A5065480015- Microbial infections and disease research
- Herpesvirus Infections and Treatments
- Mycobacterium research and diagnosis
- Retinoids in leukemia and cellular processes
- Vector-Borne Animal Diseases
- Viral Infections and Vectors
- Aquaculture disease management and microbiota
- Genetic and phenotypic traits in livestock
- Antioxidant Activity and Oxidative Stress
- Veterinary Oncology Research
- Medical Imaging and Pathology Studies
- Bacteriophages and microbial interactions
- Vector-borne infectious diseases
- Animal Disease Management and Epidemiology
- Prion Diseases and Protein Misfolding
- Estrogen and related hormone effects
- Animal Genetics and Reproduction
- Veterinary Orthopedics and Neurology
- Developmental Biology and Gene Regulation
- Retinal Development and Disorders
- Pneumonia and Respiratory Infections
- Indigenous Studies and Ecology
- Viral gastroenteritis research and epidemiology
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
University of Wisconsin–Madison
1998-2025
Kansas State University
2020-2024
University of California, Davis
2009-2022
United States Department of Agriculture
2012-2022
Agricultural Research Service
2012-2022
University of Florida
2022
Animal Welfare Institute
2022
New England Aquarium
2022
NOAA National Marine Fisheries Service
2022
Washington State University
2012-2021
Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form wool represent distinct class animals that have specialized digestive organ, rumen, carries out initial digestion plant material. We developed analyzed high-quality reference sheep genome transcriptomes from 40 different tissues. identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. also involved lipid metabolism had been amplified and/or altered tissue expression...
Vitamin A is required for reproduction and normal embryonic development. We have determined that all- trans- retinoic acid (atRA) can support development of the mammalian embryo to parturition in vitamin A-deficient (VAD) rats. At day (E) 0.5, VAD dams were fed purified diets containing either 12 μg atRA per g diet (230 rat day) or 250 (4.5 mg supplemented with a source retinol (100 units retinyl palmitate day). An additional group was both combination palmitate. Embryonic survival E12.5...
Epizootic pneumonia of bighorn sheep is a devastating disease uncertain etiology. To help clarify the etiology, we used culture and culture-independent methods to compare prevalence bacterial respiratory pathogens Mannheimia haemolytica, Bibersteinia trehalosi, Pasteurella multocida, Mycoplasma ovipneumoniae in lung tissue from 44 herds affected by 8 outbreaks western United States. M. ovipneumoniae, only agent detected at significantly higher animals (95%) than unaffected healthy...
Book reviews express the opinions of individual authors regarding value book's content for Journal Wildlife Diseases readers. The are subjective assessments and do not necessarily reflect editors, nor they establish an official policy Disease Association.
Tick-borne Anaplasma species are obligate, intracellular, bacterial pathogens that cause important diseases globally in people, agricultural animals, and dogs. Targeted mutagenesis methods yet to be developed define genes essential for these pathogens. In addition, vaccines conferring protection against caused by not available. Here, we describe a targeted method deletion of the phage head-to-tail connector protein ( phtcp ) gene marginale . The mutant did disease exhibited attenuated growth...
Background Despite the theoretical advantages of treating metastatic bone disease with microwave ablation (MWA), there are few reports characterizing absorption and bioheat transfer in bone. This report describes a computational modeling-based approach to simulate directional (dMWA) spine, supported by ex vivo pilot experiments porcine vertebral bodies.
A6-year-old male castrated Greyhound was presented to the William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, with a 4-week history apparent spinal pain and paraparesis. There no improvement despite treatment consisting oral carprofen (unknown dose) for 10 days followed by tapering course prednisone 6 before referral (1.2–0.2 mg/kg/d). Abnormalities on physical examination included 5% dehydration, large flaccid bladder that easily expressed, moderate...
Human-adipose-derived mesenchymal stem cells (hADMSCs) are adult and relatively easy to access compared other sources of (MSCs). They have shown immunomodulation properties as well effects in improving tissue regeneration. To better stimulate preserve the therapeutic hADMSCs, biomaterials for cell delivery been studied extensively. date, hyaluronic acid (HA)-based materials most widely adopted by researchers around world. PGmatrix is a new peptide-based hydrogel that has superior functional...
Lamb health is crucial for producers; however, the percentage of lambs that die before weaning still 15-20%. One factor can contribute to lamb deaths congenital diseases. A novel semi-lethal disease has been identified in newborn Polypay and termed dozer syndrome. This study aims determine if there a genetic predisposition These are weak unable lift their heads, suckle, swallow, resulting nasal reflux. Genetic analyses, including genome-wide association, runs homozygosity, fine mapping...
Abstract Purpose Effective therapies for solid tumors, including breast cancers, are hindered by several roadblocks that can be largely attributed to the fibrotic extracellular matrix (ECM). Fibronectin (FN) is a highly upregulated ECM component in tumor stroma and associated with poor patient prognosis. This study aimed investigate therapeutic potential of an anti-fibrotic peptide specifically targets FN blocks fibrillar assembly FN. Methods To target FN, we used PEGylated Functional...
Three kittens, ages 5, 9, and 17 weeks, were found dead by separate caregivers submitted for necropsy. At gross necropsy, each kitten had hemorrhagic or bloody fibrinoserous thoracic fluid differing distributions of pulmonary consolidation. On histologic examination, the lesion in was similar characterized acute necrotizing pneumonia pleuritis, with numerous intralesional small Gram-negative rods. A pure culture a distinct serotype Escherichia coli identified lung tissue from (O4:H5, O6:H7,...
Small ruminant lentivirus (SRLV), also called ovine progressive pneumonia virus or maedi-visna, is present in 24% of US sheep. Like human immunodeficiency virus, SRLV a macrophage-tropic that causes lifelong infection. The production impacts from are due to range disease symptoms, including pneumonia, arthritis, mastitis, body condition wasting and encephalitis. There no cure effective vaccine for preventing However, breed differences prevalence proviral concentration indicate genetic basis...
Background Normal embryonic development and survival in utero is dependent on an adequate supply of vitamin A. Embryos from A-deficient (VAD) pregnant rats fed inadequate amount all-trans retinoic acid (atRA; 12 μg per g diet or ∼230 rat day) exhibit severe developmental abnormalities the anterior cardinal vein hindbrain by day (E) 12.5 die shortly thereafter. Methods In present study, we sought to determine whether supplementation VAD-RA supported (12 diet) with retinol (ROL) at...
Domestic and wild sheep are the natural reservoirs for ovine gammaherpesvirus 2 (OvHV-2), causative agent of sheep-associated malignant catarrhal fever (SA-MCF). Virtually all adult infected with OvHV-2 under flock conditions, infection is normally subclinical. MCF-like clinical signs typical histologic lesions in have been linked during case investigations at veterinary diagnostic laboratories; however, confirmation naturally occurring MCF problematic. To date, assays detection...
Coxiella burnetii is a globally distributed zoonotic bacterial pathogen that causes abortions in ruminant livestock. In humans, an influenza-like illness results with the potential for hospitalization, chronic infection, abortion, and fatal endocarditis. Ruminant livestock, particularly small ruminants, are hypothesized to be primary transmission source humans. A recent Netherlands outbreak from 2007-2010 traced dairy goats resulted over 4,100 human cases estimated costs of more than 300...
Mycoplasma ovipneumoniae has been reported in association with respiratory disease the wild only members of subfamily Caprinae family Bovidae. We identified M. a cervid: free-ranging barren ground caribou (Rangifer tarandus granti) yearling polymicrobial bronchopneumonia.
Mycoplasma ovis is a hemotropic bacterium reported to infect sheep, goats, and deer species. Infection in these species can result anemia, jaundice, ill-thrift. Although of worldwide distribution, only rare reports this the United States exist. The objectives retrospective study were identify prevalence distribution M. ovis, associated demographic management risk factors, reproductive production outcomes with infection on domestic sheep (Ovis aries) operations States. As part Department...
A novel respiratory-associated Mycoplasma species (M. sp. nov.) of unknown clinical significance was recently identified that causes false positive results with multiple published PCR methods reported to specifically detect ovipneumonaie, a well-known respiratory pathogen in small ruminants. This necessitates our objective develop real-time (qPCR) assay for improved specificity and sensitivity, more rapid detection differentiation M. ovipneumoniae the nov. domestic sheep (DS) goat (DG)...
A 33-year-old brown bear ( Ursus arctos) was evaluated for chronic cough, partial anorexia, and lethargy in early fall of 2009. Radiographs revealed a generalized increase interstitial density with focal lung field consolidation air bronchograms more prevalent the cranial lobes. Tracheal sputum wash fluid grew mixed bacteria 2 species Candida on bacterial fungal cultures, respectively. Serum negative antibodies to Aspergillus, Blastomyces, Coccidioides, Histoplasma by semiquantitative radial...