A5013555661- COVID-19 Impact on Reproduction
- Cardiovascular Health and Risk Factors
- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Health disparities and outcomes
- Cardiovascular Function and Risk Factors
- COVID-19 and healthcare impacts
- Cardiovascular Disease and Adiposity
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- Climate Change and Health Impacts
- Genomic variations and chromosomal abnormalities
- Enzyme Structure and Function
- Atherosclerosis and Cardiovascular Diseases
- Hemodynamic Monitoring and Therapy
- Electrostatic Discharge in Electronics
- Healthcare cost, quality, practices
- Air Quality and Health Impacts
- Thermoregulation and physiological responses
- Radiation Dose and Imaging
- Fibroblast Growth Factor Research
- Magnesium in Health and Disease
- Trypanosoma species research and implications
- Iron and Steelmaking Processes
- Silicon Carbide Semiconductor Technologies
Northwestern University
2021-2024
Northwestern University
2022
Purdue University West Lafayette
2019
Femoral atherosclerotic plaques are less inflammatory than carotid histologically, but limited cell-level data exist regarding comparative immune landscapes and polarization at these sites. We investigated intraplaque leukocyte phenotypes transcriptional in 49 patients undergoing femoral (n = 23) or 26) endarterectomy using single-cell RNA-Seq (scRNA-Seq; n 13), flow cytometry 24), IHC 12). Comparative scRNA-Seq of CD45+-selected leukocytes from 9; 35,265 cells) 4; 30,655 plaque revealed...
Cardiovascular events, including heart failure and arrhythmias, following chimeric antigen receptor (CAR) T-cell therapy are increasingly recognized. Although global longitudinal strain (GLS) has demonstrated prognostic utility for other cancer therapy-related cardiac dysfunction, less is known regarding the association of GLS with adverse events CAR therapy.To determine baseline cardiovascular in adults receiving CAR-T cell therapy.Patients who had an echocardiogram within 6 months prior to...
Pregnant persons are at increased risk of severe coronavirus disease 2019 (COVID-19) and adverse obstetric outcomes. Understanding maternal antibody response, duration, transplacental transfer after acute respiratory syndrome 2 (SARS-CoV-2) infection COVID-19 vaccination is important to inform public health recommendations.
Ethnic and national identity may influence cardiovascular health (CVH)-related behaviors, such as dietary preference. To better understand how acculturation is related to CVH among South Asian American adults, we evaluated the association of self-rated with factors participants Mediators Atherosclerosis in Asians Living America (MASALA) Study.Multivariable linear regression quantified associations [1 (low identity) 10 (high identity)] factors, including measures cholesterol, blood pressure,...
The correlation of ERBB2 copy number gain (CNG) from tissue or circulating tumor DNA (ctDNA) by next-generation sequencing (NGS) with standard HER2 evaluation is not well understood.We retrospectively identified patients CNG on commercial NGS. We described their clinical-pathologic features and calculated the positive predictive value (PPV) NGS for HER2-positivity IHC FISH testing.176 had revealing an (112 91 ctDNA). cancer subtypes most cases were breast (n = 67), non-small cell lung 25),...
Abstract Background The epidemiology of SARS-CoV-2 has varied significantly across age groups, specifically children. Immune and physiologic changes in pregnancy can lead to increased susceptibility infection. Pregnant people were at risk severe COVID-19 infections obstetric complications, particularly before vaccine availability. We investigated epidemiologic trends cases pregnant over time compared the general population various subgroups. hypothesized that rates SAR-CoV-2 infection may...
Introduction: Numerous studies across the world have characterized effect of extreme heat exposure on cardiovascular health (CVH) using myriad data sources and methodologies. Here we review these synthesize their methodological approaches findings to identify common clinical factors associated with CVH following exposure. Similarities differences different global settings are identified discussed. Hypothesis: is modulated by exacerbation due heat, which will vary according study population’s...
Bacterial ATP-binding cassette transporters are a superfamily of transport systems involved in the import various molecules including amino acids, ions, sugars, and peptides. In lactic acid bacteria Lactococcus lactis, oligopeptide-binding protein A (OppA) binds peptides for to support nitrogen metabolism cell growth. The OppA is great interest because it can bind over broad variety lengths sequences; however, current methods study peptide binding have employed low throughput, endpoint, or...
Parasitemia and inflammatory markers are cross-sectionally associated with chronic Chagas cardiomyopathy (CCC) among patients Trypanosoma cruzi. However, the prospective association of parasite load host immune response-related characteristics CCC (that is, progressors) T. cruzi seropositive individuals has only been partially defined. In a cohort in Montes Claros São Paulo, Brazil who were followed over 10 years, we identified baseline systemic inflammation decline cardiac function and/or...
Key Points FGF23 has a nonlinear positive association with incident CKD among healthy, middle-aged adults. The relationship between and was only significant participants cFGF23 levels in the highest quartile. is not associated 10-year change eGFR or UACR Background of fibroblast growth factor 23 (FGF23) been examined older but younger populations. Methods Linear regression models were used to examine associations c-terminal (cFGF23) intact (iFGF23) (1995–96 2005–06) urine...
Background: Social vulnerability is an important determinant of cardiovascular health. Prior investigations have shown strong associations social determinants health with risk factors, imaging findings, and clinical events. However, limited data exist regarding the potential role related physiologic stressors on tissue-level pathology. Methods: We analyzed linked autopsy reports from 853 decedent individuals who underwent 4/6/2002 to 4/1/2021 at a large urban medical center. The mean age...
Abstract Background Pregnant persons are at increased risk of severe COVID-19 and adverse obstetric outcomes. Understanding maternal antibody response transplacental transfer after SARS-CoV-2 infection vaccination is important to inform public health recommendations. Methods This prospective observational cohort study included 351 birthing individuals who had or during pregnancy. IgG IgM S1 receptor binding domain were measured in cord blood. Antibody levels ratios compared across 1) disease...
Older age is a key risk factor for adverse outcomes in critically ill patients with COVID-19. However, few studies have investigated whether preexisting comorbidities and acute physiologic ICU factors modify the association between death.
Introduction: Since the onset of COVID-19 pandemic, large geographic differences in mortality rates have emerged, with higher predominantly Black and Latinx neighborhoods. In this analysis we examined community-level across city Chicago to better understand how are associated COVID19 mortality. Hypothesis: We hypothesized there would be an association between social vulnerability rates. Methods: publicly available data from Cook County Medical Examiner (Illinois) all known deaths as August...
Introduction: Chimeric Antigen Receptor (CAR)-T cell therapy has shown improved response rates in relapsed and refractory B-cell malignancies, but been associated with adverse cardiac events. We investigated the correlation between pre-existing clinical factors CAR-T therapy-related cardiovascular (CV) Methods: Adult patients undergoing at Northwestern Memorial Hospital 2016 2020 were identified. A comprehensive retrospective chart review was performed. CV events including death,...
Introduction: Cardiovascular events following Chimeric Antigen Receptor (CAR) T-cell therapy are increasingly recognized. Left ventricular systolic dysfunction and arrhythmias the most common cardiac toxicities seen. Thus, risk stratification in this population is important, especially adults with subclinical disease. Although left global longitudinal strain (LV-GLS) has demonstrated prognostic utility for other cancer related dysfunction, less known regarding predictors of adverse CAR...
7564 Background: Advancements in treatment over the last decade have greatly improved survival B cell non-Hodgkin’s lymphoma (NHL), yet not all patients (pts) benefit same. Non-Hispanic Black (NHB), uninsured and lower socioeconomic status pts continue to suffer worse survival. However, impact of neighborhood deprivation on disability has been explored. We aimed assess association between free (DFS) NHL pts. Methods: 258 aggressive treated 2005-2020 were included. Pts without documented...
6624 Background: Cancer cachexia is a muscle wasting syndrome characterized by anorexia, asthenia, and weight loss. Cachexia rates are as high 35% for aggressive B-cell Non-Hodgkin Lymphomas (B-NHL), considered an independent factor in cancer outcomes compared to other disease burden markers. However, there remains no set protocol identify hematologic patients at risk cachexia, current imaging-based measures can be costly burdensome. Weight loss grading scale (WLGS) newly validated method...
Abstract Background SARS-CoV-2 infection in pregnancy can cause placental abnormalities such as “SARS-CoV-2 placentitis” (histiocytic intervillositis, perivillous fibrin deposition, and villous trophoblast necrosis) that is irrespective of severity associated with stillbirth. Mechanisms injury are poorly understood. We investigated gene expression through next generation sequencing (NGS)-based spatial transcriptomics placentas from controls. Methods Cases normal histopathology [n=4],...
Introduction: Women are at higher risk for heart failure and mortality after myocardial infarction (MI) than men. Differences in tissue-level response to ischemia MI women vs. men incompletely understood have the potential contribute differences post-MI sequelae such as sudden death. Methods: We analyzed clinical data paired autopsy reports from decedent patients who underwent a large urban medical center 4/6/2002 4/1/2021. Using completed by trained pathologist, we then determined presence...
Background: Pregnant persons are at increased risk of severe COVID-19 and adverse obstetric outcomes. Understanding maternal antibody response transplacental transfer after SARS-CoV-2 infection vaccination is important to inform public health recommendations.Methods: This prospective observational cohort study included 351 birthing individuals who had or during pregnancy. IgG IgM S1 receptor binding domain were measured in cord blood. Antibody levels ratios compared across 1) disease...
Abstract Background Pregnant people and fetuses are uniquely vulnerable to SARS-CoV-2, a driver of inflammation immune dysregulation. Prior investigations have shown that pregnant with SARS-CoV-2 at higher risk severe illness, mortality, obstetric complications. We investigated the impact infection severity latency on maternal infant cytokine levels. Methods collected blood cord delivery from mother-infant dyads (Chicago, IL; 3/2020-1/2022). A multiplex panel (IsoPlexis) was run plasma 93...