A5006223942- Chemotherapy-induced cardiotoxicity and mitigation
- Acute Myeloid Leukemia Research
- Heart Failure Treatment and Management
- Histone Deacetylase Inhibitors Research
- Cancer Treatment and Pharmacology
- Cardiac Imaging and Diagnostics
- Ultrasound in Clinical Applications
- Electrostatic Discharge in Electronics
- Silicon Carbide Semiconductor Technologies
- Advancements in Semiconductor Devices and Circuit Design
- Hemodynamic Monitoring and Therapy
- Pulmonary Hypertension Research and Treatments
Northwestern Memorial Hospital
2024
Northwestern University
2019-2023
Cardiovascular events, including heart failure and arrhythmias, following chimeric antigen receptor (CAR) T-cell therapy are increasingly recognized. Although global longitudinal strain (GLS) has demonstrated prognostic utility for other cancer therapy-related cardiac dysfunction, less is known regarding the association of GLS with adverse events CAR therapy.To determine baseline cardiovascular in adults receiving CAR-T cell therapy.Patients who had an echocardiogram within 6 months prior to...
Abstract Background Patients with acute myeloid leukemia (AML) are surviving longer. There no data on changes in myocardial mechanics from standard of care low‐dose anthracycline‐based induction chemotherapy older patients AML. The aim this study was to demonstrate the potential utility strain imaging detecting early left ventricular function patient population after chemotherapy. Methods Thirty two enrolled ECOG‐ACRIN E2906 (cytarabine and daunorubicin vs clofarabine [Genzyme/Sanofi]) 2011...
A 21-point risk score for heart failure (HF) has been developed patients with acute myeloid leukemia (AML), stratifying into three groups: low, moderate, and high-risk. In this study, 193 AML treated anthracycline-based therapy were stratified using the score, its prognostic utility HF events all-cause mortality at one year of follow-up evaluated. occurred in 18% (34/193) anthracycline-treated patients. Global longitudinal strain (GLS) was more negative among without (-19 ± 3 vs. -17 4%)....
Introduction: HF is a major cause of morbidity and mortality in AML patients. This study was designed as an external evaluation risk score to determine the patients treated with anthracyclines for AML. Methods: A validation cohort composed 204 consecutive anthracyclines. 2DSTE performed using TomTec software obtain baseline GLS values. LVEF calculated modified Simpson’s biplane method. hospitalizations were defined standard clinical criteria. The included > - 15% (6 points), LVEF<50%...