A5008892054- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Cervical and Thoracic Myelopathy
- Inflammasome and immune disorders
- Gout, Hyperuricemia, Uric Acid
- Orthopaedic implants and arthroplasty
- Peptidase Inhibition and Analysis
- Spinal Hematomas and Complications
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related gene regulation
- Hippo pathway signaling and YAP/TAZ
- Medical Imaging and Analysis
Hangzhou First People's Hospital
2020-2024
Zhejiang University
2020-2023
Osteoarthritis (OA), in which macrophage-driven synovitis is considered closely related to cartilage destruction and could occur at any stage, an inflammatory arthritis. However, there are no effective targets cure the progression of OA. The NOD-, LRR-,and pyrin domain-containing protein 3 (NLRP3) inflammasome synovial macrophages participates pathological process treatment strategies targeting it be approach for PIM-1 kinase, as a downstream effector many cytokine signaling pathways, plays...
Abstract Background Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and endoscopic (Endo-LIF) are both minimally procedures for degenerative diseases. In this study, we attempted to compare the clinical efficacy postoperative outcomes of MIS-TLIF Endo-LIF Methods The study cohort comprised 99 patients with diseases treated by or from January 2019 July 2021. (visual analogue scale (VAS), Oswestry disability index (ODI), MacNab criteria) preoperatively, 1 month...
The study of chondrogenic progenitor cells (CPCs) as seed has become a new focus cartilage regeneration. inflammatory environment osteoarthritis (OA) inhibits the repair ability CPCs. But OA patients’ CPCs showed an excellent regeneration with intermittent hydrostatic pressure (IHP). However, mechanism is unclear. We compared expression Hippo signaling effect factor YAP between and normal cartilages. Then, relationship Kellgren-Lawrence (K-L) score rate YAP-positive was analyzed. changes...
Abstract Purpose: Thoracolumbar disc herniation, a rare disorder, has unique characteristics that can result in undesirable surgical outcomes after traditional discectomy. In view of the widespread use percutaneous endoscopic transforaminal discectomy for lower lumbar we investigated treatment thoracolumbar herniation by this procedure. The purpose study was to evaluate clinical efficacy and treating herniation. Methods: We retrospectively evaluated data 19 patients who had undergone our...
Abstract Background: Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and endoscopic (Endo-LIF) are both new minimally procedures for degenerative diseases. In this study, we attempted to compare the clinical efficacy postoperative outcomes of MIS-TLIF Endo-LIF Methods: The study cohort comprised 99 patients with diseases treated by or from January 2019 July 2021. (visual analogue scale (VAS), Oswestry disability index (ODI), MacNab criteria) preoperatively, 1 month...
Abstract Background Osteoarthritis (OA), in which macrophage-driven synovitis is considered closely related to cartilage destruction and could occur at any stage, an inflammatory arthritis. However, there are no effective targets cure the progression of OA. The NLRP3 inflammasome synovial macrophages participates pathological process treatment strategies targeting it be approach for PIM-1 kinase, as a downstream effector many cytokine signaling pathways, plays pro-inflammatory role disease....
Abstract The authors have requested that this preprint be removed from Research Square.