A5062116378- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Bone Metabolism and Diseases
- Bone health and treatments
- Estrogen and related hormone effects
- Acupuncture Treatment Research Studies
- Digestive system and related health
- Connective tissue disorders research
- Bone health and osteoporosis research
- Kruppel-like factors research
- Allergic Rhinitis and Sensitization
- Hippo pathway signaling and YAP/TAZ
- Cancer Cells and Metastasis
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Pancreatic and Hepatic Oncology Research
- Ubiquitin and proteasome pathways
- Sirtuins and Resveratrol in Medicine
- dental development and anomalies
- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Epigenetics and DNA Methylation
- High Entropy Alloys Studies
- Nanoparticle-Based Drug Delivery
- Genomics, phytochemicals, and oxidative stress
Civil Aviation University of China
2024
Xinjiang University
2024
Van Andel Institute
2013-2023
University of Electronic Science and Technology of China
2023
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2014-2021
Hunan Normal University
2020-2021
Hunan Provincial People's Hospital
2020-2021
Chengdu Organic Chemicals (China)
2019
University of California Davis Medical Center
2013-2017
Tianjin University of Technology
2015
Wnt/β-catenin signaling supports intestinal homeostasis by regulating proliferation in the crypt. Multiple Wnts are expressed Paneth cells as well other epithelial and stromal cells. Ex vivo, secreted can support stem when Wnt is enhanced with supplemental R-Spondin 1 (RSPO1). However, source of cell niche less clear. Genetic ablation Porcn, an endoplasmic reticulum resident O-acyltransferase that essential for secretion activity all vertebrate Wnts, confirmed role ex vivo culture....
Recent genome-wide association studies of individuals Asian and European descent have found that SNPs located within the genomic region (1p31.3) encoding Wntless (Wls)/Gpr177 protein are associated significantly with reduced bone mineral density. Wls / Gpr177 is a newly identified chaperone specifically escorts Wnt ligands for secretion. Given strong functional between signaling pathways development homeostasis, we generated osteoblast-specific Wls-deficient ( Ocn-Cre;Wls-flox ) mice....
The ability of Wnt ligands to initiate a signaling cascade that results in cytoplasmic stabilization of, and nuclear localization β-catenin underlies their regulate progenitor cell differentiation. In this review, we will summarize the current knowledge mechanisms underlying Wnt/β-catenin how pathway regulates normal differentiation stem cells intestine, mammary gland, prostate. We also discuss dysregulation is associated with putative cancer potential therapeutic implications regulating signaling.
Microbe-derived butyrate plays an important role in the gut health of young mammals during weaning stage. A greater understanding how regulates intestinal development is necessary for overcoming post-weaning diarrheal diseases. We aimed to investigate whether jejunal microbial metabolite modulates apoptosis/proliferation balance and immune response piglets period first 3 weeks life. On one hand, week post-weaning, relative abundances dominant bacterial families Erysipelotrichaceae (P < 0.01)...
Low-density lipoprotein receptor-related proteins 5 and 6 (Lrp5 Lrp6) are co-receptors of Wnt ligands play important roles in Wnt/β-catenin signal transduction. Mice homozygous for a germline deletion Lrp6 die at birth with several associated defects, while Lrp5-deficient mice viable. Here, we conditionally deleted Lrp5 and/or the mouse gut ((gut-/-)) by crossing carrying floxed alleles to strain expressing Cre recombinase from villin promoter (villin-Cre). The changes morphology,...
ABSTRACT Odontoblasts, cementoblasts, ameloblasts, and osteoblasts all form mineralized tissues in the craniofacial complex, these cell types exhibit active Wnt signaling during postnatal life. We set out to understand functions of this signaling, by evaluating phenotypes mice which essential chaperone protein, Wntless was eliminated. The deletion Wls restricted cells expressing Osteocalcin (OCN), addition includes odontoblasts, ameloblasts. Dentin, cementum, enamel, bone formed...
In the present study, effects of total flavonoids Rhizoma Drynariae (TFRD) and calcium carbonate (CaCO<sub>3</sub>) on osteoporosis (OP) were assessed in a rat model OP. For this purpose, 36 Sprague‑Dawley rats, aged 3 months, randomly divided into group undergoing sham surgery (sham‑operated group), (OP CaCO<sub>3</sub> + TFRD combined with group) N‑acetyl cysteine NAC group). The OP was established by bilateral ovariectomy. changes bone mineral density (BMD), volume parameters...
Abstract Nasopharyngeal carcinoma (NPC) is a common malignant tumor in South China. It has been reported that overexpression of antiapoptotic Bcl‐2 family proteins NPC caused the lack long‐term efficacy conventional therapies. Apogossypolone (ApoG2), novel small‐molecule inhibitor proteins, discovered as optimized derivative gossypol. In this study, we found cells, ApoG2 totally blocked function without affecting expression levels these proteins. selectively inhibited proliferation 3 cell...
This study investigates the fatigue behavior of off-axis carbon fiber reinforced polymer (CFRP) composites under varying stress levels, with a focus on both tensile-tensile and compressive-compressive loading modes. We conduct comprehensive analysis energy dissipation stiffness across various conditions, highlighting critical role deflection effects in recovery properties. Utilizing digital image correlation (DIC) technology, we identify commonalities distinctions crack propagation pathways...