A5100782674- Breast Implant and Reconstruction
- Autophagy in Disease and Therapy
- Oral microbiology and periodontitis research
- Machine Learning in Healthcare
- Reconstructive Surgery and Microvascular Techniques
- Breast Cancer Treatment Studies
- Neuroendocrine Tumor Research Advances
- Research in Cotton Cultivation
- Peptidase Inhibition and Analysis
- Photosynthetic Processes and Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Cellular transport and secretion
- Omental and Epiploic Conditions
- Immune Response and Inflammation
- COVID-19 Clinical Research Studies
- Plant Molecular Biology Research
- Biofuel production and bioconversion
- Endodontics and Root Canal Treatments
- COVID-19 diagnosis using AI
- Plant-Microbe Interactions and Immunity
- Viral Infections and Immunology Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Systemic Lupus Erythematosus Research
- Artificial Intelligence in Healthcare and Education
- Cell death mechanisms and regulation
Sichuan University
2021-2025
Yale University
2021-2025
Huazhong University of Science and Technology
2017-2025
Southern Medical University
2022-2024
Nanfang Hospital
2022-2024
Fudan University Shanghai Cancer Center
2024
Heilongjiang Bayi Agricultural University
2024
University of Glasgow
2024
State Key Laboratory of Oral Diseases
2022-2023
University of California, San Francisco
2022-2023
Abstract Objective This study investigated the influence of Coronavirus Disease 2019 (COVID-19) on lung function in early convalescence phase. Methods A retrospective COVID-19 patients at Fifth Affiliated Hospital Sun Yat-sen University were conducted, with serial assessments including volumes (TLC), spirometry (FVC, FEV1), diffusing capacity for carbon monoxide (DLCO),respiratory muscle strength, 6-min walking distance (6MWD) and high resolution CT being collected 30 days after discharged....
Excessive nuclear factor-κB (NF-κB) activation mediated by tumor necrosis factor α (TNFα) plays a critical role in inflammation. Here we demonstrate that angiopoietin-like 8 (ANGPTL8) functions as negative feedback regulator TNFα-triggered NF-κB intracellularly. Inflammatory stimuli induce ANGPTL8 expression, and knockdown or knockout of potentiates TNFα-induced vitro. Mechanistically, upon TNFα stimulation, facilitates the interaction IKKγ with p62 via forming complex, thus promoting...
To create and validate a simple transferable machine learning model from electronic health record data to accurately predict clinical deterioration in patients with covid-19 across institutions, through use of novel paradigm for development code sharing.Retrospective cohort study.One US hospital during 2015-21 was used training internal validation. External validation conducted on admitted at 12 other medical centers 2020-21.33 119 adults (≥18 years) respiratory distress or covid-19.An...
Omental adipose stromal cells (O-ASC) are a multipotent population of mesenchymal stem contained in the omentum tissue that promote endometrial and ovarian tumor proliferation, migration, drug resistance. The mechanistic underpinnings O-ASCs' role progression growth unclear. Here, we propose novel nitric oxide (NO)-mediated metabolic coupling between O-ASCs gynecologic cancer which support NO homeostasis malignant cells. is synthesized endogenously by conversion l-arginine into citrulline...
Objective This study is performed to investigate the imaging characteristics of International Association for Study Lung Cancer grade 3 invasive adenocarcinoma (IAC) on PET/CT and value preoperative predicting this tumor. Materials methods We retrospectively enrolled patients with IAC from August 2015 September 2022. The clinical characteristics, serum tumor markers, features were analyzed. T test, Mann–Whitney U χ 2 Logistic regression analysis, receiver operating characteristic analysis...
The NAC family of transcription factors includes no apical meristem (NAM),
ABSTRACT Coxiella burnetii is a highly virulent intracellular pathogen that causes acute and chronic Q fever in humans. The bacterium utilizes Dot/Icm type IV secretion system (T4SS) to translocate over 100 effectors into host cells facilitate biogenesis of -containing vacuoles (CCVs), which are specialized lysosome-derived organelles support bacterial replication. During replication CCVs, C. undergoes unique biphasic developmental cycle defined by two distinct cellular forms: the infectious...
Abstract Circadian rhythm disorders and NF-κB are closely linked can exacerbate periodontitis. However, the mechanisms via which circadian rhythm-related genes influence periodontitis not yet fully understood. Objective We investigated effect of brain muscle Arnt-like protein-1 (BMAL1) on pathway downstream inflammatory factors In this study, Bmal1 homozygous knockout mouse models were established. Methodology Bone marrow-derived macrophages (BMDMs) from Bmal1-/- mice cultured stimulated...
For patients with small breasts, breast-conserving surgery (BCS) and unilateral nipple-/skin-sparing mastectomy (N/SSM) breast reconstruction may result in visible deformities or asymmetry, contralateral augmentation often require a two-staged operation. We propose novel endoscopic technique, direct-to-implant simultaneous (DTI-BR-SCBA), report its short-term safety cosmetic outcomes.In this prospective study, early cancer who underwent DTI-BR-SCBA between November 2020 August 2022 were...
Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB) are neurodegenerative disorders characterized by the accumulation of α-synuclein aggregates. forms droplets via liquid-liquid phase separation (LLPS), followed liquid-solid (LSPS) to form amyloids, how this process is physiologically-regulated remains unclear. β-synuclein colocalizes in presynaptic terminals. Here, we report that partitions into condensates promotes LLPS, slows down LSPS α-synuclein, while disease-associated...
Abstract Objective To explore the mechanism of receptor‐interacting protein 1 (RIP1)‐mediated necroptosis during periodontitis progression. Background RIP3 and mixed lineage kinase domain‐like (MLKL) have been detected to be upregulated in models. Because RIP1 is involved necroptosis, it might also play a role progression periodontitis. Methods An experimental model BALB/c mice was established by inducing oral bacterial infection. Western blotting immunofluorescence analyses were used detect...
There is a need for systematic method to implement the World Health Organization's Clinical Progression Scale (WHO-CPS), an ordinal clinical severity score coronavirus disease 2019 patients, electronic health record (EHR) data. We discuss our process of developing guiding principles mapping EHR data WHO-CPS scores across multiple institutions.
Exploiting effective therapies to fight tumor growth is an important part of modern cancer research. The anti-cancer activities many plant-derived substances are well known, in because the often extensively distributed. Chicoric acid, a phenolic compound widely distributed plants, has drawn widespread attention recent years its extraordinary activities. However, traditional methods for quantifying chicoric acid inefficient and time-consuming. In this study, ultrasensitive non-enzymatic...
Inflammation plays a major role in the pathogenesis of several vascular pathologies, including abdominal aortic aneurysm (AAA). Evaluating inflammation AAA pathobiology and potentially outcome
Abstract Exposure of dark-grown etiolated seedlings to light triggers the transition from skotomorphogenesis/etiolation photomorphogenesis/de-etiolation. In life cycle plants, de-etiolation is essential for seedling development and plant survival. The mobilization soluble sugars (glucose [Glc], sucrose, fructose) derived stored carbohydrates lipids target organs, including cotyledons, hypocotyls, radicles, underpins de-etiolation. Therefore, dynamic carbohydrate biochemistry a key feature...