A5101999412- Blood properties and coagulation
- Venous Thromboembolism Diagnosis and Management
- Clinical Laboratory Practices and Quality Control
- Cancer-related molecular mechanisms research
- Renal function and acid-base balance
- Blood Coagulation and Thrombosis Mechanisms
- Ruminant Nutrition and Digestive Physiology
- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- RNA modifications and cancer
- Reliability and Agreement in Measurement
- Reproductive Physiology in Livestock
- Oral Health Pathology and Treatment
- Electrochemical Analysis and Applications
- Salivary Gland Disorders and Functions
- Microbial Metabolism and Applications
- Cancer Treatment and Pharmacology
- Pesticide Residue Analysis and Safety
- Circular RNAs in diseases
- Breast Cancer Treatment Studies
- Biochemical and Structural Characterization
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolomics and Mass Spectrometry Studies
- Potassium and Related Disorders
Chinese PLA General Hospital
2025
Zhejiang University
2024
Capital Medical University
2023-2024
Beijing Tian Tan Hospital
2023-2024
Beijing Hospital
2017-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2021
Peking University
2021
National Center for Clinical Laboratories
2017-2018
Jilin University
2011
Brain Hospital of Jilin
2011
Estimated glucose disposal rate (eGDR) is considered as a reliable alternative indicator of insulin resistance. However, the relationship between eGDR levels and mortality among individuals with cardiometabolic syndrome (CMS), well within different metabolic states in this population, remains unclear. We conducted cohort study on 9928 CMS participants from National Health Nutrition Examination Survey (NHANES) database 1999 to 2018. The population was evaluated using multivariable Cox...
Abstract Background : Serum calcium level is an important clinical index that reflects pathophysiological states. However, detection accuracy in laboratory tests not ideal; as such, a high method needed. Methods: We developed reference for measuring serum levels by isotope dilution inductively coupled plasma mass spectrometry (ID ICP-MS), using 42 Ca the enriched isotope. was digested with 69% ultrapure nitric acid and diluted to suitable concentration. The 44 Ca/ ratio detected H 2 mode;...
Abstract Background: Potassium is an important serum ion that frequently assayed in clinical laboratories. Quality assurance requires reference methods; thus, the establishment of a candidate method for potassium measurements important. Methods: An inductively coupled plasma mass spectrometry (ICP-MS) was developed. Serum samples were gravimetrically spiked with aluminum internal standard, digested 69% ultrapure nitric acid, and diluted to required concentration. The Results: correlation...
Staphylococcus epidermidis is one of the most commonly isolated species from human skin and second leading cause bloodstream infections. Here, we performed a large-scale comparative study without any pre-assigned reference to identify genomic determinants associated with diversity adaptation S. strains various environments. Pan-genome was open 435 core proteins had pan-genome size 8,034 proteins. Genome-wide phylogenetic tree showed high heterogeneity suggested that routine whole genome...
Abstract Background The commutability of electrolyte trueness verification materials (ETVs) and commercial general chemistry (GCs) was evaluated to investigate their suitability for use in an external quality assessment (EQA) program serum sodium potassium measurements. Methods Eighty fresh individual human samples (40 measurements 40 measurements), six ETVs three GCs were analyzed by five routine methods (validated methods) inductively coupled plasma mass spectrometry reference (comparative...
Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by symptoms such as dry mouth, eyes, and other systematic symptoms. Due to the hyposalivation experienced pSS patients, oral dysbacteriosis often occurs. A common complication of Candida infection. In this article, authors describe methods that can effectively diagnose infection identify strains using saliva, mucosal swabs, or mouthwash from patients. The Sabouraud's Dextrose Agar (SDA), hyphal formation assay, potassium...
Previous research has demonstrated that in pregnant mice deficient l-methionine (Met), the mixture of dipeptide l-methionyl-l-methionine (Met-Met) with Met was more effective than alone promoting mammogenesis and lactogenesis. This study aimed to investigate role a novel long noncoding RNA (lncRNA), named mammary gland proliferation-associated lncRNA (MGPNCR), these processes. Transcriptomic analysis tissues from Met-deficient mice, supplemented either Met-Met/Met or alone, revealed...
Although low-protein diets can improve the nitrogen utilization efficiency and alleviate economic pressures in ruminants, they may also negatively impact dairy performance. Rumen-protected lysine (RPL) supplementation health status growth performance of ruminants without compromising feed intake. In this study, a total thirty-three multiparous goats late-lactation period were randomly divided into three groups that separately fed control diet (namely protein-adequacy group),...
Current laboratory examinations for hypercoagulable diseases focus on the biomarker content of activated coagulation cascade and fibrinolytic system. Direct detection physiologically important protease activities in blood remains a challenge. This study aims to develop general approach that enables determination crucial factors plasmin blood. assay is based proteolytic activation an engineered zymogen l-phenylalanine oxidase (proPAO), which specific cleavage sites were between inhibitory...
Abstract Objective: The aim of this study is to investigate EGFR expression in Triple Negative Breast Cancer (TNBC), and find the relationship between overexpression prognosis TNBC, further clarify significance TNBC provide valuable information for therapy. Methods: 42 triple ***negandection ***ssitive breast cancer patients(studying group) 40 HER2(3+) patients(controling who underwent surgery from January 2000 December 2005 were analyzed. 82 cases paraffin-embedded specimens detected by...
Objectives To analyze the differences in laboratory data between patients with myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD), multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Methods The study included 26 MOGAD who visited Beijing Tiantan Hospital from 2018 to 2021. MS NMOSD clinic during same period were selected as controls. Relevant indicators compared group MS/NMOSD groups, diagnostic performance of meaningful markers was...
Chloride is the main anion in human body. A simple and accurate method for serum chloride measurement was developed using ion chromatography (IC) China.In measurement, samples were diluted 500 times with water, filtered injected into column. mixed eluent (2 mmol/L CO32- + 12 OH-) used peak area signal collected. Five calibrators made from Standard Reference Material (SRM) 919b bracketing method. The IC applied as comparative six selective electrode (ISE) systems evaluated 60 individual...
Abstract Background While surgical reduction with adjuvant chemotherapy is the traditional treatment for high-grade serous ovarian cancer (HGSOC), neoadjuvant (NACT) has increasingly been applied. This work aims to investigate expression profiles before and after NACT, explore changes in tumor microenvironment, expand current treatments, design a combination of options patients. Methods We downloaded 326 pre-NACT RNA sequencing data 37 matched pre- post-NACT samples from The Cancer Genome...