A5045856368- Melanoma and MAPK Pathways
- Lung Cancer Treatments and Mutations
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Cancer Genomics and Diagnostics
- Ethics in Clinical Research
- Colorectal Cancer Treatments and Studies
- Biomedical Ethics and Regulation
- Global Cancer Incidence and Screening
- Cancer Mechanisms and Therapy
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- COVID-19 and healthcare impacts
- Synthesis and biological activity
- Breast Implant and Reconstruction
- Immune cells in cancer
- Innovations in Medical Education
- Artificial Intelligence in Healthcare and Education
- Economic and Financial Impacts of Cancer
- Liver physiology and pathology
- Radiomics and Machine Learning in Medical Imaging
- Acute Ischemic Stroke Management
- Advanced Breast Cancer Therapies
- Monoclonal and Polyclonal Antibodies Research
- Grief, Bereavement, and Mental Health
The University of Texas at Austin
2020-2024
Northwestern University
2012-2024
Indian Institute of Public Health Gandhinagar
2023
SRM Institute of Science and Technology
2022
Georgetown University
2022
It is well established that activation of the transcription factor signal transducer and activator 1 (STAT1) required for interferon-γ (IFN-γ)-mediated antiviral response. Here, we found IFN-γ receptor stimulation also activated Unc-51-like kinase (ULK1), an initiator Beclin-1-mediated autophagy. Furthermore, interaction between ULK1 mitogen-activated protein MLK3 (mixed lineage 3) was necessary phosphorylation downstream ERK5. This autophagy-independent activity promoted key IFN-stimulated...
We are interested in the kind of well-being that can occur as a person approaches death; we call it “existential maturity.” describe conceptual model this state felt was realized an individual case, illustrating by describing case. Our goal is to articulate generalizable, working existential maturity concepts and terms taken from fundamentals psychodynamic theory. hope recognizable case model-based way thinking about what going on both help guide care fosters stimulate more theoretical...
PURPOSE Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. Social media platforms such as Twitter are extensively used to communicate about care, yet little known role these online in promoting early detection or sharing lived experiences patients with CRC. This study tracked discussions CRC and characterized participating users better understand public communication perceptions during COVID-19 pandemic. METHODS Tweets containing references were...
Background: Breast cancer in developing countries is on the rise. There are currently no guidelines to screen women at risk India. Since mammography western world a well-accepted screening tool prevent late presentation of breast and improve mortality, it intuitive adopt as choice. However, expensive fraught with logistical issues like Materials Methods: Our camp was done local district hospital India after approval from director administrators. After initial training health care workers,...
The identification of BRAF V600 mutation in multiple cancers beyond melanoma and the development combined MEK targeting agents have altered landscape tissue-agnostic precision oncology therapies with an impact on survival outcomes. Despite initial efficacy, resistance emerges, it is pertinent to identify putative mechanisms. We report a case recurrent glioblastoma (GBM) harboring V600E alteration who initially responded + inhibition subsequently developed treatment by histological...
The Telangana cancer care program is a proactive, comprehensive initiative encompassing infrastructure development, human resource skilling and ensuring financial protection to those below poverty line. broad aim of this exercise was identify modalities augment the State Cancer Control Plan implement sustainable model for Telangana.We conducted in-depth interviews stakeholders (17 patients 25 health providers) barriers challenges access existing system in Telangana; calculated magnitude...
Abstract: Conversational toxicity is a problem that might drive people to cease truly expressing themselves and seeking out other people's opinions of fear being attacked or harassed. The purpose this research employ natural language processing (NLP) techniques detect in writing, which be used alert before transmitting potentially toxic informational messages. Natural part machine learning enables computers comprehend language. Understanding, analysing, manipulating, maybe producing human...
e13748 Background: Overcoming disparities in cancer research is a major challenge that needs to be prioritized clinical trials oncology. In this study, we aimed assess the current representation of patient demographics phase 2 and 3 oncology illuminate healthcare inequities during trial recruitment. Methods: We identified published studies five medical journals (New England Journal Medicine, Clinical Oncology, Lancet, Lancet JAMA Oncology). extracted data on including sex, age, race,...
3112 Background: The advent of tyrosine kinase inhibitors (TKIs) has altered the therapeutic landscape multiple hematological and solid malignancies. FDA approved starting doses TKIs are based on recommended phase 2 dose (RP2D) in clinical trials. Since many these drugs continuously dosed, ongoing toxicities may lead to drug reductions discontinuations. Hence practice, patients started lower due tolerability concerns or dose-reduced subsequently for toxicity. Herein, we assessed dosing,...
Under optimal physiologic conditions, liver resident macrophages, such as Kupffer cells, are abundant in maintaining homeostasis. They orchestrate postinjury inflammatory tissue remodeling, surveil malignant microbial organisms, and remove toxins. Nevertheless, during chronic inflammation wound healing the liver, hepatic infiltration of immune cells from bone marrow, peritoneum, lymph nodes can promote maintenance macrophages subsets that exacerbate injury. Depending on span extent damage,...
e18504 Background: There has been exponential economic growth in the BRIC (Brazil, Russia, India and China) nations recent years, outsourcing of clinical trials to these countries occurred tandem. Our study aimed assess current status early phase oncology trial recruitment countries, impact emerging economies global markets health care. Methods: We reviewed open-access registry, clinicaltrials.gov, for registered interventional recruiting (Phase I/II) adults analyzed each country separately...
By Neha K. Reddy, Clark Andersen & 2 more. In this study, we show that in studies on approved tyrosine kinase inhibitors black and hispanic races are consistently underrepresented. To address disparities, future should then broaden their populations
Abstract Background: Although the survival rates for breast cancer have improved, there is still a disparity gap between Hispanic women and non-Hispanic women. in US are vulnerable to inequalities due plethora of barriers including disproportionate poverty, lack health insurance, citizenship status. A Surveillance, Epidemiology, End Results analysis found that had lower both early-stage receipts radiation therapy (RT) after breast-conserving surgery than White For patients without private or...
Supplementary Figure from Tissue-Agnostic Activity of BRAF plus MEK Inhibitor in V600–Mutant Tumors
<div>Abstract<p>BRAF plus MEK inhibitor combinations are currently FDA-approved for melanoma, non–small cell lung cancer, and anaplastic thyroid cancer. The lack of clinical benefit with BRAF inhibition in V600–mutated colorectal cancer has prevented its tissue-agnostic drug development. We reviewed the AACR GENIE database prevalence V600 mutations across tumor types. literature case reports responses, outcomes patients mutation—positive nonmelanoma malignancies who received...