A5102873696- CAR-T cell therapy research
- Chemotherapy-induced cardiotoxicity and mitigation
- Advancements in Semiconductor Devices and Circuit Design
- Lung Cancer Diagnosis and Treatment
- Integrated Circuits and Semiconductor Failure Analysis
- Genetic factors in colorectal cancer
- Cardiac Imaging and Diagnostics
- Interactive and Immersive Displays
- Child Nutrition and Water Access
- Electrostatic Discharge in Electronics
- Estrogen and related hormone effects
- Innovative Human-Technology Interaction
- Lung Cancer Treatments and Mutations
- Biomedical Ethics and Regulation
- Medical Imaging Techniques and Applications
- Polymer Nanocomposite Synthesis and Irradiation
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Cancer Immunotherapy and Biomarkers
- Biosimilars and Bioanalytical Methods
- Semiconductor materials and devices
- Teaching and Learning Programming
- Cancer Genomics and Diagnostics
- Silicon Carbide Semiconductor Technologies
- BRCA gene mutations in cancer
Northwestern University
2017-2025
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2025
Cardiovascular events, including heart failure and arrhythmias, following chimeric antigen receptor (CAR) T-cell therapy are increasingly recognized. Although global longitudinal strain (GLS) has demonstrated prognostic utility for other cancer therapy-related cardiac dysfunction, less is known regarding the association of GLS with adverse events CAR therapy.To determine baseline cardiovascular in adults receiving CAR-T cell therapy.Patients who had an echocardiogram within 6 months prior to...
Cardiovascular adverse events (CVAEs) are recognized complications of chimeric antigen receptor (CAR) T-cell therapies. However, data lacking regarding subtypes that develop in patients with different malignancies, and little is known about the timeframe which cardiotoxicities most likely to occur post-CAR In this study, 211 patients, including 138 lymphoma 66 myeloma who received CAR therapies were retrospectively identified. Of these, 42 (19.9%) developed CVAEs post-treatment. Myeloma...
Computational thinking skills will be important for the next generation of students. However, there is a disparity in populations joining field. Integrating computational into artistic fields has shown to increase participation computer science. In this paper, we present our initial design prototype TunePad, sound composition tablet application controlled by block-based programming environment. TunePad designed introduce learners and prepare them text-based coding environments. From...
12033 Background: The PACIFIC trial was a randomized phase 3 study which evaluated the use of Durvalumab as consolidation therapy after definitive chemoradiation for patients with unresectable non-metastatic NSCLC. There significant improvement in progression free survival and overall survival. It established standard approach management. Due to nonspecific activation immune system, related adverse events are commonly associated ICIs. Immune cardiotoxicity is less common however may present...
Global longitudinal strain (GLS) has been used to identify patients at risk for cancer-therapy related cardiac dysfunction (CTRCD). However, there is limited data on the effectiveness of initiating cardioprotective therapy based a strain-guided strategy in early stage HER2+ breast cancer patients. This randomized clinical trial assessed if treatment with carvedilol can prevent development CTRCD non-anthracycline regimens. Study participants were prospectively assigned one four arms. Patients...
Introduction: Chimeric Antigen Receptor (CAR)-T cell therapy has shown improved response rates in relapsed and refractory B-cell malignancies, but been associated with adverse cardiac events. We investigated the correlation between pre-existing clinical factors CAR-T therapy-related cardiovascular (CV) Methods: Adult patients undergoing at Northwestern Memorial Hospital 2016 2020 were identified. A comprehensive retrospective chart review was performed. CV events including death,...
Introduction: Cardiovascular events following Chimeric Antigen Receptor (CAR) T-cell therapy are increasingly recognized. Left ventricular systolic dysfunction and arrhythmias the most common cardiac toxicities seen. Thus, risk stratification in this population is important, especially adults with subclinical disease. Although left global longitudinal strain (LV-GLS) has demonstrated prognostic utility for other cancer related dysfunction, less known regarding predictors of adverse CAR...
10602 Background: As the use of circulating tumor DNA (ctDNA) is more widely implemented, incidental identification pathogenic variants reflecting germline alterations in cancer predisposition genes will occur frequently. Such mutations are expected to have a high mutant allele frequency (MAF) or typically associated with inherited syndromes. When similar analysis was conducted by our group, we found that MAF about 30% greater BRCA1/ 2 confirmed putative patients breast (Jacob et al &...