A5100774581- Biochemical and Molecular Research
- Cancer Immunotherapy and Biomarkers
- Psoriasis: Treatment and Pathogenesis
- Traditional Chinese Medicine Analysis
- Histone Deacetylase Inhibitors Research
- Blood disorders and treatments
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Gene expression and cancer classification
- Pharmacological Effects of Natural Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal Health and Biochemistry
- Traditional Chinese Medicine Studies
- Radiopharmaceutical Chemistry and Applications
- Cancer Cells and Metastasis
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Signaling Pathways in Disease
- Selenium in Biological Systems
- Circular RNAs in diseases
- Metabolism and Genetic Disorders
- Immune cells in cancer
- Prenatal Substance Exposure Effects
- Fuel Cells and Related Materials
Foshan Hospital of TCM
2022-2025
Guangzhou University of Chinese Medicine
2022-2025
UConn Health
2017-2024
Guizhou Academy of Agricultural Sciences
2014-2024
Affiliated Hospital of Southwest Medical University
2024
Taizhou First People's Hospital
2024
Bureau of Geology and Mineral Exploration and Development of Guizhou Province
2023
Jimei University
2004-2023
Zhengzhou University
2023
Shenyang Pharmaceutical University
2023
Abstract Compelling evidence has demonstrated the potential functions of circular RNAs (circRNAs) in breast cancer (BC) tumorigenesis. Nevertheless, underlying mechanism by which circRNAs regulate BC progression is still unclear. The purpose present research was to investigate novel circRNA circRNF20 (hsa_circ_0087784) and its role BC. CircRNA microarray sequencing revealed that one upregulated transcripts samples. Increased level predicted poor clinical outcome specimens. Functionally,...
During sepsis, acute lung injury (ALI) results from activation of innate immune cells and endothelial by endotoxins, leading to systemic inflammation through proinflammatory cytokine overproduction, oxidative stress, intracellular Ca2+ overload. Despite considerable investigation, the underlying molecular mechanism(s) LPS-induced ALI remain elusive. To determine whether stromal interaction molecule 1–dependent (STIM1-dependent) signaling drives dysfunction in response LPS, we investigated...
Abstract Glioblastoma is an aggressive tumor that associated with distinctive infiltrating microglia/macrophages populations. Previous studies demonstrated chlorogenic acid (5-caffeoylquinic acid, CHA), a phenolic compound low molecular weight, has anti-tumor effect in multiple malignant tumors. In the present study, we focused on macrophage polarization to investigate mechanisms behind anti-glioma response of CHA vitro and vivo . We found treatment increased expression M1 markers induced by...
<h3>Background</h3> The IL-17 family cytokines are potent drivers of colorectal cancer (CRC) development. We and others have shown that mainly signals to tumor cells promote CRC, but the underlying mechanism remains unclear. also dampens Th1-armed anti-tumor immunity, in part by attracting myeloid tumor. Whether controls activity adaptive immune a more direct manner, however, is unknown. <h3>Methods</h3> Using mouse models sporadic or inducible cancers, we ablated IL-17RA whole body...
The neuroprotective effects of Licochalcone A (Lico.A), a flavonoid isolated from the herb licorice, in Parkinson’s disease (PD) have not been elucidated. prominent pathological feature PD is loss dopaminergic neurons. crucial role neuroinflammation induced by activated microglia neurodegeneration has validated. In this study, we explore therapeutic Lico.A lipopolysaccharide (LPS)-induced models vivo and vitro. We find that significantly inhibits LPS-stimulated production pro-inflammatory...
// Ya-Li Gao 1, * , Ming-Yun Zhang Bo Xu 2 Li-Jie Han 1 Shou-Feng Lan Ju Chen Yu-Jin Dong 2, and Li-Li Cao Department of Radiotherapy, Cangzhou Central Hospital, Hebei 061001, China Zibo Shandong 255020, These authors have contributed equally to this work Correspondence to: Dong, email: dongyujin_mili@yeah.net Cao, caolili200908@yeah.net Keywords: cervical cancer, circular RNA, hsa_circ_0018289, miR-497, tumorigenesis Received: June 30, 2017 Accepted: July...
Rujifang (RJF) constitutes a traditional Chinese medicinal compound extensively employed in the management of triple-negative breast cancer (TNBC). However, information regarding its potential active ingredients, antitumor effects, safety, and mechanism action remains unreported. To investigate efficacy safety RJF context TNBC. We ultra high-performance liquid chromatography-electrospray four-pole time-of-flight mass spectrometry technique (UPLC/Q-TOF-MS/MS) to scrutinize chemical...
Neuregulins are a multi-isoform family of growth factors that activate members the erbB receptor tyrosine kinases. The membrane-anchored isoforms contain receptor-activating ligand in their extracellular domain, single membrane-spanning region, and long cytoplasmic tail. To evaluate potential biological role intracellular domain neuregulin isoforms, we used domain-specific gene disruption approach to produce mouse line which only region encoding almost entire was disrupted. Consistent with...
Background and Purpose: The aim of this study was to explore the effect half a year evolocumab plus moderate-intensity statin treatment on carotid intraplaque neovascularization (IPN) blood lipid levels. Methods: A total 31 patients with 33 plaques who received were included. Blood levels, B-mode ultrasound contrast-enhanced ultrasonography (CEUS) at baseline after therapy collected. area under curve (AUC) reflected amount acoustic developer entering plaque or lumen within 180 s measurement...
Paojiao, a typical Chinese traditional fermented pepper, is favored by consumers for its unique flavor profile. Microorganisms, organic acids, amino and volatile compounds are the primary constituents influencing development of paojiao's flavor. To elucidate key core microorganisms Qicaipaojiao (QCJ), this study conducted comprehensive analysis changes in taste substances (organic acids acids) during QCJ fermentation. Key were identified using threshold aroma value odor activity determined...
Cystic fibrosis (CF) is an inherited life-threatening disease accompanied by repeated lung infections and multiorgan inflammation that affects tens of thousands people worldwide. The causative gene, cystic transmembrane conductance regulator (CFTR), mutated in CF patients. CFTR functions epithelial cells have traditionally been thought to cause the symptoms. Recent work has shown additional defect: monocytes from patients show a deficiency integrin activation adhesion. Because play critical...
Abstract Activation of Gasdermin D (GSDMD) results in its cleavage, oligomerization, and subsequent formation plasma membrane pores, leading to a form inflammatory cell death denoted as pyroptosis. The roles GSDMD inflammation immune responses infection are well documented. However, whether also plays role sporadic cancer development, especially that the gut epithelium, remains unknown. Here, we show is activated colorectal tumors both human mouse origins. Ablation model resulted reduced...
Background Interleukin-17 (IL-17) family cytokines play critical roles in inflammation and pathogen resistance. Inflammation the central nervous system, denoted as neuroinflammation, promotes onset progression of Alzheimer's disease (AD). Previous studies showed that IL-17A neutralizing antibody treatment alleviated Amyloid β (Aβ) burden rodent models AD, while overexpression mouse lateral ventricles rescued part AD pathology. However, involvement IL-17 its mechanism action remain largely...