A5025479711- Sleep and related disorders
- Obesity, Physical Activity, Diet
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Obstructive Sleep Apnea Research
- Cognitive Abilities and Testing
- Sleep and Work-Related Fatigue
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Nutritional Studies and Diet
- Diet and metabolism studies
- Language Development and Disorders
- Health disparities and outcomes
- COVID-19 and Mental Health
- Child and Adolescent Psychosocial and Emotional Development
- Aging, Elder Care, and Social Issues
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Risk Factors
- Memory and Neural Mechanisms
- Adolescent and Pediatric Healthcare
- Child Nutrition and Water Access
- Stress Responses and Cortisol
- Resilience and Mental Health
- Dementia and Cognitive Impairment Research
- Neural and Behavioral Psychology Studies
Harvard University
2024
Northwestern University
2019-2024
Harvard University Press
2024
Universidade de São Paulo
2015-2020
University of Surrey
2019
Abstract Diurnal preference (chronotype) is a useful instrument for studying circadian biology in humans. It harbours trait-like dimensions relating to period and sleep homeostasis, but also has ontogenetic components (morningness increases with age). We used the Morningness-Eveningness questionnaire (MEQ) Baependi study, family-based cohort study based small town Minas Gerais, Brazil. The population highly admixed cohesive conservative lifestyle. 825 individuals (497 female) aged 18–89...
Gender and age are well-established determinants of health sleep that influence overall health, which also often varies by gender age. Sleep architecture is an important component health. The goal this analysis was to examine whether associations between stages differ in the absence moderate-severe obstructive apnea (OSA) a rural setting Brazil. This study conducted polysomnography recordings Baependi Heart Study, cohort Brazilian adults. Our sample included 584 women 309 men whose...
<h3>Purpose</h3> Cardiovascular disease (CVD) is a major challenge to global health. The same epidemiological transition scenario replayed as countries develop, but with variations based on environment, culture and ethnic mixture. Baependi Heart Study was set up in 2005 develop longitudinal family-based cohort study that reflects some of the genetic lifestyle-related peculiarities Brazilian populations, order evaluate environmental influences CVD risk factor traits. <h3>Participants</h3>...
Abstract Sleep is modulated by several factors, including sex, age, and chronotype. It has been hypothesised that contemporary urban populations are under pressure towards shorter sleep duration poorer quality. Baependi a small town in Brazil provides window of opportunity to study the influence patterns highly admixed rural population with conservative lifestyle. We evaluated characteristics, excessive daytime sleepiness, chronotype using Pittsburgh Quality Index, Epworth Sleepiness Scale...
Abstract Studying communities at different stages of urbanisation and industrialisation can teach us how timing intensity light affect the circadian clock under real‐life conditions. We have previously described a strong tendency towards morningness in Baependi Heart Study, located small rural town Brazil. Here, we tested hypothesis that this is associated with early phase based on objective measurements (as determined by dim melatonin onset, DLMO, activity) exposure. also analysed well...
To investigate the phenotypic and genetic overlap between anxiety depression symptoms in an admixed population from extended family pedigrees. Participants (n = 1,375) were recruited a cohort of 93 families (mean age±SD 42±16.3, 57% female) rural town Baependi, Brazil. The Hospital Anxiety Depression Scale (HADS) was used to assess symptoms. Heritability estimates obtained by adjusted variance component model. Bivariate analyses performed obtain partition covariance into environmental...
Abstract Study Objectives People with diabetes and prediabetes are more likely to have sleep-disordered breathing (SDB), but few studies examined sleep architecture in people or the absence of moderate-severe SDB, which was aim our cross-sectional study. Methods This sample is from Baependi Heart Study, a family-based cohort adults Brazil. About 1074 participants underwent at-home polysomnography (PSG). Diabetes defined as fasting glucose &gt;125 mg/dL HbA1c &gt; 6.4 mmol/mol taking...
Cardiometabolic risk factors influence white matter hyperintensity (WMH) development: in metabolic syndrome (MetS), higher WMH load is often reported but the relationships between specific cardiometabolic variables, and cognitive performance are uncertain. We investigated these a Brazilian sample (aged 50-85) with (N = 61) without 103) MetS. Stepwise regression models identified effects of demographic variables on (from FLAIR MRI) verbal recall performance. volume was greater MetS, not...
Significant questions remain unanswered regarding the genetic versus environmental contributions to racial/ethnic differences in sleep and circadian rhythms. We addressed this question by investigating association between diurnal preference, using morningness-eveningness questionnaire (MEQ), ancestry within Baependi Heart Study cohort, a highly admixed Brazilian population based rural town. Analysis was performed measures of ancestry, Admixture program, MEQ from 1,453 individuals. found an...
Sleep characteristics are associated with cardiovascular disease (CVD) risk and both sleep CVD vary by gender. Our objective was to examine associations between polysomnographic after excluding moderate-severe apnea, whether gender modifies these associations.
Introduction We examined whether abuse in childhood and/or adolescence was associated with shorter telomere length a pooled analysis of 3,232 participants from five diverse cohorts. also assessed religion or spirituality (R/S) could buffer deleterious effects abuse. Methods Physical and sexual (age <12) 12–18) using the Revised Conflict Tactics Scale questions 1995 Gallup survey. measured relative leukocyte lengths (RTL) quantitative real time polymerase chain reaction. used generalized...
Individual variability in word generation is a product of genetic and environmental influences. The effects on semantic verbal fluency were estimated 1,735 participants from the Brazilian Baependi Heart Study. numbers exemplars produced 60 s broken down into time quartiles because involvement different cognitive processes—predominantly automatic at beginning, controlled/executive end. Heritability unadjusted model for 60-s measure was 0.32. best-fit contained age, sex, years schooling, day...
People with diabetes are more likely to have obstructive sleep apnea, but there few studies examining architecture in people diabetes, especially the absence of moderate-severe apnea. Therefore, we compared among prediabetes or neither condition, whilst excluding
Executive functions (EFs) are a set of cognitive abilities associated with many social and clinical outcomes which believed to be sensitive culture, age educational attainment. Yet, theoretical models EF tasks used measure them were developed mainly for highly educated young adults from countries. Here we assessed EFs in diverse cohort rural town Brazil (Baependi Heart Study: N=1253; 753 females), (18-88 year) schooling (0-23 years) varied widely. Based on popular model (the unity diversity...
Summary We aimed to establish the heritability of polysomnography measures through analysis home recordings from 648 participants in Baependi Heart Study, a rural, family‐based, genetically admixed cohort based southeast Brazil. Sleep staging variables were computed, and narrow‐sense values derived. The ( h 2 ) total sleep time was 0.18 ± 0.08 p = 0.007). Including age sex did not change estimates model. Wake after onset show significant 0.02 0.07, 0.39). unadjusted model for N1 resulted...
Abstract Background Informant reports are commonly regarded as reliable and supplemental alongside respondent cognitive assessments, particularly in low‐literacy settings with absent normative data. We evaluate the performance of Questionnaire on Cognitive Decline Elderly (IQCODE) rural South Africa. Method This study utilizes data from Cognition Dementia a Longitudinal Health Aging Study Africa (HAALSI‐HCAP). The population includes 1,029 unique informants 676 paired participants across two...
<h3>Introduction</h3> Insomnia significantly impacts lifetime morbidity and thus has substantial socioeconomic costs. In developed, high-income countries insomnia prevalence is increasing. However, little known about in less urbanised, lower-income populations. Baependi a Brazilian rural town, which been shown to maintain sleep cycles synchronised natural daylight, spite of electrification. We aimed investigate the components family-based Heart Study cohort, using Severity Index (ISI)...
<h3>Introduction</h3> Circadian rhythmicity is tightly regulated by clock genes. Polymorphic variations of the human PER3 gene have been shown to influence diurnal preference, sleep homeostasis and development mood disorders. However, it unclear whether polymorphisms in this are associated with duration depression symptoms real-life scenarios. We investigated relationship between traits among genotype groups a Brazilian family-based cohort. <h3>Methods</h3> Baependi small rural town Brazil...