A5061233947- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- Genomics and Chromatin Dynamics
- Genetic and phenotypic traits in livestock
- Estrogen and related hormone effects
- Helminth infection and control
- Epigenetics and DNA Methylation
- Vector-borne infectious diseases
- Molecular Biology Techniques and Applications
- Microbial infections and disease research
- Insect and Pesticide Research
- Genetic Mapping and Diversity in Plants and Animals
- Genetic diversity and population structure
- Cancer-related gene regulation
- Parasites and Host Interactions
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Animal Nutrition and Physiology
- Marine Bivalve and Aquaculture Studies
- Prenatal Screening and Diagnostics
- Antimicrobial Peptides and Activities
- Vector-Borne Animal Diseases
- Toxin Mechanisms and Immunotoxins
- Reproductive biology and impacts on aquatic species
Commonwealth Scientific and Industrial Research Organisation
2005-2022
Agriculture and Food
2020-2022
The University of Queensland
1997-2020
Animal, Food and Health Sciences
2014
QIMR Berghofer Medical Research Institute
1997-2003
Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form wool represent distinct class animals that have specialized digestive organ, rumen, carries out initial digestion plant material. We developed analyzed high-quality reference sheep genome transcriptomes from 40 different tissues. identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. also involved lipid metabolism had been amplified and/or altered tissue expression...
Human cytomegalovirus (HCMV) can establish both nonproductive (latent) and productive (lytic) infections. Many of the proteins expressed during these phases infection could be expected to targets immune response; however, much our understanding CD8(+)-T-cell response HCMV is mainly based on pp65 antigen. Very little known about T-cell control over other antigens different stages virus infection; this imbalance in undermines importance several aspects disease pathogenesis. In present study,...
Abstract Background Spatiotemporal changes in the chromatin accessibility landscape are essential to cell differentiation, development, health, and disease. The quest of identifying regulatory elements open regions across different tissues developmental stages is led by large international collaborative efforts mostly focusing on model organisms, such as ENCODE. Recently, Functional Annotation Animal Genomes (FAANG) has been established unravel non-model including cattle. Now, we can...
The southern cattle tick, Rhipicephalus (Boophilus) microplus (Canestrini) (Acari: Ixodidae), is a major vector of tick fever organisms affecting in many parts the world, including Australia, Africa, and South America. Control through acaricide use an important approach disease management. Resistance has emerged to acaricides currently previously used, cyclodienes. Although cyclodiene resistance mechanisms have been characterized insect species, this report first identify mutations...
To characterize the role of a range oxidant, antioxidant and mucous-related genes in primary response to gastrointestinal nematodes, groups genetically resistant sheep were challenged with either Haemonchus contortus or Trichostrongylus colubriformis necropsied for retrieval tissue at days 0, 3, 7, 14 21. determine if was localized site parasite infection, four different gut tissues sampled: abomasum, proximal distal jejunum ileum. Basal expression patterns all candidate determined using day...
Experiments that aim to identify genes of importance in sheep are currently inhibited by a paucity genomic resources. One approach, therefore, is exploit the wealth data and associated capabilities becoming available for bovine genome. Cross-species application microarrays comparative sequencing single nucleotide polymorphisms two possibilities; however, both dependant on level sequence similarity between species. This study used 120 gene orthologues consisting over 60 kb aligned estimate...
SUMMARY Two antigens from Babesia bovis , 12D3 and 11C5, were expressed purified as recombinant proteins in Escherichia coli used to vaccinate groups of six ‐susceptible cattle. These subsequently challenged with a highly virulent strain B. . All cattle showed symptoms disease most required treatment. Cattle vaccination receiving either or 11C5 combination both, reduced parasitaemia by approximately fourfold number individual animals appeared control the parasite infection. Control parasites...
The ghrelin axis is involved in the regulation of metabolism, energy balance, and immune, cardiovascular reproductive systems. manipulation this has potential for improving economically valuable traits production animals, polymorphisms (GHRL) receptor (GHSR) genes have been associated with growth carcass traits. Here we investigate structure expression gene sheep, Ovis aries. We identify two mRNA isoforms, which designated Δex2 preproghrelin Δex2,3 preproghrelin. Expression likely to be...
Muscle development and remodelling, mitochondrial physiology inflammation are thought to be inter-related have implications for metabolism in both health disease. However, our understanding of their molecular control is incomplete.In this study we confirmed that the ring finger 14 protein (RNF14), a poorly understood transcriptional regulator, influences expression immune-related genes. The prediction was based on combination network connectivity differential cattle (a non-model organism)...
Abstract Background Despite sexual development being ubiquitous to vertebrates, the molecular mechanisms underpinning this fundamental transition remain largely undocumented in many organisms. We designed a time course experiment that successfully sampled period when Atlantic salmon commence their trajectory towards maturation. Results Through deep RNA sequencing, we discovered key genes and pathways associated with maturation pituitary-ovarian axis. Analyzing DNA methylomes revealed bias...
Abstract Despite sexual development being ubiquitous to vertebrates, the epigenetic mechanisms controlling this fundamental transition remain largely undocumented in many organisms. Through whole-methylome, whole-transcriptome and chromatin landscape sequencing, we discovered global control as well specific regulators of maturation Atlantic salmon. This large integrated study was based on an experimental time course that successfully sampled period when salmon commence their trajectory...
Background: Despite sexual development being ubiquitous to vertebrates, the epigenetic mechanisms controlling this fundamental transition remain largely undocumented in many organisms. Our previous own work showed that despite DNA methylations played a key role upregulating defined set of genes during maturation process, methylation alone does not control genome-wide patterns gene expression. This prompted us characterise epigenomic features onset at chromatin level. Results: We performed...