A5103064866- Renal cell carcinoma treatment
- Renal and related cancers
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Adrenal and Paraganglionic Tumors
- Ginkgo biloba and Cashew Applications
- Mitochondrial Function and Pathology
- Glioma Diagnosis and Treatment
- Connexins and lens biology
- Lipid metabolism and disorders
- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Magnolia and Illicium research
- Prostate Cancer Diagnosis and Treatment
- Heat shock proteins research
- Ultrasound and Hyperthermia Applications
- Prostate Cancer Treatment and Research
Fudan University
2020-2023
Huashan Hospital
2020-2023
Kinases play critical role in clear-cell renal cell carcinoma (ccRCC). We aim to exploit novel kinase that is both protumorigenic and drugable ccRCC.
Aim The action of immune checkpoint inhibition (ICI) largely depends on antibody-dependent cellular phagocytosis (ADCP). We thus aim to develop ADCP-based ccRCC risk stratification as both prognostic and therapeutic markers ICI. Method Genomic data from multiple public datasets (TCGA, etc.) were integrated. A cancer-intrinsic ADCP gene set for tailored a recent report was constructed based the association with prognosis, infiltrates, response Therapeutic potential profiled using genome-drug...
We aim to explore association between copy number alteration (CNA) and sensitivity common tyrosine kinase inhibitors (TKIs) used in clear-cell renal cell carcinoma (ccRCC) treatment.CNA with related profiles were extracted from the Genomics of Drug Sensitivity Cancer (GDSC) dataset was cross-referenced CNA ccRCC Genome Atlas (TCGA) dataset. Functional annotation profiled using GSEA NET-GE. Target genes within cytobands interest screened silico validated vitro proliferation assays A498 786-O...
Background: To report outcomes of patients undergoing brachytherapy (BT), investigate factors associated with biochemical progression-free survival (bPFS) and to compare its long-term prognosis that radical prostatectomy (RP) in localized prostate cancer. Methods: The clinical data 87 elderly cancer who underwent BT at Huadong Hospital affiliated Fudan University from January 2009 December 2016 were retrospectively analyzed. Patient prognoses investigated using univariate multivariate Cox...
Adrenocortical carcinoma (ACC) is a rare but aggressive disease that lacks definitive treatment. We aim to evaluate role of ASXL1 in ACC and exploit its therapeutic merits therein. performed silico reproduction datasets the Cancer Genome Atlas (TCGA), GDSC (Genomics Drug Sensitivity Cancer) Human Protein using platforms cBioPortal, UALCAN, NET-GE, GSEA GEPIA. Validation was tissue, vitro vivo NCI-H295R SW-13 cells. gained over 50% cases with mRNA overexpressed DNA cases. overexpression...