A5074794766- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Parathyroid Disorders and Treatments
- Pulmonary Hypertension Research and Treatments
- Heart Failure Treatment and Management
- Medical Imaging and Pathology Studies
- Coronary Artery Anomalies
- Long-Term Effects of COVID-19
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Aortic Disease and Treatment Approaches
- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Infective Endocarditis Diagnosis and Management
- Hemodynamic Monitoring and Therapy
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiomyopathy and Myosin Studies
- Sleep and related disorders
- Viral Infections and Immunology Research
- Mechanical Circulatory Support Devices
- Cardiovascular Effects of Exercise
Northwestern University
2022-2025
Prince Charles Hospital
2020-2025
Cardiovascular Institute of the South
2022-2024
The University of Queensland
2014-2024
Northwestern Memorial Hospital
2023-2024
Prince Charles Hospital
2021-2024
Northwestern University
2023
Mater Research
2021
Royal Brisbane and Women's Hospital
2020
Queensland Health
2016-2020
Four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) shows promise for quantifying mitral regurgitation (MR) by allowing direct regurgitant volume (RVol) measurement using a plane precisely placed at the MR jet. However, ideal location of remains unclear. This study aims to systematically examine how varying locations affect RVol quantification and determine optimal momentum conservation principle free Patients diagnosed with transthoracic echocardiography (TTE) scheduled CMR...
Abstract Aims Differentiating cardiac amyloidosis (CA) subtypes is important considering the significantly different therapies for transthyretin (ATTR)-CA and light chain (AL)-CA. Therefore, an echocardiographic method to distinguish ATTR-CA from AL-CA would provide significant value. We assessed a novel pixel intensity quantify myocardial calcification differentiate phenocopies of CA AL-CA, specifically. Methods results 167 patients with (n = 53), 32), hypertrophic cardiomyopathy 37),...
Abstract Loss of circadian rhythms and reduced concentrations endogenous melatonin are common in critically ill patients. After exogenous administration, supra-physiological serum only ephemeral, which may explain the absence significant therapeutic effect on sleep. The aim this study is to describe pharmacokinetics enteral patients administered a novel regimen aiming simulate release. Thirteen recovery phase critical illness were randomised receive or placebo. In group, total 6 mg was as...
Sleep deprivation is a contributor for delirium in intensive care. Melatonin has been proposed as pharmacological strategy to improve sleep, but studies have shown that the increase plasma levels of melatonin do not correlate beneficial clinical effect; addition, melatonin's short half-life may be major limitation achieving therapeutic levels. This study applies previously published novel regimen with proven sustained during 12 h period. In this study, aim determine if such dosing positively...
Abstract Background The influence of renin–angiotensin–aldosterone system (RAAS) inhibitors on the critically ill COVID-19 patients with pre-existing hypertension remains uncertain. This study examined impact previous use angiotensin-converting enzyme (ACEi) and angiotensin receptor blockers (ARB) patients. Methods Data from an international, prospective, observational cohort involving 354 hospitals spanning 54 countries were included. A 737 admitted to intensive care units (ICUs) in 2020...
Left atrial analysis is employed in diastolic assessment with left volume index (LAVI) incorporated the 2016 ASE/EACVI diastology guideline algorithm. LAVI has sub-optimal correlation invasive ventricular filling pressure (LVFP) and incorporation of reservoir strain (LASr) may improve assessment.A cross-sectional prospective study 139 patients was undertaken all undergoing transthoracic echocardiography immediately prior to cardiac catheterization evaluation LVFP. LASr by speckle tracking...
Heart failure within the adult congenital heart disease (ACHD) population is a significant source of morbidity and mortality. Optimal medical therapy (OMT) remains mainstay management for ACHD patients. Sacubitril/Valsartan an angiotensin-receptor neprilysin inhibitor (ARNI) which relatively novel addition to pantheon therapies with evidence base support its reduction in rehospitalisation, improvement ventricular reverse remodelling mortality general population. Its use limited small case...
This study sought to determine the contractile reserve (CR) response exercise stress echocardiography (ESE) quantified by novel parameter, non-invasive myocardial work (MW), in subjects with angiographically proven coronary artery disease (CAD).CR was measured relative change ejection fraction (EF), global longitudinal strain (GLS) and MW indices from rest peak 304 patients referred for clinically indicated ESE. Positive ESE proceeded angiography further risk stratified based on either...
Abstract Aims The availability of a true 3D dataset provides an opportunity for automation left ventricular (LV) and atrial (LA) measurements. Although manual automated measurements volumes are known to correlate, the variance is important parameter individual patient. reasons discrepancies remain unexplained. We hence aim explain disagreement between LV LA volumes. Methods Results A total 355 patients underwent standard clinical echo, with offline analysis in both fully‐ (Heart Model,...