A5100608263- Ureteral procedures and complications
- Gut microbiota and health
- Diet and metabolism studies
- Pediatric Urology and Nephrology Studies
- Kidney Stones and Urolithiasis Treatments
- Urological Disorders and Treatments
- Phytoestrogen effects and research
- Metabolomics and Mass Spectrometry Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Autophagy in Disease and Therapy
- Renal and Vascular Pathologies
- Growth Hormone and Insulin-like Growth Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Sperm and Testicular Function
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Screening and Detection
- Endometriosis Research and Treatment
- Bee Products Chemical Analysis
- Pelvic and Acetabular Injuries
- GDF15 and Related Biomarkers
- Intraocular Surgery and Lenses
- Adipose Tissue and Metabolism
- Cancer Risks and Factors
- Nutritional Studies and Diet
Huashan Hospital
2011-2023
Fudan University
2014-2023
We have previously demonstrated abnormal gut microbial composition in castration-resistant prostate cancer (CRPC) patients, here we revealed the mechanism of microbiota-derived short-chain fatty acids (SCFAs) as a mediator linking CRPC microbiota dysbiosis and (PCa) progression. By using transgenic TRAMP mouse model, PCa patient samples, vitro cell transwell macrophage recruitment assays, examined effects fecal transplantation (FMT) SCFAs on Our results showed that FMT with patients'...
Gut microbiota dysbiosis is related to cancer development and progression. Our previous study showed that Ruminococcus was more abundant in CRPC (Castration-resistant prostate cancer) than HSPC (Hormone-sensitive individuals. Here, we determined the potential mechanism of (PCa) Metagenomics used verify gut microbial discrepancies between Fecal transplantation (FMT) performed by transferring fecal suspension or individuals TRAMP mice. Afterwards, mice’s histopathology composition were...
Purpose: We evaluated the effectiveness and safety of holmium: YAG laser lithotripsy with a semirigid ureteroscope for ureteral calculi in prospective cohort 697 patients. Patients Methods: Holmium: was performed inpatients between September 2002 January 2006. Calculi were located distal ureter 382 patients (54.8%), midureter 143 (20.5%), proximal 172 (24.7%). assessed 2 to 24 weeks postoperatively repeat plain radiography, ultrasonography, intravenous urography, or some combination....
Background Long term dietary consumption of genistein by Chinese men is associated with decreased PCa metastasis and mortality. Short treatment US prostate cancer (PCa) decreases MMP-2 in tissue. MEK4 regulates expression, drives metastasis, inhibits MEK4, expression dosing human mice. This study examines short- versus long-term effects humans vitro. Methods findings localized were treated on a phase II trial (N = 14) not for one month prior to radical prostatectomy. Prostate epithelial...
It is known that gut microbiota can regulate cancer therapies. We hypothesized may interact with androgen deprivation therapy (ADT) in the process of castration-resistant prostate (CRPC). Here, differences between matched hormone-sensitive (HSPC) and CRPC were determined before after ADT.We profiled fecal HSPC from 21 patients who received ADT at our urological center using 16S rRNA gene amplicon sequencing. Differences α/β-diversity LefSe analysis. Functional inference was performed...
Genistein is one of the main soy isoflavones in our daily diet. There were studies proving that high-dietary intake genistein may relate to low morbidity and mortality prostate cancer (PCa) Asian population. Since there few plasma level Chinese population, we performed this study preliminarily evaluate associations among genistein, epidemiologic factors PCa a Between 2012 2013, 100 men over age 40 underwent biopsy for at Huashan Hospital, Shanghai, China. Clinical information, information...
Consumption of diet high in soy products is suggested to contribute lower prostate cancer incidence Asian men. But little has been known about the influences dietary patterns on gut microbiota and microbiota-mediated isoflavone metabolism. Here, we determined western pattern carcinogenesis, equol metabolism using a transgenic adenocarcinoma mouse (TRAMP) model. We mimicked fat (HFD). TRAMP mice were fed with either control (CD) or HFD. At age 24 weeks, orally administered daidzein over 4-day...
To investigate the common etiologies, characteristics, and management of ureteric injury.A nationwide study was performed in 38 medical centers from Mar 2017 to 2019. The data patients with injury were retrospectively collected.Overall, 294 included this study. Ten cases (3.4%) due abdominal injuries, 284 (96.6%) iatrogenic including 48.6% urological procedures, 41.9% gynecological 6.3% general surgery, 3.2% other treatments. Most injuries (79.7%) caused by endourological procedures. Injury...
// Yufei Liu 1, 2, * , Zhebin Du 3, Jin Zhang 3 Haowen Jiang 2 1 Department of Urology, Huashan Hospital, Fudan University, Shanghai, China Institute Ren Ji School Medicine, Shanghai Jiao Tong These authors contributed equally to this work Correspondence to: Jiang, email: oncouro_jhw@126.com Zhang, med-zhangjin@vip.sina.com Keywords: Raman spectroscopy, renal tumor, biopsy, non-invasive, pre-operative diagnosis Received: October 06, 2016 Accepted: March 10,...
We aim to investigate the impact of maternal high fat diet (HFD) on development and progression prostate cancer (PCa) in transgenic adenocarcinoma mouse (TRAMP) offspring.The TRAMP model was used, divided into HFD group normal (ND) present study. Each contained 36 mice. Serum levels leptin, adiponectin, interleukin (IL) -1α, IL-1β, IL-6, tumor necrosis factor-α monocyte chemotactic protein-1 were measured by 20th, 24th 28th week old through ProcartaPlex Multiplex Immunoassay. Body ratio...
Estrogen may help to preserve renal function in chronic kidney disease. This study examined whether estrogen administration or deprivation affected the split rats subjected unilateral ureteral obstruction (UUO). Fifteen adult female Sprague-Dawley were randomly divided into three groups. Low- and high-estrogen groups modeled by castration intraperitoneal injection, respectively, normal-estrogen group untreated. Intermittent [glomerular filtration rate (GFR)] examination was performed on days...
We investigated the effectiveness of NTrap in prevention stone retropulsion during ureteroscopic Ho:YAG laser lithotripsy upper ureteral calculi. A total 308 patients with stones treated by semirigid were stratified into two groups which 152 without use assigned to Group I and 156 II. Patient gender, age, size, operative time, parameters for migration compared between groups. The difference patient size insignificant Longer duration (P = 0.000) was observed II showed a higher intraoperative...
To evaluate the effectiveness and safety of holmium:YAG (Ho:YAG) laser endopyelotomy in distinctive ureteropelvic junction obstructions (UPJO) with aetiologies.Thirty-one patients diagnosed UPJO causes were included. Aetiology consisted 7 congenital UPJO, 10 post-pyeloplasty post-lithotomy obstructions, 4 post-extracorporeal shockwave lithotripsy stenoses 3 post-ureteroscopic lithotriptic UPJO. Retrograde ureteroscopic Ho:YAG was performed all patients. Operation related parameters...
Background High fat diet (HFD) and its responsive change of gut microbiota are associated with numerous diseases in human animal studies. But how maternal post‐weaning HFD may influence the tumorigenesis prostate cancer (PCa) male offspring has not yet been reported. Methods We studied both solitary combined effects or/and on using a transgenic adenocarcinoma mouse (TRAMP) model. TRAMP mice ( n = 24) were born to fostered onto control or HFD‐fed mothers, weaned pups further fed diet. All...
Background: Gut microbiota dysbiosis is closely related to cancer development and progression. Our previous study showed that Ruminococcus was more abundant in CRPC relative HSPC individuals. Here, we sought determine the potential mechanism of prostate (PCa) progression.Methods: Metagenomics used gut microbial discrepancies between Fecal transplantation (FMT) performed by transferring fecal suspension or individuals TRAMP mice. Afterwards, mice’s histopathology composition were determined....
Emerging evidence indicates that aldosterone and mineralocorticoid receptors (MRs) are associated with the pathogenesis of erectile dysfunction. However, molecular mechanisms remain largely unknown. In this study, freshly isolated penile corpus cavernosum tissue from rats was treated aldosterone, or without MRs inhibitors. Nuclear factor (NF)-kappa B (NF-κB) activity evaluated by real-time quantitative PCR, luciferase assay, immunoblot. The results demonstrated mRNA levels NF-κB target...
Objective: To evaluate the efficacy of Holmium: YAG laser lithotripsy for ureteral steinstrasse after extracorporeal shock (SWL). Material and methods: was performed on 21 patients who had developed post-SWL. Results: Nineteen cases successful treatment. The cleared within one month treatment (success rate 90.48%). Upper shifted to renal pelvis noted in patient, underwent a second SWL Another patient severely kinking ureter open surgery ureteroscopy failed. Conclusion: post-SWL is an...
Reconstruction of ureteral defects and strictures remains problematic for urologists. We aimed to investigate the possibility a tapered non-vascularized bladder graft as novel substitute reconstruction.This experimental study was conducted on nine beagles. Under general anesthesia, full-thickness with 5-6 cm in length disassociated from anterior upper wall bladder, into 1/3 1/2 thickness, remaining urothelial surface. After removal 5 right-sided mid-ureter, tubularized along long axis then...
High-fat diet induced obesity was associated with more aggressive prostate cancer. Recent research has demonstrated that integrin-linked kinase (ILK), β-parvin and downstream cofilin 1 jointly affected cancer progression. Meanwhile, these proteins were also involved in energy metabolism. Therefore, the present study conducted to investigate potential function of ILK, high-fat diet-induced progression Transgenic mice employed, fed different diets sacrificed at 20 28 weeks. Tumor...