A5017006389- Sleep and related disorders
- Dietary Effects on Health
- Diet and metabolism studies
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Obstructive Sleep Apnea Research
- Cardiovascular Health and Risk Factors
- Body Composition Measurement Techniques
- Pelvic floor disorders treatments
- Physical Activity and Health
- Obesity, Physical Activity, Diet
- Urinary Tract Infections Management
- Health disparities and outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Liver Disease Diagnosis and Treatment
- Nutrition and Health in Aging
- Sleep and Work-Related Fatigue
- HIV, Drug Use, Sexual Risk
- Diverticular Disease and Complications
- Advanced Causal Inference Techniques
- Cardiovascular and Diving-Related Complications
- Food Security and Health in Diverse Populations
- COVID-19 epidemiological studies
- Single-cell and spatial transcriptomics
- Trypanosoma species research and implications
Northwestern University
2021-2025
Time-restricted eating (TRE), without calorie counting, has become a popular weight loss strategy, yet long-term randomized trials evaluating its efficacy are limited.
Importance Time-restricted eating (TRE) has become increasingly popular, yet longer-term randomized clinical trials have not evaluated its efficacy and safety in patients with type 2 diabetes (T2D). Objective To determine whether TRE is more effective for weight reduction glycemic control than daily calorie restriction (CR) or a condition adults T2D. Design, Setting, Participants This 6-month, parallel-group, trial was performed between January 25, 2022, April 1, 2023, at the University of...
Abstract Background Youth use different forms of screen time (e.g., streaming, gaming) that may be related to body mass index (BMI). Screen is non-independent from other behaviors, including physical activity and sleep duration. Statistical approaches such as isotemporal substitution or compositional data analysis (CoDA) can model associations between these behaviors health outcomes. Few studies have examined types time, activity, duration simultaneously in relation BMI. Methods Data were...
Femoral atherosclerotic plaques are less inflammatory than carotid histologically, but limited cell-level data exist regarding comparative immune landscapes and polarization at these sites. We investigated intraplaque leukocyte phenotypes transcriptional in 49 patients undergoing femoral (n = 23) or 26) endarterectomy using single-cell RNA-Seq (scRNA-Seq; n 13), flow cytometry 24), IHC 12). Comparative scRNA-Seq of CD45+-selected leukocytes from 9; 35,265 cells) 4; 30,655 plaque revealed...
Abstract Study Objective The objective of this study was to examine the association between timing dietary macronutrients and sodium intake sleep quantity quality. Methods This a cross-sectional that included 34 adults 21 50 years age. main outcome measures were assessed from three nights wrist actigraphy including duration, fragmentation, wake after onset (WASO), one night polysomnography (PSG), rapid eye movement (REM) sleep, non-REM stage 2 (N2), 3 (N3), WASO. Multiple linear regression...
Gender and age are well-established determinants of health sleep that influence overall health, which also often varies by gender age. Sleep architecture is an important component health. The goal this analysis was to examine whether associations between stages differ in the absence moderate-severe obstructive apnea (OSA) a rural setting Brazil. This study conducted polysomnography recordings Baependi Heart Study, cohort Brazilian adults. Our sample included 584 women 309 men whose...
(Abstracted from Urogynecology 2024;30:765–773 Lower urinary tract symptoms appear in a large percentage of women at some point their lives, and represent significant burden health care quality life. Recent studies have reported this prevalence as high 45% for incontinence (UI) 20% pelvic floor disorders.
Abstract Study Objectives Decline in physical functioning older adults has been associated with higher risk of chronic diseases. Subjective sleep disturbances have declines aging. We examined the association between objectively measured characteristics and 6-minute walk distance, a marker functional capacity, sample adults. Methods This analysis included 199 participants who were enrolled Disparities Sleep Cognitive Outcomes (DISCO) study, longitudinal cohort aged ≥55 years. Exposures...
Chronotype indicates a person’s “circadian preference,” that is, the time of day when they prefer to perform certain activities (e.g. “morning” vs “evening” person). Sleep timing is related chronotype but also constrained by social requirements. When sleep does not align with chronotype, circadian disruption can occur, and impairs cardiometabolic health. There are well-known racial disparities in health whereby Black adults at higher risk. It well-known, however, whether within each varies...
Background/Objectives: Obesity is associated with chronic systemic inflammation and elevated levels of inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), C-reactive protein (CRP). Weight loss through lifestyle interventions can reduce in adults obesity. Time-restricted eating (TRE) calorie restriction (CR) are two popular diet that produce clinically significant weight loss. However, to date, no studies have directly compared the effects TRE versus...
Introduction: Heart failure (HF) morbidity and mortality are disparately greater among Black individuals compared with their peers from other racial ethnic backgrounds. Sleep, physical activity (PA), sedentary behavior (SB) each associated incident HF, but these interdependent behaviors, integration of exposures is needed to best understand the holistic risk for HF. Therefore, we examined association between 24-hour compositional distribution behaviors including HF subtypes (i.e., preserved...
The purpose of this secondary analysis is to compare the effects two popular weight loss regimens, time-restricted eating (TRE) and daily calorie restriction (CR), on mood quality-of-life measures in adults with obesity. Ninety participants were randomized one three interventions for 12 months: 8 h TRE (eating only between 12:00 8:00 p.m., no counting); CR (25% energy daily); or no-intervention control group. Questionnaires administered measure (Beck Depression Inventory-II (BDI-II), Profile...
Abstract Study Objectives People with diabetes and prediabetes are more likely to have sleep-disordered breathing (SDB), but few studies examined sleep architecture in people or the absence of moderate-severe SDB, which was aim our cross-sectional study. Methods This sample is from Baependi Heart Study, a family-based cohort adults Brazil. About 1074 participants underwent at-home polysomnography (PSG). Diabetes defined as fasting glucose >125 mg/dL HbA1c > 6.4 mmol/mol taking...
Abstract Sleep and circadian disturbances are common experienced more often by Black compared to White individuals. We conducted an observational study of sleep that was ancillary ongoing cohort study, Coronary Artery Disease in Young Adults (CARDIA). The goal the will be examine potential determinants sleep/circadian disparities between adults future analyses. Herein we describe design methodology. Our coincided with Year 35 examination CARDIA two phases (due SARS-COV-2 pandemic). Phase 1...
Routine screening for urinary incontinence (UI) by primary care providers (PCPs) is recommended.
Sleep characteristics are associated with cardiovascular disease (CVD) risk and both sleep CVD vary by gender. Our objective was to examine associations between polysomnographic after excluding moderate-severe apnea, whether gender modifies these associations.
People with diabetes are more likely to have obstructive sleep apnea, but there few studies examining architecture in people diabetes, especially the absence of moderate-severe apnea. Therefore, we compared among prediabetes or neither condition, whilst excluding
Background: The Physical Activity Guidelines 2nd Edition recommends ≥2 days of resistance training (RT). Evidence supports a dose-response relation between RT volume and cardiometabolic health. We examined whether guidelines were associated with lower all-cause mortality. Methods: Participants from the 1999-2006 NHANES cycles (N = 5855) self-reported past 30 physical activity including number sessions, average session duration in minutes, type. Mortality was ascertained linked National Death...
Introduction: Sleep health is comprised of many dimensions, including duration, quality and sleep disorders. Prior work found that Black adults have worse than White adults, but the underlying reasons are unknown. Our goal was to examine possible determinants racial disparities in health. We hypothesized would be participants, this partly explained by clinical, psychosocial lifestyle risk factors. Methods: used cross-sectional data from ancillary study Coronary Artery Risk Development Young...
Introduction: Body mass index (BMI) and waist circumference (WC) capture related but distinct measures of adiposity (overall vs central adiposity). It is unclear if changes in WC are associated with incident diabetes mellitus (DM) whether the relation similar between BMI groups. Methods: We included 3,234 CARDIA participants (61% Black, 63% females, mean age 24.7 [3.7] years at baseline) without prevalent DM from baseline (1985-1986) through exam Year 20 (Y20; 2005-2006). Incident after Y20...