leading...
Summary A wide variety of animal species including humans and fruit flies see second-order motion lacking coherent spatiotemporal correlations in luminance. Recent electrophysiological recordings, together with intensive psychophysical studies, are bringing to light the neural underpinnings perception mammals. However, where how higher-order signals processed fly brain is poorly understood. Using rich genetic tools available Drosophila examining optomotor responses several stimuli, we...
Abstract Sensory hair cells of the inner ear utilize specialized ribbon synapses to transmit sensory stimuli central nervous system. This transmission necessitates rapid and sustained neurotransmitter release, which depends on a large pool synaptic vesicles at hair‐cell presynapse. While previous work in neurons has shown that kinesin motor proteins traffic material along microtubules presynapse, mechanisms this process remain unclear. Our study demonstrates protein Kif1a, with an intact...
Sensory hair cells of the inner ear utilize specialized ribbon synapses to transmit sensory stimuli central nervous system. This transmission necessitates rapid and sustained neurotransmitter release, which relies on a large pool synaptic vesicles at hair-cell presynapse. Work in neurons has shown that kinesin motor proteins traffic material along microtubules presynapse, but how new reaches presynapse is not known. We show protein Kif1a an intact microtubule network are necessary enrich...