A5101059466- Renal cell carcinoma treatment
- Renal and related cancers
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Inflammatory mediators and NSAID effects
- Spanish Linguistics and Language Studies
- Adrenal and Paraganglionic Tumors
- Scarabaeidae Beetle Taxonomy and Biogeography
- Urinary and Genital Oncology Studies
- Pediatric Urology and Nephrology Studies
- Retinoids in leukemia and cellular processes
- Coleoptera: Cerambycidae studies
- DNA Repair Mechanisms
- Angiogenesis and VEGF in Cancer
- Kidney Stones and Urolithiasis Treatments
- Cancer, Lipids, and Metabolism
- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Mediterranean and Iberian flora and fauna
- Thyroid Cancer Diagnosis and Treatment
Mianyang Normal University
2024
Union Hospital
2024
Huazhong University of Science and Technology
2014-2024
Fudan University
2012-2023
Yulin University
2023
Huashan Hospital
2010-2023
Yibin University
2023
He Eye Hospital
2018
Obstetrics and Gynecology Hospital of Fudan University
2018
Abstract We aimed to exploit novel compounds with high selectivity clear cell renal carcinoma (ccRCC) common mutations. Using the GDSC databases, we searched for ccRCC VHL and/or SETD2 Clinical impact and gene interactions were analysed using TCGA database. In vitro in vivo studies performed validate inhibitory effects of compound. identified selective PI3Kβ inhibitor TGX221 as a both also targeted cancer cells CDKN2A PTEN Changes sets associated worsened prognosis ccRCC. substantially...
Kinases play critical role in clear-cell renal cell carcinoma (ccRCC). We aim to exploit novel kinase that is both protumorigenic and drugable ccRCC.
Aim: Sunitinib remains the frontline treatment for metastatic clear-cell renal cell carcinoma (ccRCC).Drug resistance is inevitable and related mechanism warrant insightful elaboration.Methods: In silico data mining of GEO TCGA datasets was performed to identify potential target micro-RNA.In vitro in vivo studies were validate findings.Results: Reproduction revealed miR-15b significantly upregulated sunitinibresistant ccRCC.Five out seven ccRCC lines demonstrated overexpressed after...
Renal clear cell carcinoma (ccRCC) is characterized by frequent mutation in SETD2, which has recently been shown to regulate mismatch repair (MMR). We aim investigate the association between MMR machinery genes and SETD2 ccRCC. exploited Genomics of Drug Sensitivity Cancer (GDSC) database identify selective inhibitors for mutant ccRCC cells. also Genome Atlas (TCGA) study status MMR-related genes. In vitro studies were performed validate silico findings. Reproduction GDSC revealed four...
Early detection is the key to improve prognosis of kidney cancer. This study profiled and identified differentially expressed serum proteins in stage T1a renal cell carcinoma (RCC) using isobaric tags for relative absolute quantification (iTRAQ)-based mass spectrometry. A total amount 99 samples including 29 patients with ccRCC, 24 a benign mass, 28 another type urological tumor (20 cases transitional 8 prostate cancer or male genital tumor), 18 healthy controls were subjected iTRAQ-based...
Aim The action of immune checkpoint inhibition (ICI) largely depends on antibody-dependent cellular phagocytosis (ADCP). We thus aim to develop ADCP-based ccRCC risk stratification as both prognostic and therapeutic markers ICI. Method Genomic data from multiple public datasets (TCGA, etc.) were integrated. A cancer-intrinsic ADCP gene set for tailored a recent report was constructed based the association with prognosis, infiltrates, response Therapeutic potential profiled using genome-drug...
In order to investigate the two members of EF‑hand Ca2+ binding protein S100 family, S100A8 and S100A9, in renal cell carcinoma (RCC), serum samples were collected from patients with RCC, transitional kidney, benign masses normal controls. The analyzed by isobaric tags for relative absolute quantification technology identify differential expression S100A9 respective groups. Hierarchical clustering analysis was then conducted relevant selected gene. cross‑platform external validation...
Abstract Notch signaling was associated with a variety of cancers but not comprehensively studied in clear‐cell renal cell carcinoma (ccRCC). We have this study the genetic alteration (mutation and copy number variance) gene set Cancer Genome Atlas (TCGA) Kidney Renal Clear Cell Carcinoma (KIRC) database. found that pathway frequently altered ccRCC. The genetically 182 (44%) 415 ccRCC patients. CNV predominant type most genes. Alterations KAT2B MAML1 occurred 13% 19% patients, respectively,...
Abstract Adrenocortical carcinoma (ACC) is a rare malignancy, and CTNNB1 frequently mutated in ACC. Our study aims to screen for effective agents with antineoplastic activity against ACC mutation. In‐silico screening of the Genomics Drug Sensitivity Cancer (GDSC) database was conducted. sensitivity cells mutation analyzed further vitro vivo studies were performed using compound. Only one compound, Nutlin‐3a, an MDM2 inhibitor, significantly sensitive 18 cancer Further analysis revealed no...
Human epidermal growth factor receptor type 2 (HER2) and androgen (AR) are critical factors for prostate cancer (PCa) progression. These regulate tumor cell survival proliferation, remain as crucial drivers of castration-resistant PCa Icaritin (ICT) is a prenyl flavonoid derived from the Epimedium genus, which has many biological pharmacological effects. Using androgen-sensitive human carcinoma LNCaP lines, we found that 35 μg/ml ICT could inhibit more than 50% induce apoptosis, lead to...
Osteoprotegerin (OPG) is a soluble decoy receptor for activator of nuclear factor kB ligand (RANKL), and implicated in the pathogenesis atherosclerosis. The aim present study was to examine hypothesis that serum OPG concentrations are increased patients with stable coronary artery disease (CAD) at different levels RANKL (sRANKL). used case‑control design which consecutively hospitalized individuals were recruited. Fasting blood samples taken upon admission testing. Participants previously...
The natural history of the little-known Protaetia (Vietnamoprotaetia) sericophora (Seillière, 1910) (Coleoptera, Scarabaeidae, Cetoniinae) in China is documented. Records from Guangdong, Guangxi, and Yunnan have significantly extended distribution range this species. female illustrated for first time sexual dimorphism presented. Photographs habitus, parameres, type materials beetle are also provided. observations on habitat its larvae provided new insights capturing flower beetles occurring...
Pleuronota rufosquamosa (Fairmaire, 1893) is a little-known flower beetle from southern China and northern Vietnam, due to taxonomic changes, the genus Kraatz, 1892 species became new records of China. Morphological characteristics adults are redescribed. Descriptions 3rd instar larvae pupae also provided, morphological differences compared with four genera subtribe Taenioderina. All structures supplemented by photographs. The life history P. briefly summarized based on field observation...
Bladder cancer is the most common tumor of urinary tract. Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ), a gene encoding 14-3-3ζ protein, has been observed to be frequently amplified in bladder cancer. However, role various types controversial. With reproduction The Cancer Genome Atlas database, we searched correlation YWHAZ expression with survival outcomes multiple cancers silico. Our results revealed that only was there positive trend overexpression....
We investigated the effectiveness of NTrap in prevention stone retropulsion during ureteroscopic Ho:YAG laser lithotripsy upper ureteral calculi. A total 308 patients with stones treated by semirigid were stratified into two groups which 152 without use assigned to Group I and 156 II. Patient gender, age, size, operative time, parameters for migration compared between groups. The difference patient size insignificant Longer duration (P = 0.000) was observed II showed a higher intraoperative...
Abstract Background Chromosomal rearrangements are common in clear cell renal carcinoma (ccRCC) and their roles mediating sensitivity to tyrosine kinase inhibitors (TKIs) mTOR (mTORi) remain elusive. Methods We developed an silico strategy by screening copy number variance (CNV) that was potentially related TKI or mTORi ccRCC reproducing the TCGA GDSC datasets. Candidate genes should be both significantly prognostic drug resistance, were then validated vitro. Results ADCYAP1 loss GNAS gain...