A5000727436- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Diet and metabolism studies
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Cardiac Valve Diseases and Treatments
- Adipose Tissue and Metabolism
- Prostate Cancer Diagnosis and Treatment
- Diabetes Treatment and Management
- Cardiovascular and exercise physiology
- Cardiac Structural Anomalies and Repair
- Adipokines, Inflammation, and Metabolic Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nutritional Studies and Diet
- Pancreatic and Hepatic Oncology Research
- Bladder and Urothelial Cancer Treatments
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Physical Activity and Health
- Infective Endocarditis Diagnosis and Management
- Parkinson's Disease Mechanisms and Treatments
- Global Cancer Incidence and Screening
- Spinal Hematomas and Complications
- Venous Thromboembolism Diagnosis and Management
Vanderbilt University
2022-2024
Vanderbilt University Medical Center
2022-2024
Cardiovascular Research Center
2024
University of Washington Medical Center
2022
University of Washington
2020-2022
Washington University in St. Louis
2017-2021
University of Toronto
2019
University of California, Davis
2018
Maine Medical Center
2018
University of Florida
2013-2017
OBJECTIVE—In type 2 diabetes, therapies to maintain blood glucose control usually fail after several years. We estimated the glycemic burden that accumulates from treatment failure and describe time course predictors of failure. RESEARCH DESIGN AND METHODS—A prospective, population-based study using retrospective observational data. identified all 7,208 complete courses with nondrug therapy, sulfonylurea monotherapy, metformin combination oral antihyperglycemic therapy between 1994 2002,...
Patients with recovery of left ventricular ejection fraction (LVEF) remain at risk for future deterioration LVEF. However, there are no tools to stratify these patients. We hypothesized that global longitudinal strain (GLS) could predict sustained within this population.We retrospectively identified 96 patients a reduced LVEF <50% (screening echocardiogram), whose had increased by least 10% and normalized (>50%) on evidence-based medical therapies (baseline echocardiogram). examined absolute...
In Brief Study Design. A multicenter study of prospectively collected pulmonary function testing and radiographic measures in patients surgically treated for adolescent idiopathic scoliosis (AIS). Objective. The objectives this were 1) to identify the factors that determine more than 2 years after surgery AIS; 2) what factors, if any, can predict an increase or decrease percent predicted 2-year function. Summary Background Data. Thoracic spinal deformity lead significant impairment. Studies...
Quantitative interstitial abnormalities (QIAs) are early measures of lung injury automatically detected on chest computed tomography scans. QIAs associated with impaired respiratory health and share features advanced diseases, but their biological underpinnings not well understood.
Abstract Aging is increasingly thought to involve dysregulation of metabolism in multiple organ systems that culminate decreased functional capacity and morbidity. Here, we seek understand complex interactions among metabolism, aging, systems‐wide phenotypes across the lifespan. Among 2469 adults (mean age 74.7 years; 38% Black) Health, Body Composition study identified metabolic cross‐sectionally correlates 20 multi‐dimensional aging‐related spanning seven domains. We used LASSO‐PCA...
BACKGROUND: The biological mechanisms linking environmental exposures with cardiovascular disease pathobiology are incompletely understood. We sought to identify circulating proteomic signatures of and examine their associations cardiometabolic respiratory in observational cohort studies. METHODS: tested the relations >6500 proteins 29 across built environment, green space, air pollution, temperature, social vulnerability indicators ≈3000 participants CARDIA study (Coronary Artery Risk...
INTRODUCTION: More intermuscular fat (IMF) has been associated with lower cognitive performance and faster age-associated decline in function however, the mechanisms driving this relationship have not fully elucidated. We utilized proteomic analyses to identify molecular mediators of association between IMF cognition gain further insight into underlying association. METHODS. In cross-sectional study, plasma profile was assessed Baltimore Longitudinal Study on Aging (BLSA; n=941,...
Current genetic discovery methods are largely restricted to profiling circulating molecules or architecture, limited in use of tissue-based molecular genetics identify pathogenic and therapeutic targets. Here, we leverage a multi-level platform integrating population-level proteomics with functional genomic analyses based on human coronary artery tissue reveal determinants disease susceptibility. Using aptamer-based (~7,000 aptamers) across ~3,000 individuals, first identified the proteome...
Objective The frequency and predictors of improvement in left ventricular ejection fraction (LVEF) ischaemic cardiomyopathy its association with mortality is poorly understood. We sought to assess the LVEF ≥10% effect on mortality. Methods compared characteristics patients enrolled Surgical Treatment for Ischaemic Heart Failure (STICH) trial without at 24 months. A logistic regression model was constructed determine independent improvement. Cox proportional hazards created Results Of 1212...
Abstract Rectus muscle haematoma is a well documented clinical entity, but its diagnosis remains elusive. A within the rectus sheath produces painful, tender swelling that can mimic an intraperitoneal mass with features of acute abdomen. Two patients haematomas presenting after bouts prolonged coughing are reported. In both cases, and ultrasound findings suggested presence pathology. However, in cases consistent history examination pointed towards haematoma. It proposed these simple criteria...
Abstract In this study, we sought to compare protein concentrations obtained from a high‐throughput proteomics platform (Olink) on samples collected using capillary blood self‐collection (with the Tasso+ device) versus standard venipuncture (control). Blood collection was performed 20 volunteers, including one sample via and two device. were stored at 2°C–8°C for 24‐hs (Tasso‐24) or 48‐h (Tasso‐48) prior processing simulate shipping times study participant's home. Proteomics analyzed Olink...
Abstract Despite the wide effects of cardiorespiratory fitness (CRF) on metabolic, cardiovascular, pulmonary and neurological health, challenges in feasibility reproducibility CRF measurements have impeded its use for clinical decision-making. Here we link proteomic profiles to 14,145 individuals across four international cohorts with diverse ascertainment methods establish, validate characterize a score. In cohort around 22,000 UK Biobank, score was associated reduced risk all-cause...
While weight gain is associated with a host of chronic illnesses, efforts in obesity have relied on single "snapshots" body mass index (BMI) to guide genetic and molecular discovery. Here, we study >2,000 young adults metabolomics proteomics identify metabolic liability early adulthood. Using longitudinal regression penalized regression, signature for liability, 2.6% (2.0%–3.2%, p = 7.5 × 10−19) BMI over ≈20 years per SD higher score, after comprehensive adjustment. Identified molecules...
Greater left ventricular (LV) wall stress is associated with adverse outcomes among patients prevalent heart failure (HF). Less known about the association between LV and incident HF.
Abstract Context Prior studies of the relationship between physical activity and incident type 2 diabetes mellitus (T2DM) relied primarily on questionnaires at a single time point. Objective We sought to investigate T2DM with an innovative approach using data from commercial wearable devices linked electronic health records in real-world population. Methods Using All Us participants’ accelerometer their personal Fitbit devices, we used time-varying Cox proportional hazards models repeated...
Abstract Objective Weight regain occurs after medical weight loss via mechanisms of post‐weight‐loss “metabolic adaptation.” The relationship inflammatory proteins with loss/regain was studied to determine a role for inflammation in metabolic adaptation. Methods Seventy‐four central and immune regulation (Olink) were analyzed plasma from up 490 participants trial weight‐loss maintenance. Cross‐sectional longitudinal associations measured using linear mixed effects regression models t...