A5047090305- Nutrition and Health in Aging
- Pancreatic and Hepatic Oncology Research
- Frailty in Older Adults
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ubiquitin and proteasome pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Clinical Nutrition and Gastroenterology
- Esophageal and GI Pathology
- RNA modifications and cancer
- Enhanced Recovery After Surgery
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Sepsis Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Digestive system and related health
- Radiomics and Machine Learning in Medical Imaging
- Gut microbiota and health
- Gallbladder and Bile Duct Disorders
- Hepatitis B Virus Studies
- Hernia repair and management
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Qinghai University Affiliated Hospital
2022-2024
Beijing Hospital
2013-2023
Academia Sinica
2022
Second Military Medical University
2022
Academy of Medical Sciences
2022
North China University of Science and Technology
2022
Eastern Hepatobiliary Surgery Hospital
2022
Peking University
2014
Peking University People's Hospital
2014
Biopiezoelectric materials have good biocompatibility and excellent piezoelectric properties, they can generate local currents in vivo to restore the physiological electrical microenvironment of defect promote bone regeneration. Previous studies guided regeneration membranes rarely addressed point restoring it, so this study prepared a Barium titanate/Polylactic acid (BT/PLA) composite membrane investigated its bone-formation, with view providing an experimental basis for clinical tissue...
Abstract Cholesterol gallstones (CGS) still lack effective noninvasive treatment. The etiology of experimentally proven cholesterol stones remains underexplored. This cross‐sectional study aims to comprehensively evaluate potential biomarkers in patients with and assess the effects microbiome‐targeted interventions mice. Microbiome taxonomic profiling was conducted on 191 samples via V3−V4 16S rRNA sequencing. Next, 60 (30 age‐ sex‐matched CGS 30 controls) were selected for metagenomic...
The objective of this study was to assess nutritional risk and status Chinese hospitalized patients at admission discharge relations with clinical outcomes.A prospective, nationwide, multicenter conducted from June September 2014 in 34 large hospitals 18 cities China. Patients ≥ years a hospital stay 7-30 days were recruited. Anthropometric laboratory indicators, screening, assessment by Nutritional Risk Screening 2002 (NRS 2002) subjective global (SGA) performed within 24 hours discharge....
The controlling nutritional status (CONUT) score assesses and is associated with short- long-term prognoses in some diseases, but the significance of CONUT for prediction in-hospital mortality older adults unknown. purpose was to determine importance mortality, short-term complications, length hospital stay, costs adults. Our retrospective cohort study analyzed data from 11,795 adult patients two multicenter studies. We performed receiver operating characteristic curve analysis using as...
Background Older patients are at an increased risk of malnutrition due to many factors related poor clinical outcomes. Objective This study aims develop assisted diagnosis model using machine learning (ML) for identifying older with and providing the focus individualized treatment. Methods We reanalyzed a multicenter, observational cohort including 2660 patients. Baseline was defined global leadership initiative on (GLIM) criteria, population randomly divided into derivation group...
Abstract Background The coronavirus disease 2019 (COVID-19) has caused a global pandemic, resulting in considerable mortality. risk factors, clinical treatments, especially comprehensive models for COVID-19 death are urgently warranted. Methods In this retrospective study, 281 non-survivors and 712 survivors with propensity score matching by age, sex, comorbidities were enrolled from January 13, 2020 to March 31, 2020. Results Higher SOFA, qSOFA, APACHE II SIRS scores, hypoxia, elevated...
To compare the association of geriatric nutritional risk index (GNRI) and controlling status (CONUT) scores with malnutrition, to study their clinical outcomes in older adult cancer patients.
DNA methylation on N6-adenine (6mA) has recently been found to be a potential epigenetic marker in prokaryotes and eukaryotes. However, its distribution patterns functions human tumorigenesis remain largely unknown. Here, we reported global profiling of 6mA sites the genome hepatocellular carcinoma at single-nucleotide resolution using Nanopore sequencing. was widely distributed throughout genome. The were related porphyrin chlorophyll metabolism autosomes oxidative phosphorylation ATP...
DNA methylation is a widespread epigenetic signal in human genome. With Nanopore technology, differential modifications including 5-methylcytosine (5mC) and 6-methyladenine (6mA) can be identified. 5mC the most important modification mammals, although 6mA may also function growth development as well pathogenesis. While role of at CpG islands promoter regions associated with transcriptional regulation has been studied, but relationship between transcription still unclear. Thus, we collected...
To evaluate the effect of oral nutritional supplementation (ONS) on postdischarge status and quality life (QoL) gastrointestinal cancer patients after surgery.A multi-center study was conducted who received surgical treatment from 2013-2015. All were screened using Nutrition Risk Screening 2002 (NRS 2002) to assess risk. Patients with risk randomized into two groups: in group (n=55) given dietary guidance ONS, control (n=59) only guidance. Anthropometric measurements, nutrition-related...
The integration of HBV DNA into the human genome can disrupt its structure in hepatocellular carcinoma (HCC), but complexity genomic remains elusive. Here we applied long-read sequencing to precisely elucidate pattern genome. library was sequenced using on GridION and PacBio Sequel II, respectively. mRNA were next-generation Illumina NextSeq. BLAST (Basic Local Alignment Search Tool) local scripts used analyze patterns. We established an analytical strategy based sequences, analyzed A total...
The association between vitamin D status and inflammation remains unclear in hospitalized patients.
Abstract Background Due to the diversity of immune repertoire (IR), reconstructing full-length IR using traditional short-read sequencing has proven challenging. Methods A (FLIRseq) work flow was developed with linear rolling circle amplification and nanopore sequencing. Its accuracy quantification ability were verified by plasmid mixtures commercial B-cell receptor/T-cell receptor (BCR/TCR-seq) based on short reads. IRs in tissues peripheral blood from 8 patients acute lymphoblastic...
Hepatic ectopic pregnancies are extremely rare and can be associated with excessive maternal morbidity mortality.1 Given the rarity of such a form pregnancy potential mortality, early diagnosis appropriate treatment is essential. We present unique case an 10-week-old fetus implanted on liver, which was treated successfully by hepatic resection. A 31-year-old patient (gravida 3, para 2, aborta 1) presented 10 weeks amenorrhea elevated blood human chorionic gonadotropin (hCG) level 95 700...
Abstract Background: Hepatocellular carcinoma (HCC) accounts for up to 90% of all primary hepatic malignancies; it is the sixth most common cancer and second cause mortality worldwide. Numerous studies have shown that hepatitis B virus its products, HBV integration, mutation can induce HCC. However, molecular mechanisms underpinning regulation HCC induced by remain unclear. Methods: We downloaded 2 gene expression profiling datasets, HBV, from omnibus (GEO) database. Differentially expressed...
Abstract Based on the expert consensus parenteral and enteral nutrition support for geriatric patients in China 2013, domestic multidisciplinary experts were gathered to summarize new evidence field of elderly nutritional at home abroad. The 2013 was comprehensively updated upgraded a guideline by referring World Health Organization (WHO) guidelines Grading Recommendations Assessment, Development, Evaluation system grading evidence. These divided into two parts: general conditions common...
The prognostic performance of four lymph node classifications, the 8th American Joint Committee on Cancer (AJCC) Tumor Node Metastasis (TNM) N stage, ratio (LNR), log odds positive nodes (LODDS), and examined (ELN) in early-onset pancreatic cancer (EOPC) remains unclear.The Surveillance, Epidemiology, End Results (SEER) database was searched for patients with EOPC from 2004 to 2016. 1048 were randomly divided into training (n = 733) validation sets 315). predictive abilities staging systems...
Staphylococcus epidermidis is one of the most commonly isolated species from human skin and second leading cause bloodstream infections. Here, we performed a large-scale comparative study without any pre-assigned reference to identify genomic determinants associated with diversity adaptation S. strains various environments. Pan-genome was open 435 core proteins had pan-genome size 8,034 proteins. Genome-wide phylogenetic tree showed high heterogeneity suggested that routine whole genome...
Objective To investigate the effect of oral nutritional supplementation on status and quality life in patients with gastric cancer after operation. Methods In this prospective, single blind, randomized, controlled clinical study, 25 postoperative received neoadjuvant chemotherapy outpatient clinic were enrolled. All dietary guidance. In intervention group, addition to standard diet, supplements 2 090 kJ/d Intacted Protein Enteral Nutrition Powder added, which lasted 90 days. The...