A5075688737- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Heart Failure Treatment and Management
- Cancer Immunotherapy and Biomarkers
- Cutaneous lymphoproliferative disorders research
- Histone Deacetylase Inhibitors Research
- Space Exploration and Technology
- Viral-associated cancers and disorders
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Cancer Treatment and Pharmacology
- Integrated Circuits and Semiconductor Failure Analysis
- Neutropenia and Cancer Infections
- Space Satellite Systems and Control
- Epilepsy research and treatment
- Gastrointestinal disorders and treatments
- Radiomics and Machine Learning in Medical Imaging
- Advancements in Semiconductor Devices and Circuit Design
- Acute Lymphoblastic Leukemia research
- Cardiac Imaging and Diagnostics
- Spacecraft Design and Technology
- COVID-19 and healthcare impacts
Northwestern University
2020-2024
Northwestern Memorial Hospital
2020
Australian National University
2009
Abstract Primary cutaneous γδ T cell lymphomas (PCGDTLs) represent a heterogeneous group of uncommon but aggressive cancers. Herein, we perform genome-wide DNA, RNA, and receptor (TCR) sequencing on 29 lymphomas. We find that PCGDTLs are not uniformly derived from Vδ2 cells. Instead, the cell-of-origin depends tissue compartment which derived. Lymphomas arising outer layer skin Vδ1 cells, predominant in epidermis dermis. In contrast, panniculitic arise fat. also show TCR chain usage is...
Abstract Background Chronic lymphocytic leukemia (CLL) and other non-Hodgkin’s lymphomas (NHLs) lead to broad immunosuppression, conferring a greater risk for morbidity mortality from SARS-CoV-2. Our study analyzed antibody (Ab) seropositivity SARS-CoV-2 vaccination in patients with these cancers. Methods In the final analysis, 240 were involved, was defined as positive total or spike protein Ab. Results Seropositivity 50% CLL, 68% WM, 70% remaining NHLs. Moderna led higher compared Pfizer...
"CLO22-043: Humoral Immune Response Following COVID-19 Vaccination in Patients With Chronic Lymphocytic Leukemia and Other Indolent Lymphomas: A Large, Single-Center Observational Study" published on 31 Mar 2022 by National Comprehensive Cancer Network.
A 21-point risk score for heart failure (HF) has been developed patients with acute myeloid leukemia (AML), stratifying into three groups: low, moderate, and high-risk. In this study, 193 AML treated anthracycline-based therapy were stratified using the score, its prognostic utility HF events all-cause mortality at one year of follow-up evaluated. occurred in 18% (34/193) anthracycline-treated patients. Global longitudinal strain (GLS) was more negative among without (-19 ± 3 vs. -17 4%)....
Introduction: GI FL is a rare disease, accounting for less than 5% of non-Hodgkin's lymphomas (NHL). We formed consortium to clarify baseline features, common practices and survival outcomes in primary FL. Methods: A retrospective analysis 182 patients (pts) with from 8 institutions was conducted. Overall (OS) progression-free (PFS) were assessed. Cox regression models used estimate hazard ratios (HR) 95% confidence intervals (CI). Results: Median age at diagnosis (dx) 60 years (yrs) (IQR:...
e19192 Background: Many systemic anti-cancer therapies (chemotherapy, immunotherapy and radiation) have known cardiac toxicities. The field of cardio-oncology aims to optimize the health cancer patients. Our goal was evaluate baseline clinical characteristics, referral patterns rate adverse outcomes in patients referred a single clinic at tertiary care academic center. Methods: We performed retrospective review 100 consecutive who established between 2011-2019. Baseline data collected from...
Introduction: HF is a major cause of morbidity and mortality in AML patients. This study was designed as an external evaluation risk score to determine the patients treated with anthracyclines for AML. Methods: A validation cohort composed 204 consecutive anthracyclines. 2DSTE performed using TomTec software obtain baseline GLS values. LVEF calculated modified Simpson’s biplane method. hospitalizations were defined standard clinical criteria. The included > - 15% (6 points), LVEF<50%...
2634 Background: High tumor mutational burden (TMB-H) has shown promise as a predictive biomarker in certain tumors, but broad applicability across tumors is unclear. In 2020, pembrolizumab was approved for treatment refractory metastatic or unresectable solid with TMB ≥10 mutations/megabase based on exploratory analysis of the KEYNOTE-158 study. Growing evidence suggest limitations TMB-H tumors. Our aim to evaluate outcomes patients (pts) advanced microsatellite-stable (MSS) treated immune...