A5052956856- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Power Systems and Renewable Energy
- CAR-T cell therapy research
- Exercise and Physiological Responses
- Shoulder and Clavicle Injuries
- Bone Tissue Engineering Materials
- Nerve Injury and Rehabilitation
- Single-cell and spatial transcriptomics
- Sarcoma Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
Shanghai University of Electric Power
2024
Southwest Hospital
2021-2022
Army Medical University
2021-2022
Osteolysis at the tendon-bone interface can impair pullout strength during healing and lead to surgery failure, but effects of clinical treatments are not satisfactory. Mesenchymal stem cell (MSC)-derived exosomes have been used as potent feasible natural nanocarriers for drug delivery proven enhance strength, indicating that MSC-derived could be a promising therapeutic strategy. In this study, we explored Scleraxis (Scx) dynamically expressed in PDGFRα(+) bone marrow-derived mesenchymal...
Osteosarcoma is the most common malignant bone tumor in adolescents, and metastasis key reason for treatment failure poor prognosis. Once occurs, 5-year survival rate only approximately 20%, assessing predicting risk of osteosarcoma are still difficult tasks. In this study, cellular communication between cells nontumor was identified through comprehensive analysis single-cell RNA sequencing (scRNA-seq) bulk RNA-seq data, illustrating complex regulatory network microenvironment. line with...
Studies have shown that the stem cell microenvironment is a key factor for maintenance or differentiation. In this study, we compared expression of 23 cytokines such as IL-6, IL-10, and TNFα between young aged rats during patellar tendon repair by cytokine microarray, found significant difference G-CSF, VEGF at 3, 7, 14 days post-operatively. The effects these factors on adipogenic differentiation TPSCs were examined through western blot oil red O experiments. It was had an inhibitive effect...
The reconstruction of a tendon insertion on metal prostheses is challenge in orthopedics. Of the available prostheses, porous have been shown to better biocompatibility for tissue integration. Therefore, this study aimed at identifying an appropriate structure prostheses.Ti6Al4V specimens with diamond-like triply periodic minimal surface pore sizes 300, 500, and 700 μm porosity 58% (designated Ti300, Ti500, Ti700, respectively) were manufactured by selective laser melting characterized...
Tendon stem/progenitor cells (TSPCs) play a vital role in tendon repair and regeneration. Previously we found more adipocytes accumulated the patellar injury sites aging rats compared with young ones, of which mechanism is still unknown. Here, want to identify whether erroneous differentiation TSPCs by accounts for adipocyte accumulation.TSPCs from were isolated propagated. Both induced differentiate into adipocytes, Oil red O staining, quantitative real-time polymerase chain reaction...