A5069030183- Pharmacogenetics and Drug Metabolism
- COVID-19 Clinical Research Studies
- Vitamin D Research Studies
- Ginseng Biological Effects and Applications
- Estrogen and related hormone effects
- Prostate Cancer Treatment and Research
- Liver Disease Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- Hormonal and reproductive studies
- Growth Hormone and Insulin-like Growth Factors
- Pharmacological Receptor Mechanisms and Effects
- Long-Term Effects of COVID-19
- Diet, Metabolism, and Disease
- Eicosanoids and Hypertension Pharmacology
- PARP inhibition in cancer therapy
- Cancer, Lipids, and Metabolism
- Pharmaceutical Practices and Patient Outcomes
- Renal function and acid-base balance
- Vitamin C and Antioxidants Research
- Computational Drug Discovery Methods
- Alcohol Consumption and Health Effects
- Clinical Laboratory Practices and Quality Control
Larkin University
2018-2024
Sylhet MAG Osmani Medical College
2020-2022
Roosevelt University
2014-2017
Vancouver General Hospital
2012-2014
University of British Columbia
2009-2014
Shaheed Suhrawardy Medical College
2013
Bombay College of Pharmacy
2008
Stony Brook University
1986
State University of New York
1986
UConn Health
1986
Cell envelopes of Salmonella typhimurium and Escherichia coli were disrupted in a French pressure cell fractionated by successive cycles sedimentation floatation density gradient centrifugation. This permitted the identification isolation several membrane fractions addition to major inner murein-outer fractions. One these (fraction OML) accounted for about 10% total envelope protein, is likely include murein-membrane adhesion zones that are seen electron micrographs plasmolyzed cells....
The biological activities of vitamin D<sub>3</sub> are exerted through the dihydroxy metabolite [1α,25(OH)<sub>2</sub>D<sub>3</sub>]. Hepatic biotransformation 1α,25(OH)<sub>2</sub>D<sub>3</sub> by cytochrome P450 (P450) enzymes could be an important determinant bioavailability in serum and tissues. In present study, we investigated comparative mouse human liver microsomes determined effects commonly used drugs on catabolism 1α,25(OH)<sub>2</sub>D<sub>3</sub>. Severe symptoms D deficiency...
Purpose: Remdesivir, a drug originally developed against Ebola virus, is currently recommended for patients hospitalized with coronavirus disease of 2019 (COVID-19). In spite United States Food and Drug Administration’s recent assent remdesivir as the only approved agent COVID-19, there limited information available about physicochemical, metabolism, transport, pharmacokinetic (PK), drug-drug interaction (DDI) properties this drug. The objective in silico simulation work was to simulate...
Vitamin D3 is an endogenous fat-soluble secosteroid, either biosynthesized in human skin or absorbed from diet and health supplements. Multiple hydroxylation reactions several tissues including liver small intestine produce different forms of vitamin D3. Low serum D levels a global problem which may origin differential absorption following supplementation. The objective the present study was to estimate physicochemical properties, metabolism, transport pharmacokinetic behavior derivatives...
Pharmacogenomics (PGx) can facilitate the transition to patient-specific drug regimens and thus improve their efficacy reduce toxicity. The aim of this study was evaluate overlap PGx classification for absorption, distribution, metabolism, elimination (ADME)-related genes in U.S. Food Drug Administration (FDA) labeling Clinical Pharmacogenetics Implementation Consortium (CPIC) database. FDA-approved drugs ADME were identified CPIC Drugs filtered by association with (pharmacokinetics)-related...
Background. To examine the association between low-density lipoprotein (LDL) and high-density (HDL) levels liver enzyme functions. Methods. The National Health Nutrition Examination Survey (NHANES) data from 1999 to 2012 was used enzymes lipid amongst adults in United States. Results. Sixteen percent had ALT > 40 U/L, 11% AST 96% ALP 120 U/L. Age, gender, race/ethnicity showed significant with LDL, HDL, triglycerides levels. LDL greater than borderline high associated little over two...
ABSTRACT 20( S )‐Protopanaxadiol (aPPD), a ginseng sapogenin, has been shown to be promising anti‐cancer compound and anti‐depressant agent. Although the bacterial biotransformation of ginsenosides studied thoroughly, few have reported on cytochrome P450 (P450) mediated metabolism aPPD. Taken orally, aPPD must first undergo absorption in intestine before further liver. The present study investigated comparative profile human intestinal microsomes (HIM) liver (HLM) characterized enzymes...
The peripheral zone (PZ) and transition (TZ) represent about 70% of the human prostate gland with each having differential ability to develop cancer. Androgens their receptor are primary driving cause cancer growth eventually castration-resistant (CRPC). De novo steroidogenesis has been identified as a key mechanism that develops during CRPC. Currently, there is very limited information available on tissue steroidogenesis. purpose present study was investigate steroid metabolism in tissues...