A5100405843- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Head and Neck Anomalies
- BRCA gene mutations in cancer
- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- RNA modifications and cancer
- Thyroid Disorders and Treatments
- Biomarkers in Disease Mechanisms
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- RNA Research and Splicing
- Vitamin D Research Studies
- Meningioma and schwannoma management
- Cancer-related gene regulation
- Pituitary Gland Disorders and Treatments
- Circular RNAs in diseases
- Neuroendocrine Tumor Research Advances
- S100 Proteins and Annexins
- Viral-associated cancers and disorders
- Myasthenia Gravis and Thymoma
- Intracerebral and Subarachnoid Hemorrhage Research
- Brain Metastases and Treatment
- Glutathione Transferases and Polymorphisms
- Cancer Risks and Factors
Hainan Medical University
2025
China Medical University
2014-2024
First Hospital of China Medical University
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
State Key Laboratory of Oral Diseases
2021
Sichuan University
2021
Wenzhou Medical University
2006
First Affiliated Hospital of Wenzhou Medical University
2006
N6-methyladenosine (m6A) modification is the most common chemical in mammalian mRNAs, and it plays important roles by regulating several cellular processes. Previous studies report that m6A implicated modulating tumorigenesis progression. However, dysregulation of effect demethylase fat-mass obesity-associated protein (FTO) on glucose metabolism has not been fully elucidated papillary thyroid cancer (PTC).Quantitative real-time PCR (qRT-PCR), western blotting immunohistochemistry were...
Abstract Nuclear paraspeckle assembly transcript 1 (NEAT1), a long non-coding RNA (lncRNA), is core structural component of paraspeckles and essential for formation. NEAT1 comprises two different isoforms: NEAT1_1 (3.7 kb) NEAT1_2 (23 kb). Recently, has been shown to have oncogenic roles facilitate tumorigenesis in various human cancers. However, the function papillary thyroid cancer (PTC) not well understood. The relative expression levels NEAT1_2, ATPase family AAA domain-containing...
Background: An increase in the prevalence of thyroid disease has been found with increasing iodine intake, since universal salt iodization (USI) was instituted throughout China 1996. The aim this study to analyze incidence carcinoma (TC) before and after USI Shenyang, a city northeastern China. Material/Methods: pathology reports were collected from patients diseases who underwent surgery First Hospital Medical University January 1, 1992 December 31, 2009. detection rate, constituent ratio,...
Abstract Epigenetic dysregulation plays an important role in cancer. Histone demethylation is a well‐known mechanism of epigenetic regulation that promotes or inhibits tumourigenesis various malignant tumours. However, the pathogenic histone modifiers papillary thyroid cancer (PTC), which has high incidence early lymphatic metastasis, largely unknown. Here, we detected expression common and found H3 lysine 4 (H3K4) 9 (H3K9) demethylase KDM1A (or 1A) frequently overexpressed PTC tissues cell...
MicroRNA-663 (miR-663) has been detected in a large variety of tumor types; however, it still holds both suppressive and oncogenic roles different types. The miRNA-CHIP microarray assay revealed downregulation miR-663 papillary thyroid carcinoma (PTC); the effect on PTC cell invasion migration remains unknown. Accordingly, this study aimed to investigate potential involvement PTC. In study, expression level was measured via quantitative real-time PCR 91 pairs human adjacent normal tissues...
Identifying risk variables for cervical lymph node metastases in multifocality papillary thyroid cancer (MPTC) could assist surgeons determining whether dissection would be an appropriate surgical option.A retrospective cohort of 2006 patients with were selected. MPTC (N = 460) was defined as the presence two or more foci PTC. The factors central metastasis (CLNM) and lateral (LLNM) investigated by univariate multivariate analyses, including following items: age at diagnosis, gender,...
Children with papillary thyroid cancer (PTC) have a higher invasive rate and distant metastasis rate, but the mortality is lower unknown reasons. The majority of PTC cases comprise classical carcinoma (CPTC) follicular variant (FVPTC). This study aimed to determine relationship between histopathological subtype investigate factors influencing in pediatric PTC. A total 102,981 patients were recruited from SEER registry, 2004-2015. Proportion children (≤18 years) adults different subtypes was...
Papillary thyroid carcinoma (PTC), the most common histological subtype of cancer, accounts for between 80 and 90% all cancer cases. Previous studies have suggested that microRNAs (miRNAs/miRs) are involved in development PTC. The aim present study was to investigate whether miR-144 inhibits cellular proliferation expression detected PTC corresponding adjacent non-cancerous tissues, cell line IHH4, using reverse transcription-quantitative polymerase chain reaction. Associations levels...
BACKGROUND:Low levels of 1-25-dihydroxyvitamin D3 [1,25(OH)2D3] in serum may be a risk factor for several tumor types. Also, high cathelicidin antimicrobial peptide (CAMP) expression is regarded to important against progression. We evaluated the potential importance 1,25(OH)2D3 diagnosis and treatment papillary thyroid cancer (PTC). MATERIAL AND METHODS:The preoperative level was measured using double-antibody sandwich enzyme-linked immunosorbent assay. Vitamin receptor (VDR) detected by...
Abstract There is increasing evidence that vitamin D deficiency the risk factor for multiple diseases, such as immune disorder, cardiovascular disease and cancer. Calcitriol active form of with beneficial effects on anti‐cancer by binding receptor (VDR). The primary aim this study was to investigate role papillary thyroid carcinoma (PTC) explore possible mechanism. We found nuclear VDR expression in PTC samples negatively correlated STAT3 hyperphosphorylation indicated worse...
Summary Oestrogens play an important role in the development and progression of papillary thyroid carcinoma (PTC) through oestrogen receptor (ER)‐α ‐β, which may exert different or even opposing actions PTC. The roles ERβ ERα‐negative PTC are still not clear. This study investigated expression dynamics ERβ1 (wild‐type ERβ) its clinical significance female patients. was detected tissues 136 patients diagnosed with relationships between clinicopathological/biological factors were also analysed...