A5064372540- Pharmacological Effects of Natural Compounds
- Microbial Metabolic Engineering and Bioproduction
- Plant biochemistry and biosynthesis
- Enzyme Catalysis and Immobilization
- Natural product bioactivities and synthesis
- Glycosylation and Glycoproteins Research
- Membrane Separation Technologies
- Enzyme Production and Characterization
- Carbohydrate Chemistry and Synthesis
- Synthesis and characterization of novel inorganic/organometallic compounds
- Biochemical and Molecular Research
- Extraction and Separation Processes
- Turbomachinery Performance and Optimization
- Microbial Natural Products and Biosynthesis
- Metal-Catalyzed Oxygenation Mechanisms
- Organophosphorus compounds synthesis
- Organoboron and organosilicon chemistry
- Chemical Synthesis and Characterization
- Membrane-based Ion Separation Techniques
- Organometallic Complex Synthesis and Catalysis
- Microbial Metabolites in Food Biotechnology
- Phytochemistry and biological activity of medicinal plants
- Advanced Chemical Sensor Technologies
- Chromatography in Natural Products
- Biofuel production and bioconversion
Beijing Institute of Technology
2015-2024
Ministry of Industry and Information Technology
2021-2024
Beijing Technology and Business University
2003-2024
Institute of Soil Science
2024
University of Chinese Academy of Sciences
2024
First Affiliated Hospital of Kunming Medical University
2024
Kunming Medical University
2024
Ningbo University
2024
Ningbo Medical Center Lihuili Hospital
2024
Ministry of Education of the People's Republic of China
2023
S. cerevisiae was genetically reprogrammed to produce ginsenoside Ro with seven exogenous enzymes from five species. This study also paved a good way for the synthesis of other complex glycosides triterpenoids.
Glycyrrhetinic acid 3-O-monoglucuronide (GAMG) and glycyrrhizin (GL) are typical pentacyclic triterpenoid saponins present in licorice roots that exhibit important pharmacological properties. GAMG GL sourced primarily from licorice, namely, "digging extracting acid", which results ecological imbalance environmental pollution. To overcome these issues, it is an eco-friendly sustainable alternative to de novo synthesize Saccharomyces cerevisiae by coupling UDP-glucuronic glycyrrhetinic (GA)...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe structure of a monomeric phosphinoborane: synthesis and x-ray crystal (diphenylphosphino)dimesitylboraneXudong Feng, Marilyn M. Olmstead, Philip P. PowerCite this: Inorg. Chem. 1986, 25, 26, 4615–4616Publication Date (Print):December 1, 1986Publication History Published online1 May 2002Published inissue 1 December 1986https://pubs.acs.org/doi/10.1021/ic00246a002https://doi.org/10.1021/ic00246a002research-articleACS PublicationsRequest reuse...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of the phosphinidene borate complexes [Li(Et2O)2PRB(Mes)2] [Li(12-crown-4)2][RPB(Mes)2].cntdot.THF [R = Ph, C6H11 or Mes (Mes 2,4,6-Me3C6H2)]: first structurally characterized boron-phosphorus double bondsRuth A. Bartlett, Xudong. Feng, Philip P. PowerCite this: J. Am. Chem. Soc. 1986, 108, 21, 6817–6819Publication Date (Print):October 1, 1986Publication History Published online1 May 2002Published inissue 1 October...
The growth and production of microorganisms in bioconversion are often hampered by heat stress. In this study, an intelligent microbial heat-regulating engine (IMHeRE) was developed customized to improve the thermo-robustness Escherichia coli via integration a thermotolerant system quorum-regulating system. At cell level, composed different shock proteins RNA thermometers hierarchically expands optimum temperature sensing changes. community dynamically programs altruistic sacrifice...
Abstract Pentacyclic triterpenoids have wide applications in the pharmaceutical industry. The precise glucosylation at C‐3 OH of pentacyclic mediated by uridine 5'‐diphospho‐glucosyltransferase (UDP‐glucosyltransferase [UGT]) is an important way to produce valuable derivatives with various improved functions. However, most reported UGTs suffer from low regiospecificity toward and COOH groups triterpenoids, which significantly decreases reaction efficiency. Here, two new (UGT73C33 UGT73F24)...
Yeast surface display is an appealing technique for constructing multienzyme cascades. This commonly achieved using a scaffold the ordered arrangement of various enzymes. However, this method typically complicated because use may engender extra metabolic burden on cell host. Here, we established direct yeast codisplay strategy by employing two complementary anchor motifs, Agα1 and Pir1. These motifs allow sequential uridine diphosphate-glycosyltransferase (UGT) sucrose synthase (SUS) Pichia...
Glycosylation is an important method of modifying natural products and usually catalyzed by uridine 5'-diphosphate (UDP)-glycosyltransferase. UDP-β-l-arabinose (UDP-Ara) confers specific functions to such as pentacyclic triterpenoids. However, UDP-arabinosyltransferase with high regioselectivity toward triterpenoids has rarely been reported. In addition, UDP-Ara mainly biosynthesized from UDP-α-d-glucose (UDP-Glc) through several reaction steps, resulting in the cost UDP-Ara. Herein, UGT99D1...