A5058482897- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Teaching and Learning Programming
- Prostate Cancer Treatment and Research
- Biomedical and Engineering Education
- Museums and Cultural Heritage
- Mosquito-borne diseases and control
- Innovative Teaching and Learning Methods
- Cancer, Lipids, and Metabolism
- Fatty Acid Research and Health
- Educational Games and Gamification
- Metabolomics and Mass Spectrometry Studies
- Endoplasmic Reticulum Stress and Disease
- Interactive and Immersive Displays
- Augmented Reality Applications
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Phytochemicals and Antioxidant Activities
- Experimental Learning in Engineering
- Occupational and environmental lung diseases
- Mobile Learning in Education
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autophagy in Disease and Therapy
- Lipid metabolism and biosynthesis
- Mitochondrial Function and Pathology
The University of Sydney
2017-2023
Asbestos Diseases Research Institute
2023
New York Hall of Science
2020-2022
Northwestern University
2012-2019
Robert Bosch (India)
2017
Museum of Science and Industry
2017
University of British Columbia
2010-2016
Vancouver General Hospital
2014
The Prostate Centre
2012
// Valentina R. Minciacchi 1 , Sungyong You Cristiana Spinelli Samantha Morley 2 Mandana Zandian Paul-Joseph Aspuria 3 Lorenzo Cavallini 1,4 Chiara Ciardiello 1,5 Mariana Reis Sobreiro Matteo Morello Geetanjali Kharmate 6 Su Chul Jang 7 Dae-Kyum Kim Elham Hosseini-Beheshti Emma Tomlinson Guns Martin Gleave Yong Song Gho Suresh Mathivanan 8 Wei Yang Michael Freeman 1,2 and Dolores Di Vizio Division of Cancer Biology Therapeutics, Departments Surgery, Biomedical Sciences Pathology Laboratory...
Prostate cancer is the leading type of diagnosed in men. In 2010, ~217,730 new cases prostate were reported United States. Prompt diagnosis disease can substantially improve its clinical outcome. Improving capability for early detection, as well developing therapeutic targets advanced are research priorities that will ultimately lead to better patient survival. Eukaryotic cells secrete proteins via distinct regulated mechanisms which either ER/Golgi dependent or microvesicle mediated. The...
Prostate cancer cells exhibit altered cellular metabolism but, notably, not the hallmarks of Warburg metabolism. increased de novo synthesis fatty acids (FA); however, little is known about how extracellular FAs, such as those in circulation, may support prostate progression. Here, we show that increasing FA availability intracellular triacylglycerol content cultured patient-derived tumor explants, LNCaP and C4-2B spheroids, a range (LNCaP, C4-2B, 22Rv1, PC-3), epithelial (PNT1)....
Chloroquine (CQ), a lysosomotropic agent, is commonly used to inhibit lysosomal degradation and macroautophagy/autophagy. Here we investigated the cell-extrinsic effects of CQ on secretion. We showed that autophagy inhibition by altered secretome, induced release Atg8 orthologs receptors. Atg8-family proteins, in particular, were secreted inside small extracellular vesicles (sEVs) lipidation-dependent manner. treatment enhanced proteins sEVs. Using full-length ATG16L1 an mutant enables...
// Elham Hosseini-Beheshti 1, 3 , Wendy Choi Louis-Bastien Weiswald 4 Geetanjali Kharmate Mazyar Ghaffari Mani Roshan-Moniri Mohamed D. Hassona Leslie Chan Mei Yieng Chin Isabella T. Tai Paul S. Rennie 2, Ladan Fazli Emma Tomlinson Guns 1 Department of Experimental Medicine University British Columbia, Vancouver, V6H 3Z6, Canada 2 Urologic Sciences The Vancouver Prostate Centre Division Gastroenterology, Correspondence to: Guns, e-mail: eguns@prostatecentre.com Keywords: exosomes, cancer...
Exosomes proteins and microRNAs have gained much attention as diagnostic tools biomarker potential in various malignancies including prostate cancer (PCa). However, the role of exosomes membrane-associated receptors, particularly epidermal growth factor receptor (EGFR) mediators cell proliferation invasion PCa progression remains unexplored. EGFR is frequently overexpressed has been associated with aggressive forms PCa. While cells tissues express EGFR, it unknown whether derived from or...
Understanding electrical circuits can be difficult for novices of all ages. In this paper, we describe a science museum exhibit that enables visitors to make on an interactive tabletop and observe simulation electrons flowing through the circuit. Our goal is use multiple representations help convey basic concepts current resistance. To study visitor interaction learning, tested design at popular with 60 parent-child dyads in three conditions: control condition no electron simulation;...
The diabetic heart switches to exclusively using fatty acid (FA) for energy supply and does so by multiple mechanisms including hydrolysis of lipoproteins lipoprotein lipase (LPL) positioned at the vascular lumen. We determined mechanism that leads an increase in LPL after diabetes. Diazoxide (DZ), agent decreases insulin secretion causes hyperglycemia, induced a substantial activity This paralleled robust phosphorylation Hsp25, decreasing its association with PKCdelta, allowing this protein...
Glycogen is an immediate source of glucose for cardiac tissue to maintain its metabolic homeostasis. However, excess brings about structural and physiological impairments. Previously, we have demonstrated that in hearts from dexamethasone (Dex)-treated animals, glycogen accumulation was enhanced. We examined the influence 5'-AMP-activated protein kinase (AMPK) on entry synthase as a means regulating this stored polysaccharide. After Dex, had limited contribution toward development whole body...
Computational thinking skills will be important for the next generation of students. However, there is a disparity in populations joining field. Integrating computational into artistic fields has shown to increase participation computer science. In this paper, we present our initial design prototype TunePad, sound composition tablet application controlled by block-based programming environment. TunePad designed introduce learners and prepare them text-based coding environments. From...