An environmentally friendly electrocatalytic protocol has been developed for dehydrogenative C-H/S-H cross-coupling. This method enabled C-S bond formation under catalyst- and oxidant-free conditions. Under undivided electrolysis conditions, various aryl/heteroaryl thiols electron-rich arenes afforded the bond-formation products in 24-99 % yield. A preliminary mechanistic study indicated that generation of aryl radical cation intermediates is key to success this transformation.

An environmentally friendly electrochemical protocol about cobalt-catalyzed C–H amination of arenes has been developed, which offers a simple way to access synthetically useful arylamines. In divided cells, wide variety and alkylamines are examined afford C–N formation products without using external oxidants, avoids the undesired byproducts exhibits high atom economy. Importantly, reaction can also be extended gram level with moderate efficiency. KIE experiments indicate that bond cleavage...

Sulfur is an essential element because it exists widely in proteins. The disulfide bond important moiety many different types of significant organic molecules. A new approach for oxidant- and catalyst-free S-H/S-H cross-coupling, with hydrogen evolution, to construct unsymmetrical disulfides was developed. Under the conditions undivided cell at room temperature, a series were prepared up 87 % yield from direct coupling aryl mercaptan alkyl mercaptan. Gram-scale synthesis also highlights...

Abstract A ligand‐promoted catalytic [4+2] annulation reaction using indole derivatives and donor‐acceptor (D‐A) cyclobutanes is reported, thus providing an efficient atom‐economical access to versatile cyclohexa‐fused indolines with excellent levels of diastereoselectivity a broad substrate scope. In the presence chiral SaBOX ligand, enantioselectivity was realized up 94 % ee. This novel synthetic method applied as general protocol for total synthesis (±)‐akuammicine formal (±)‐strychnine...

A user-friendly approach is presented to sidestep the venerable Grignard addition unactivated ketones access tertiary alcohols by reversing polarity of disconnection. In this work a ketone instead acts as nucleophile when adding simple olefins accomplish same overall transformation. The scope coupling broad enabled using an electrochemical approach, and reaction scalable, chemoselective, requires no precaution exclude air or water. Multiple applications demonstrate simplifying nature on...

Abstract Radical involved transformations are now considered as extremely important processes in modern organic synthetic chemistry. According to the demand by atom-economic and sustainable chemistry, direct C(sp 3 )–H functionalization through radical oxidative coupling represents an appealing strategy for C–C bond formations. However, selectivity control of reactive intermediates is still a great challenge these transformations. Here we show selective )–H/C(sp)–H cross-coupling unactivated...

Abstract Aqueous organic redox flow batteries (AORFBs) are a promising electrochemical technology for large‐scale energy storage. We report biomimetic, ultra‐stable AORFB utilizing an amino acid functionalized phenazine (AFP). A series of AFPs with various commercial acids at different substituted positions were synthesized and studied. 1,6‐AFPs display much higher stability during cycling when compared to 2,7‐ 1,8‐AFPs. Mechanism investigations reveal that the reduced 1,8‐AFPs tend...

Aqueous V2 O5 -Zn batteries, an alternative chemistry format that is inherently safer to operate than lithium-based illuminates the low-cost deployment of stationary energy storage devices. However, cathode structure collapse caused by H2 O co-insertion in aqueous solution dramatically deteriorates electrochemical performance and hampers operation reliability batteries. The real-time phase tracking density functional theory (DFT) calculation prove high barrier inhibits Zn2+ diffusion into...

Materials with magneto-optic (MO) properties have enabled critical fiber-optic applications and highly sensitive magnetic field sensors. While traditional MO materials are inorganic in nature, new generations of based on organic semiconducting polymers could allow increased versatility for device architectures, manufacturing options, flexible mechanics. However, the origin activity is far from understood. In this paper, we report high observed a chiral helical poly-3-(alkylsulfone)thiophene...

Electrochemical oxidative C-H/S-H cross-coupling has been developed to construct the C-S bond in a highly straightforward and efficient manner. Various enamines (hetero)aryl thiols could be transformed smoothly under undivided electrolytic cell conditions. Moreover, this electrosynthesis strategy not only avoided use of chemical oxidants transition metal catalysts, but also exhibited excellent atom economy.

The unique geometry of screw extruders allows handling very viscous media; thus, they can be used as continuous reactors to conduct polymerization reactions without using any solvents. This is called reactive extrusion polymerization. It an intensified process it maximizes reaction rates upon maximizing the concentrations monomers and initiator/catalyst (if there any). also conducting at higher temperatures, having take measures prevent solvents from evaporating or work under pressure....

Long-lived water-soluble organic radical species have long been desired for applications in bioimaging and aqueous energy storage technologies. In the present work, we report a phenazine cation sodium 3,3'-(phenazine-5,10-diyl)bis(propane-1-sulfonate) (PSPR) with high solubility of 1.4 M stability water. Collaboratively demonstrated by experiments theoretical calculations, PSPR is not prone to undergo dimerization or disproportionation reactions, its appropriate electron density avoids...

An asymmetric intramolecular Cannizzaro reaction of aryl and alkyl glyoxals with alcohols has been realized an unprecedented high level enantioselectivity, on the basis a newly developed congested TOX ligand gradual liberation protocol active from glyoxal monohydrates. Preliminary results suggested mechanism enantioselective addition to contributing most stereoselectivity, other than by dynamic kinetic resolution hemiacetal intermediates.

A new way for C(sp3)-C(sp) cross-coupling with terminal alkynes has been developed by using a multi-metal-catalyzed reaction strategy. Alkyl radicals generated from different approaches are able to couple judicious selection of the catalyst combination. This protocol offers an efficient alternative approach synthesis substituted besides traditional Sonogashira coupling. Mechanistic studies have also carried out clarify role each metal in radical alkynylation processes. The reactions were...

Heterocyclic compounds, especially nitrogen heterocycles, are one of the most important classes compounds in pharmaceutical and agrochemical industries.

Substrate-controlled switchable asymmetric annulations of Morita–Baylis–Hillman carbonates from isatins and α-cyano-α,β-unsaturated ketones catalysed by cinchona-derived tertiary amines, giving tetrahydrofuro[2′,3′:4,5]pyrano[2,3-<italic>b</italic>]indoles or spirooxindoles incorporating a cyclopentene motif, were disclosed.

Abstract Sulfur is an essential element because it exists widely in proteins. The disulfide bond important moiety many different types of significant organic molecules. A new approach for oxidant‐ and catalyst‐free S−H/S−H cross‐coupling, with hydrogen evolution, to construct unsymmetrical disulfides was developed. Under the conditions undivided cell at room temperature, a series were prepared up 87 % yield from direct coupling aryl mercaptan alkyl mercaptan. Gram‐scale synthesis also...

Investigations of magnetism in electronically coupled polyradicals have largely focused on applications photonic and magnetic devices, wherein radical polymers were found to possess molecularly tunable cooperative properties. Radical with nonconjugated insulating backbones been intensively investigated previously; however the integration species into conducting polymer is at an early stage. We report herein 1,3-bisdiphenylene-2-phenylallyl (BDPA)-based conjugated that display ambipolar redox...

Compared with the reported intramolecular electro-oxidative cyclization of alkenyl amines or vinyl anilines for preparation pyrrolidines indolines, intermolecular version is less studied.