A5100718392- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Respiratory viral infections research
- Immune Response and Inflammation
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Intracerebral and Subarachnoid Hemorrhage Research
- Polysaccharides and Plant Cell Walls
- Genomics and Phylogenetic Studies
- Neurogenesis and neuroplasticity mechanisms
- Genetic Neurodegenerative Diseases
- Memory and Neural Mechanisms
- RNA Research and Splicing
- Gene Regulatory Network Analysis
- Brain Metastases and Treatment
- Uterine Myomas and Treatments
- Advanced Chemical Sensor Technologies
- Ion channel regulation and function
- Influenza Virus Research Studies
- Plant-Derived Bioactive Compounds
- Inflammation biomarkers and pathways
- Acute Ischemic Stroke Management
- Infection Control and Ventilation
Wright State University
2023-2025
Northwestern University
2020-2024
Shandong Academy of Agricultural Sciences
2018-2024
Chinese PLA General Hospital
2021-2022
The Seventh Affiliated Hospital of Sun Yat-sen University
2020
Sun Yat-sen University
2020
University of Kansas
2007-2018
Jiangsu University of Science and Technology
2015
Hunan Normal University
2015
Nanjing Medical University
2014
Oxidative stress (OS), caused by the imbalance between generation and detoxification of reactive oxygen nitrogen species (ROS/RNS), plays an important role in brain aging, neurodegenerative diseases, other related adverse conditions, such as ischemia. While ROS/RNS serve signaling molecules at physiological levels, excessive amount these leads to oxidative modification and, therefore, dysfunction proteins, nucleic acids, lipids. The response neurons this pervasive stress, however, is not...
Although the roles of metabolic stress in organ ischemia-reperfusion injury (IRI) have been well recognized, question whether and how these responses regulate innate immune activation against IR remains unclear. In a murine liver partial warm ischemia mode, we showed that prolonged triggered endoplasmic reticulum (ER) response, particularly, activating transcription factor 6 (ATF6) branch, Kupffer cells (KCs) altered their responsiveness Toll-like receptor (TLR) stimulation. Ischemia-primed...
Background The current study aimed to evaluate the relationship between neutrophil-to-lymphocyte ratio (NLR) combined with interleukin (IL)-6 on admission day and 28-day mortality of septic patients. Material Methods We conducted an observational retrospective study. Patients presumed sepsis were included. observed correlation studied biomarkers (NLR, IL-6, PCT, CRP) severity scores (APACHE II SOFA scores) by plotting scatter plots. relationships evaluated using Cox regression model,...
Pivotal brain functions, such as neurotransmission, cognition, and memory, decline with advancing age and, especially, in neurodegenerative conditions associated aging, Alzheimer's disease (AD). Yet, deterioration structure function of the nervous system during aging or AD is not uniform throughout brain. Selective neuronal vulnerability (SNV) a general but sometimes overlooked characteristic AD. There little known at molecular level to account for phenomenon SNV. Functional genomic...
In our ongoing search toward identifying novel and synthetically simpler candidate vaccine adjuvants, we hypothesized that the imidazo[1,2-a]pyrazines, readily accessible via Groebke–Blackburn–Bienaymé multicomponent reaction, would possess sufficient structural similarity with TLR7/8-agonistic imidazoquinolines. With pyridoxal as aldehyde component, furo[2,3-c]pyridines, rather than expected imidazo[1,2-a]pyridines, were obtained, which characterized by NMR spectroscopy crystallography....
Abstract Motivation: Bayesian network methods have shown promise in gene regulatory reconstruction because of their capability capturing causal relationships between genes and handling data with noises found biological experiments. The problem learning structures, however, is NP hard. Consequently, heuristic such as hill climbing are used for structure learning. For networks a moderate size, not computationally efficient. Furthermore, relatively low accuracy the learned structures may be...
Oxidative stress (OS) is an important factor in brain aging and neurodegenerative diseases. Certain neurons different regions exhibit selective vulnerability to OS. Currently little known about the underlying mechanisms of this neuronal vulnerability. The purpose study was identify endogenous factors that predispose vulnerable OS by employing genomic biochemical approaches.In report, using vitro cultures, ex vivo organotypic slice cultures acute preparations, we established cerebellar...
The effects of lifelong, moderate excess release glutamate (Glu) in the CNS have not been previously characterized. We created a transgenic (Tg) mouse model lifelong synaptic Glu by introducing gene for dehydrogenase 1 (Glud1) under control neuron-specific enolase promoter. Glud1 is, potentially, an important enzyme pathway synthesis nerve terminals. Increased levels GLUD protein and activity neurons hemizygous Tg mice were associated with increases vivo after neuronal depolarization...
• Genomic assay of sperm cell RNA provides insight into functional control, modes regulation, and contributions male gametes to double fertilization. Sperm cells rice (Oryza sativa) were isolated from field-grown, disease-free plants was processed for use with the full-genome Affymetrix microarray. Comparison Gene Expression Omnibus (GEO) reference arrays confirmed expressionally distinct gene profiles. A total 10 732 sequences detected in cells, which 1668 not expressed pollen or seedlings....
Toll-like receptor (TLR)-8 agonists activate adaptive immune responses by inducing robust production of T helper 1-polarizing cytokines, suggesting that TLR8-active compounds may be promising candidate adjuvants. We synthesized and evaluated hitherto unexplored furo[2,3-c]quinolines regioisomeric furo[3,2-c]quinolines derived via a tandem, one-pot Sonogashira coupling intramolecular 5-endo-dig cyclization strategy in panel primary screens. observed pure TLR8-agonistic activity profile select...
The 2021 WHO Classification of Tumors the Central Nervous System includes several tumor types and subtypes for which diagnosis is at least partially reliant on utilization whole genome methylation profiling. current approach to array DNA profiling utilizes a reference library data, machine learning-based classifier. This was pioneered popularized by German Cancer Research Network (DKFZ) University Hospital Heidelberg. research group has kindly made their classifier central nervous system...
Femoral atherosclerotic plaques are less inflammatory than carotid histologically, but limited cell-level data exist regarding comparative immune landscapes and polarization at these sites. We investigated intraplaque leukocyte phenotypes transcriptional in 49 patients undergoing femoral (n = 23) or 26) endarterectomy using single-cell RNA-Seq (scRNA-Seq; n 13), flow cytometry 24), IHC 12). Comparative scRNA-Seq of CD45+-selected leukocytes from 9; 35,265 cells) 4; 30,655 plaque revealed...
The neuromuscular junction (NMJ) is the linchpin of nerve-evoked muscle contraction. Broadly, function NMJ to transduce nerve action potentials into fiber (MFAPs). Efficient transmission requires both cholinergic signaling, responsible for generation endplate (EPPs), and excitation, amplification EPP by postsynaptic voltage-gated sodium channels (Nav1.4) generate MFAP. In contrast component, signaling pathways that organize Nav1.4 mediate excitability are poorly characterized....
As a new strain of virus emerged in 2013, avian influenza A (H7N9) is threat to the public health, due its high lethality and pathogenicity. Furthermore, H7N9 has already generated various mutations such as neuraminidase R294K mutation which could make anti-influenza oseltamivir less effective or ineffective. In this regard, it urgent develop anti-H7N9 drug. study, we used general oseltamivir-resistant acceptors employed small molecules including quercetin, chlorogenic acid, baicalein,...
There is a pressing need for the development of novel, safe, and effective adjuvants. The recent discovery characterization pathogen-associated molecular pattern (PAMP)-recognizing elements such as Toll-like, NOD-like, RIG-like receptors, has brought into sharp focus role PAMPs in bridging innate adaptive immune responses, detailed understanding immunostimulatory vis-à-vis proinflammatory activities could lead to adjuvants, monophosphoryl lipid A being an excellent example. We describe this...
The liver- and intestine-enriched carboxylesterase 2 (CES2) enzyme catalyzes the hydrolysis of several clinically important anticancer agents administered as prodrugs. For example, irinotecan, a carbamate prodrug used in treatment colorectal cancer, is biotransformed vivo by CES2 intestine liver, thereby producing potent topoisomerase I inhibitor. Pregnane X receptor (PXR) constitutive androstane (CAR), two members nuclear superfamily ligand-activated transcription factors, mediate gene...
Increases during aging in extracellular levels of glutamate (Glu), the major excitatory neurotransmitter brain, may be linked to chronic neurodegenerative diseases. Little is known about molecular responses neurons chronic, moderate increases Glu levels. Genome-wide gene expression brain hippocampus was examined a unique transgenic (Tg) mouse model that exhibits hyperactivity throughout lifespan, neuronal Glutamate dehydrogenase (Glud1) mouse, and littermate 9 month-old wild type mice....
N-Acyl-γ-glutamyldiaminopimelic acid is a prototype ligand for Nod1. We report detailed SAR of C12-γ-d-Glu-DAP. Analogues with glutaric or γ-aminobutyric replacing the glutamic show greatly attenuated Nod1-agonistic activity. Substitution meso-diaminopimelic (DAP) component monoaminopimelic acid, l- d-lysine, cadaverine also results in reduced The free amine on DAP crucial. However, N-acyl group d-glutamyl residue can be substituted N-alkyl groups full preservation carboxylates and Glu...
Peptidoglycan recognition protein (PGRP) binds specifically to peptidoglycan and plays an important role as a pattern receptor in the innate immunity of insects. The cDNA short-type PGRP, open reading frame 588 bp encoding polypeptide 196 amino acids, was cloned from Bombyx mori . A phylogenetic tree constructed, results showed that BmPGRP-S2 most similar Drosophila melanogaster PGRP ( DmPGRP-SA ). induced expression profile healthy Escherichia coli - Bacillus subtilis- challenged B....
Lin28 is a family of RNA binding proteins and microRNA regulators. Two members this have been identified: Lin28A Lin28B, which are encoded by genes localized in different chromosomes but share high degree sequence identity. The role Lin28B androgen-independent prostate cancer (AIPC) not well understood. expressed all grades prostatic carcinomas cell lines, normal tissue. In study we found that co-localized the nucleus cytoplasm DU145 AIPC. expression protein positively correlated with c-Myc...