A5006996149- Natural product bioactivities and synthesis
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Essential Oils and Antimicrobial Activity
- Liver Disease Diagnosis and Treatment
- Bee Products Chemical Analysis
- Renal and related cancers
- Diet, Metabolism, and Disease
- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
- Phytochemistry and Biological Activities
- Ferroptosis and cancer prognosis
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Traditional Chinese Medicine Analysis
- Toxin Mechanisms and Immunotoxins
- Gallbladder and Bile Duct Disorders
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Phytochemical and Pharmacological Studies
- Galectins and Cancer Biology
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- Traditional Chinese Medicine Studies
Guangdong Pharmaceutical University
2011-2024
Ministry of Education of the People's Republic of China
2021-2024
Fudan University
2021-2023
Huashan Hospital
2021-2023
Integrated Chinese Medicine (China)
2019-2021
Huizhou Central People's Hospital
2014-2021
Chongqing University
2019
Xiamen University
2019
Guangzhou Medical University
2012-2013
Guangzhou First People's Hospital
2012-2013
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic worldwide. The advanced stage of NAFLD, non-alcoholic steatohepatitis (NASH), been recognized as a leading cause end-stage injury for which there are no FDA-approved therapeutic options. Glutathione S-transferase Mu 2 (GSTM2) is phase II detoxification enzyme. However, roles GSTM2 in NASH have not elucidated.Multiple RNA-seq analyses were used to identify hepatic expression NASH. In vitro and vivo gain- or...
In healthy joints, synovial fibroblasts (SFs) provide the microenvironment required to mediate homeostasis, but these cells adopt a pathological function in rheumatoid arthritis (RA). Carbohydrates (glycans) on cell surfaces are fundamental regulators of interactions between stromal and immune cells, little is known about role SF glycome joint inflammation. Here we study guided pathophysiology by mapping SFs glycosylation pathways. Combining transcriptomic glycomic analysis, show that...
Scope Ample evidence supports the prominent role of gut‐liver axis in perpetuating pathological networks high‐fat high‐fructose (HFF) diet induced metabolic disorders, however, molecular mechanisms are still not fully understood. Herein, this study aims to present a holistic delineation and scientific explanation for crosstalk between gut liver, including potential mediators involved orchestrating immune systems. Methods Results An experimental obesity‐associated metaflammation rat model is...
Colorectal cancer (CRC) remains one of the most common cancers worldwide. Increasing evidence indicates that SPRY4 intronic transcript 1 (SPRY4-IT1) regulate cell growth, differentiation, apoptosis, and progression. However, expression function SPRY4-IT1 in progression CRC largely unknown. Here, we reported was upregulated CRC. Increased associated with larger tumor size higher clinical stage. In vitro experiments revealed knockdown significantly inhibited proliferation by causing G1 arrest...
Brazilian green propolis is a complex mixture of natural compounds that difficult to analyze and standardize; as result, controlling its quality challenging. In this study, we used the positive negative modes ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time flight mass spectrometry in conjunction high-performance for identification characterization seven phenolic acid propolis. The optimal operating conditions source were capillary voltage 3500 V...
A comparative study between Chinese propolis and Brazilian green showed that they have a distinct chemome but similar antioxidant anti-inflammatory potential.
Kinases play critical role in clear-cell renal cell carcinoma (ccRCC). We aim to exploit novel kinase that is both protumorigenic and drugable ccRCC.
Background The gut microbiome affects the occurrence and development of NAFLD, but its mechanism has not yet been fully elucidated. Chinese medicine is a new treatment strategy to improve NAFLD by regulating microbiome. Tianhuang formula (TH) proved have lipid-lowering effect in which constituents ginsenoside Rb1, Rg1, Rb, Re, R1 from Panax notoginseng berberine, palmatine, coptisine Coptis chinensis low drug permeability, results poor intestinal absorption into human body, are thus able...
Ubiquitin-specific protease (USP) 6 is a hominoid deubiquitinating enzyme previously implicated in intellectual disability and autism spectrum disorder. Although these findings link USP6 to higher brain function, potential roles for cognition have not been investigated. Here, we report that highly expressed induced human neurons neuron-specific expression of enhances learning memory transgenic mouse model. Similarly, regulates N-methyl-D-aspartate-type glutamate receptor (NMDAR)-dependent...
Aim The action of immune checkpoint inhibition (ICI) largely depends on antibody-dependent cellular phagocytosis (ADCP). We thus aim to develop ADCP-based ccRCC risk stratification as both prognostic and therapeutic markers ICI. Method Genomic data from multiple public datasets (TCGA, etc.) were integrated. A cancer-intrinsic ADCP gene set for tailored a recent report was constructed based the association with prognosis, infiltrates, response Therapeutic potential profiled using genome-drug...
Thousands of years ago, humans started to use propolis because its medicinal properties, and modern science has successfully identified several bioactive molecules within this resinous bee product. However, a natural extract which been removed the adhesive glue preserved compounds is urgently needed maximise therapeutic opportunities. In study, novel ultrafiltrate fraction from Brazilian green propolis, termed P30K, was demonstrated with anti-inflammatory both in vitro vivo. Total flavonoids...
Dyslipidemia and hepatic steatosis are the characteristics of initial stage nonalcohol fatty liver disease (NAFLD), which can be reversed by lifestyle intervention, including dietary supplementation. However, such commercial supplements with solid scientific evidence in particular clear mechanistic elucidation scarce. Here, health benefits MHP, a mulberry
Amplitudes of seiches are generally very small in Chinese coastal waters with the exception Longkou Harbour, where some extraordinary have occurred. Tide gauge records over a period twenty-three years, including 137 maximum fluctuation greater than 40 cm, were examined. Preliminary results given here include variabilities occurrences, distributions mean periods, fluctuations, and occurrence durations, along list large seiches. In addition, an illustration seiche on 1 September 1980 293 cm is given.
Colorectal cancer (CRC) is one of the most common types worldwide. Recently, microRNAs (miRs) have been considered as novel therapeutic targets for treatment cancer. miR‑598 a poorly investigated miR. The underlying mechanism in CRC cells remains to be elucidated. In present study, was demonstrated significantly upregulated tissue by analyzing data from Cancer Genome Atlas and Gene Expression Omnibus. results polymerase chain reaction that expression tissues cells. Gain function loss assays...
Pectolinarin and linarin are two major flavone O-glycosides of Cirsium japonicum, which has been used for thousands years in traditional Chinese medicine. Pharmacological research on pectolinarin is meaningful necessary. Here, a process the purification from C. japonicum was established using macroporous resin enrichment followed by prep-HPLC separation. The results show purity reached 97.39% 96.65%, respectively. vitro bioactivities result shows ORAC values 4543 1441 µmol TE/g,...
Abstract A major goal of healthy aging is to prevent declining resilience and increasing frailty, which are associated with many chronic diseases deterioration stress response. Here, we propose a loss‐or‐gain survival model, represented by the ratio cumulative span life span, quantify at organismal level. As proof concept, this demonstrated reduced in Caenorhabditis elegans exposed exogenous oxidative induced paraquat or endogenous proteotoxic caused polyglutamine amyloid‐β aggregation....
High recurrence of colon cancer liver metastasis is observed in patients after hepatic surgery, and the cause believed to be mostly due growth residual microscopic metastatic lesions within liver. Therefore, triggering progression occult foci may a novel strategy for improving survival from metastases. In present study, we identified an anti-recurrence effect ulinastatin on mice hepatectomy. Transwell cell invasion assays demonstrated that significantly inhibited vitro invasive ability...
Obesity, a multifactorial disease with many complications, has become global epidemic. Weight management, including dietary supplementation, been confirmed to provide relevant health benefits. However, experimental evidence and mechanistic elucidation of supplements in this regard are limited. Here, the weight loss efficacy MHP, commercial solid beverage consisting mulberry leaf aqueous extract Hippophae protein peptides, was evaluated high-fat high-fructose (HFF) diet-induced rat model...
Fufang Zhenzhu Tiaozhi (FTZ) capsules have been prescribed for treating glucose and lipid metabolism disorders such as type 2 diabetes mellitus (T2DM). However, the underlying mechanism remains unknown. In this study, network pharmacology experimental verification were combined to investigate mechanisms of FTZ in T2DM. A total 176 active ingredients 1169 corresponding targets screened using biological databases. 598 potential T2DM retrieved from GeneCards, PharmGKB, OMIM, Drugbank, TTD. The...
Hyperlipidemia is a common disease caused by abnormal plasma lipid metabolism. Lipidomics powerful and efficient technology to study the integration of syndrome Chinese medicine. This investigated specific changes in metabolites from hyperlipidemia patients with liver qi‐stagnation spleen‐deficiency (SLQSD). Lipid profiles samples 29 including 10 SLQSD 19 non‐SLQSD 26 healthy volunteers (NC) were tested UPLC‐QTOF/MS. PLS‐DA analysis database searching performed discover differentiating...