A5051118986- Orthopedic Surgery and Rehabilitation
- Bone Metabolism and Diseases
- Bone fractures and treatments
- Elbow and Forearm Trauma Treatment
- Sarcoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Hip disorders and treatments
- Inflammasome and immune disorders
- Orthopaedic implants and arthroplasty
- Circular RNAs in diseases
- Natural product bioactivities and synthesis
- Ferroptosis and cancer prognosis
- Curcumin's Biomedical Applications
- Phytochemistry and Biological Activities
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Bone health and osteoporosis research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hip and Femur Fractures
- Bone health and treatments
- Congenital heart defects research
- Kruppel-like factors research
- Plant Toxicity and Pharmacological Properties
- Genomics, phytochemicals, and oxidative stress
- TGF-β signaling in diseases
- Connective tissue disorders research
Shandong University of Traditional Chinese Medicine
2023-2025
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2015-2025
Background Osteosarcoma (OS) is one of the most common primary malignant bone tumors, primarily originating from mesenchymal tissue. It notorious for its high invasiveness, disability rate, mortality and poor prognosis. In metastatic destruction can promote cancer progression, which closely related to osteoclast activation imbalance between osteoblasts osteoclasts. A large number studies confirmed that osteoclasts are an important part OS, play active role in destroying homeostasis promoting...
Curcumin, an antitumor agent, has been shown to inhibit cell growth and metastasis in osteosarcoma. However, there is no evidence of curcumin its regulation ferroptosis nuclear factor E2–related 2 (Nrf2)/glutathione peroxidase 4 (GPX4) signaling pathways This study aimed investigate the effects on osteosarcoma both vitro vivo. To explore mechanisms osteosarcoma, cells (MNNG/HOS MG-63) xenograft mice models were established. Cell viability, apoptosis rate, cycle distribution, migration,...
Three-dimensional computed tomography (3D CT) has been regarded by some investigators as the gold standard for measurements of femoral neck anteversion angle (FNA) in developmental dysplasia hip (DDH), although a simple and reliable imaging method using non-ionizing technique is needed.To determine consistency between FNA DDH 3D CT magnetic resonance (MRI) to estimate precision, reliability, reproducibility MRI measurement assess whether could replace CT.3D were used measure 22 patients,...
Verbascoside (VB), which is found in many medicinal plant families, exhibits biological activities various diseases. However, its effects on varicocele (VCL)-induced damage remain unknown.To investigate the and mechanism of VB experimental rats with damage.Sixty sexually mature male Sprague-Dawley (SD) were divided into six groups (n = 10): control, control-sham, VCL-vehicle (normal saline), VCL + (50, 100, 200 mg/kg/day, intraperitoneally). After 4 weeks treatment, all animals sacrificed,...
Abstract Ankle injuries are the most common pediatric injury. epiphyseal fractures also in children, but isolated distal fibular of fibula clinically rare. We describe one unusual case an adolescent with a completely displaced Salter-Harris type II fracture. The attempt closed reduction failed, and patient required open internal fixation. localized periosteum superior peroneal retinaculum were avulsed from metaphysis, tendons underneath exposed no obvious subluxation. To best our knowledge,...
Objects This study intends to explore the possible mechanisms of curcumin’s action after knee osteoarthritis. Methods Chondrocytes alone were used mimic cellular inflammatory response with interleukin IL-1β. Overexpressing TRPM2 chondrocytes constructed using cell transfection technique for mechanism verification. The proliferation was assessed by CCK8 assay, ROS level detected flow cytometry, factor content ELISA kit, and molecules pyroptosis-related signaling pathway western blot...
Osteogenesis imperfecta (OI) is a group of genetic disorders characterized mainly by fractures and bone deformities. It has been established that gene mutations, particularly those in COL1A1 COL1A2, account for most phenotypes. Here, we generated an induced pluripotent stem cells (iPSCs) line named SMBCi014-A using urine (UCs) derived from 15-year-old female OI type I patient who carried the frame-shift mutation (exon35:c.2450delC:p.P817fs). The had family history mild blue sclera....