A5062136733- Muscle Physiology and Disorders
- Ion channel regulation and function
- Muscle activation and electromyography studies
- Cardiomyopathy and Myosin Studies
- Genetic Neurodegenerative Diseases
- Neurogenetic and Muscular Disorders Research
John Brown University
2023-2025
Brown University
2022
The neuromuscular junction (NMJ) is the linchpin of nerve-evoked muscle contraction. Broadly, function NMJ to transduce nerve action potentials into fiber (MFAPs). Efficient transmission requires both cholinergic signaling, responsible for generation endplate (EPPs), and excitation, amplification EPP by postsynaptic voltage-gated sodium channels (Nav1.4) generate MFAP. In contrast component, signaling pathways that organize Nav1.4 mediate excitability are poorly characterized....
The neuromuscular junction (NMJ) is the linchpin of nerve-evoked muscle contraction. Broadly considered, function NMJ to transduce a nerve action potential into fiber (MFAP). Efficient information transfer requires both cholinergic signaling, responsible for generation endplate potentials (EPPs), and excitation, activation postsynaptic voltage-gated sodium channels (Nav1.4) trigger MFAPs. In contrast apparatus, signaling pathways that organize Nav1.4 excitability are poorly characterized....
ABSTRACT Myofiber size regulation is critical in health, disease, and aging. MuSK (muscle-specific kinase) a BMP (bone morphogenetic protein) co-receptor that promotes shapes signaling. expressed at all neuromuscular junctions also present extrasynaptically the slow soleus muscle. To investigate role of MuSK-BMP pathway vivo we generated mice lacking BMP-binding Ig3 domain. These ΔIg3-MuSK are viable fertile with innervation levels comparable to wild type. In 3-month-old myofibers smaller...