A5019566020- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Mitochondrial Function and Pathology
- Sirtuins and Resveratrol in Medicine
- Autophagy in Disease and Therapy
- Diet and metabolism studies
- Muscle metabolism and nutrition
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Coenzyme Q10 studies and effects
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Physical Activity and Education Research
- Air Quality and Health Impacts
- Cancer, Hypoxia, and Metabolism
- Nutritional Studies and Diet
- Climate Change and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Sports Performance and Training
- Neurogenetic and Muscular Disorders Research
- Chromatography in Natural Products
- Genomics, phytochemicals, and oxidative stress
- Toxin Mechanisms and Immunotoxins
- Liver Disease Diagnosis and Treatment
- GDF15 and Related Biomarkers
Inha University
2017-2024
University of Minnesota
2012-2017
Cheongju University
2016
Twin Cities Orthopedics
2015
Hankuk University of Foreign Studies
2015
International College of Applied Kinesiology-USA
2014
University of Wisconsin–Madison
2007-2013
Tianjin University of Sport
2009
Abstract High-fat diet-induced obesity is a pandemic caused by an inactive lifestyle and increased consumption of Western diets major risk factor for diabetes cardiovascular diseases. In contrast, exercise can positively influence gut microbial diversity linked to decreased inflammatory state. To understand the variations associated with high-fat diet over time, we conducted longitudinal study examine effect covariates on composition. Young mice were divided into four groups: Chow-diet...
Prolonged immobilization (IM) causes skeletal muscle atrophy characterized by mitochondrial deterioration and proteolysis. Muscle remobilization (RM) increases reactive oxygen species generation, proinflammatory cytokine expression, oxidative stress, preventing from quick recovery. Thus, we hypothesized that overexpression of peroxisome proliferator-activated receptor γ coactivator 1-α (PGG1α) via in vivo transfection would promote biogenesis antioxidant defense, thus ameliorating the...
Prolonged immobilization (IM) results in skeletal muscle atrophy accompanied by increased reactive oxygen species (ROS) generation, inflammation, and protein degradation. However, the biological consequence of remobilizing such has been studied only sparsely. In this study, we examined peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α)-controlled mitochondrial biogenesis pathway inflammatory response mice subjected to 2 wk hindlimb IM followed 5 days remobilization (RM). We...
During aging, chronic systemic inflammation increases in prevalence and antioxidant balance shifts favor of oxidant generation. Avenanthramide (AVA) is a group oat phenolics that have shown anti-inflammatory capability. The present study investigated whether dietary supplementation avenanthramides oats would increase protection reduce after bout downhill walking (DW) postmenopausal women. Women at age 50–80 years (N = 16) were randomly divided into two groups double-blinded fashion,...
Hormesis plays a critical role in producing some major benefits derived from physical exercise. However whether these known cellular mechanisms are applicable to ameliorate age-related deterioration of muscle function is not entirely clear. The present communication proposes that antioxidant adaptation, the peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α activated mitochondrial biogenesis, and eccentric contraction-induced, cytokine-propelled inflammation could be...
Short-term administration of estradiol (E2) improves insulin-stimulated glucose disposal rate in early postmenopausal (EPM) women compared with a reduction late (LPM) women. The underlying mechanisms by which E2 action on reversed from beneficial to harmful menopause is unknown, but might include adverse changes estrogen receptors (ERs) or other biomarkers cellular energy metabolism age duration deficiency.We retrospectively analyzed skeletal muscle samples 27 who were 6 years less past...
Regular exercise provides several health benefits that can improve the cardiovascular and musculoskeletal systems, but clear evidence on effect of exercise-induced hyperventilation in particulate matter (PM) exposure is still lacking. This study aimed to investigate effects PM reactive oxygen species (ROS) generation, inflammatory response, mitochondrial integrity human lung epithelial cells (A549), as well mouse tissue. In vitro experiments, treatment was shown significantly increased ROS...
Obesity is a common metabolic disorder caused by sedentary lifestyle, and high-fat high-glucose diet in the form of fast foods. High-fat diet-induced obesity major cause diabetes cardiovascular diseases, whereas exercise physical activity can ameliorate these disorders. Moreover, gut microbiota are known to be interconnected, since increase microbial diversity contribute beneficial health effects. In this context, we analyzed effect on mice, next-generation sequencing bacterial V4 region 16S...
New Findings What is the central question of this study? The peroxisome proliferator‐activated receptor γ coactivator‐1α (PGC‐1α) signalling pathway plays an important role in mitochondrial biogenesis and has been shown to be activated both by acute bout exercise long‐term training. However, upstream signals control mechanisms causing adaptation its interaction with other pathways during are not clear. main finding importance? Our was that PGC‐1α‐controlled training attenuated pyrolidine...
Abstract This article focuses on the current underlying of molecular mechanisms peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) mediated pathway and discuss possible therapeutic benefits increased mitochondrial biogenesis in compensating for dysfunction ameliorating aging aging-related diseases. PGC-1α is master transcription regulator that stimulates biogenesis, by upregulating nuclear respiratory factors factor A, leading to DNA replication gene transcription. also...
Chronic inflammation is an important etiologic mechanism for muscle atrophy. Oat-derived phytochemical avenanthramides (AVAs) have been shown to suppress inflammatory responses in human clinical studies and several cell lines vitro, but their role skeletal unclear. The aim of this study was investigate whether AVA treatment can prevent tumor necrosis factor (TNF)-α-induced fiber atrophy C2C12 cells.We treated 70% confluent cells 24 h with AVA. Then, TNF-α added cell-cultured medium....
Avenanthramides (AVA) are a group of diphenolic acids found only in oats that have anti-inflammatory and antioxidant effects. Absorption AVAs humans after oral consumption natural oat flour is unknown.To examine the appearance plasma ingestion cookies estimate key pharmacokinetic parameters.Male female nonobese participants (n = 16) consumed three made with containing high (229.6 mg/kg, H-AVA) or low (32.7 L-AVA) amounts AVAs, including AVA-A, AVA-B, AVA-C. Blood samples were collected at 0,...