A5028656879- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Advanced Biosensing Techniques and Applications
- Medical Imaging and Pathology Studies
- Wound Healing and Treatments
- Pressure Ulcer Prevention and Management
- Blood transfusion and management
- Blood groups and transfusion
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Advancements in Transdermal Drug Delivery
- Lymphoma Diagnosis and Treatment
- Periodontal Regeneration and Treatments
- Endometrial and Cervical Cancer Treatments
- Erythrocyte Function and Pathophysiology
- Electrospun Nanofibers in Biomedical Applications
- Balance, Gait, and Falls Prevention
- Parkinson's Disease Mechanisms and Treatments
- Platelet Disorders and Treatments
- Complementary and Alternative Medicine Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Tissue Engineering and Regenerative Medicine
- Cerebral Palsy and Movement Disorders
Chenzhou First People's Hospital
2021-2024
Southern Medical University
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Minzu University of China
2022
Hebei General Hospital
2018
Due to overactive inflammation and hindered angiogenesis, self-healing of diabetic wounds (DW) remains challenging in the clinic. Platelet-derived exosomes (PLT-Exos), a novel exosome capable anti-inflammation pro-angiogenesis, show great potential DW treatment. However, previous administration into skin is topical daub or intradermal injection, which cannot intradermally deliver PLT-Exos dermis layer, thus impeding its long-term efficacy pro-angiogenesis. Herein, dissolvable...
Abstract Background Emerging studies have reported the contribution of cholesterol to hepatocellular carcinoma (HCC) progression. However, specific role and mechanism metabolism on spontaneous progressive HCC development from point view ferroptosis are still worth exploring. The present study aimed reveal a novel metabolism-related in cells. Methods Two microarray datasets (GSE25097, GSE22058) related were downloaded Gene Expression Omnibus (GEO) datasets. Metabolomics analysis was performed...
The management of diabetic wounds is a therapeutic challenge in clinical settings. Current tissue engineering strategies for wound healing are insufficient, owing to the lack an appropriate scaffold that can load large number stem cells and induce interaction form granulation tissue. Herein we fabricated book-shaped decellularized dermal matrix (BDDM), which shows high resemblance native terms its histology, microstructure, ingredients, non-cytotoxic low-immunogenic, allows adipose-derived...
This study explored the effects of Health Qigong exercise on lower limb motor function in patients with Parkinson's disease (PD).A total 40 PD were recruited and randomly allocated into experimental group control group. The completed an intervention over 12 weeks, while did not perform any regular physical activity. Data relating to gait, lower-limb joint range motion, Timed Up Go, as well scores for scale from Unified Comprehensive Rating Scale III (UPCRS III) before after collected...
Primary endometrial squamous cell carcinoma is an extremely rare tumor that tends to occur in postmenopausal women. We report on a 33-year-old woman who presented with history of irregular vaginal bleeding for more than 2 years, and mass 1 month. Biopsy the revealed invasive poorly differentiated carcinoma. The patient underwent radical hysterectomy, bilateral salpingo-oophorectomy, omentectomy, pelvic lymph node dissection, peritoneal sampling resection. On basis her medical history,...
Objective: This study explored the effects of Health Qigong exercise on depression and anxiety in patients with Parkinson’s disease (PD). Methods: A total 42 volunteers who met inclusion criteria were recruited randomly allocated into experimental group control group. The carried out 60-minute sessions five times a week for 12 weeks while did not perform any regular physical exercise. Data cognitive impairment, psychomotor retardation, somatic anxiety, weight loss sleep disorders, sum score...
Abstract Background and objectives Haemovigilance involves surveillance of the whole chain blood transfusion with aim identifying adverse events errors improving outcomes for patients. The Chinese Network, founded in August 2017, has witnessed a rapid development last three years. Materials methods Based on 1,022 cases 2019, we analysed reactions (ARs) by component, clinical outcome severity demography recipients an effort to publish first annual haemovigilance report. Results AR rate...
With improved cancer survivorship, non-cancer events, especially heart disease (HD), have become the underlying cause of death in patients, but risk HD mortality sarcoma patients remains poorly characterized. Therefore, our purpose was to: (1) identify at highest fatal compared with general population, (2) and characteristics associated a higher death, (3) determine if chemotherapy increased patients.From 1975 to 2016, we identified diagnosed bone soft tissue from Surveillance, Epidemiology,...
Autoantibodies hold promise for diagnosing lung cancer. However, their effectiveness in early-stage detection needs improvement. We investigated novel IgG and IgM autoantibodies of adenocarcinoma (Early-LUAD) across three independent cohorts 1246 individuals. A multi-step approach, including Human proteome microarray (HuProtTM) discovery, focused array verification, ELISA validation, was conducted on 634 individuals with Early-LUAD (stage 0-I), 280 benign disease (BLD), 332 normal healthy...
Abstract Background: Early diagnosis is critical to lung adenocarcinoma patients’ survival but faces inadequacies in convenient early detection. Methods: We applied a comprehensive microarray of 130,000 peptides detect “autoantibody signature” that autoantibodies binding mimotopes for detection stage 0–I LUAD. Plasma samples were collected from 147 early-stage (Early-LUAD), 108 benign disease (BLD), and 122 normal healthy controls (NHC). Clinical characteristics, low-dose CT (LDCT),...
<p>Corresponding abbreviated number for differential peptides probes in correlation plot.</p>
<p>Random forest model and GO enrichment. a, Schematic plot of random forest; b, terms enriched by the matched proteins differential peptide probes.</p>
<p>Figure S4. Autoantibodies differentially expressed in plasma samples from patients with Early-LUAD versus BLD. Each boxplot represents an individual peptide signature the two sample sets.</p>
<p>Reproducibility of peptides microarray. a, Heatmap spearman correlation 47 samples tested with 3 technical repeats within one batch. b. 6 repeatedly across batches.</p>
<p>Corresponding signal of previous reported autoantibodies for early lung cancer detection were evaluated in our study cohort with both HuProtTM protein microarray (detail data not shown) and peptide array. All peptides aligned to 10 proteins using blastp method, 246 mapped under the set e-value 1 identity 90. Accumulated was as autoantibody corresponding antigen protein. Nine had effective testing value HuprotTM. a.t test P signals Early-LUAD versus NHC from array respectively. Two 2...
<p>Figure S5. Correlation between differential autoantibody signatures from Early-LUAD versus BLD and blood routine test. Some of the 143 positively correlated with RDW.CV.</p>
<div>AbstractBackground:<p>Early diagnosis is critical to lung adenocarcinoma patients’ survival but faces inadequacies in convenient early detection.</p>Methods:<p>We applied a comprehensive microarray of 130,000 peptides detect “autoantibody signature” that autoantibodies binding mimotopes for detection stage 0–I LUAD. Plasma samples were collected from 147 early-stage (Early-LUAD), 108 benign disease (BLD), and 122 normal healthy controls (NHC). Clinical...
<div>AbstractBackground:<p>Early diagnosis is critical to lung adenocarcinoma patients’ survival but faces inadequacies in convenient early detection.</p>Methods:<p>We applied a comprehensive microarray of 130,000 peptides detect “autoantibody signature” that autoantibodies binding mimotopes for detection stage 0–I LUAD. Plasma samples were collected from 147 early-stage (Early-LUAD), 108 benign disease (BLD), and 122 normal healthy controls (NHC). Clinical...
<p>Random forest model and GO enrichment. a, Schematic plot of random forest; b, terms enriched by the matched proteins differential peptide probes.</p>
<p>Corresponding abbreviated number for differential peptides probes in correlation plot.</p>
<p>Comparisons of positive rate between differential autoantibody signatures and tumor biomarkers in Early-LUAD.</p>
<p>Figure S4. Autoantibodies differentially expressed in plasma samples from patients with Early-LUAD versus BLD. Each boxplot represents an individual peptide signature the two sample sets.</p>
<p>Reproducibility of peptides microarray. a, Heatmap spearman correlation 47 samples tested with 3 technical repeats within one batch. b. 6 repeatedly across batches.</p>